The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The post‐natal heart contains a myocardial stem cell population
Abstract
The recent identification of stem cell pools in a variety of unexpected tissue sources has raised the possibility that a pluripotent stem cell population may reside in the myocardium and contribute to the post‐natal growth of this tissue. Here, we demonstrate that the post‐natal myocardium contains a resident verapamil‐sensitive side population (SP), with stem cell‐like activity. When growth of the post‐natal heart was attenuated through over‐expression of a dominant negative cardiac transcription factor (MEF2C), the resident SP cell population was subject to activation, followed by a consequent depletion. In addition, cardiac SP cells are capable of fusion with other cell types, but do not adopt the corresponding gene expression profile. These observations suggest that a responsive stem cell pool resides in the adult myocardium, and may influence adaptation of the post‐natal heart.
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Citations
Cites
Changing potency by spontaneous fusion
Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G. (2002) · Nature · doi:10.1038/nature729 · Cited by 1,494
MyoD is required for myogenic stem cell function in adult skeletal muscle
Megeney, L. A., Kablar, B., Garrett, K., Anderson, J. E., & Rudnicki, M. A. (1996) · Genes & Development · doi:10.1101/gad.10.10.1173 · Cited by 724
Self-citation
Cited by
A side order of stem cells: the SP phenotype
Challen, G. A., & Little, M. H. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0116 · Cited by 475
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451
Aging and disease as modifiers of efficacy of cell therapy
Dimmeler, S., & Leri, A. (2008) · Circulation Research · doi:10.1161/circresaha.108.175943 · Cited by 379
Metadata
- Authors
- Hierlihy, A. M., Seale, P., Lobe, C. G., Rudnicki, M. A., & Megeney, L. A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-10-03
- Volume
- 530
- Issue
- 1-3
- Pages
- 239-243
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2132689936
- Cited by
- 450
- References
- 2
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hierlihy, A. M., Seale, P., Lobe, C. G., Rudnicki, M. A., & Megeney, L. A. (2002). The post‐natal heart contains a myocardial stem cell population. FEBS Letters. https://doi.org/10.1016/s0014-5793(02)03477-4
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