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ATP synthesis driven by proton transport in F1F0‐ATP synthase
Open accessAbstract
Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms.
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Cited by
Functional behaviour from controlled self-assembly: challenges and prospects
Ward, M. D., & Raithby, P. R. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35123d · Cited by 444
Proton-powered subunit rotation in single membrane-bound F0F1-ATP synthase
Diez, M., Zimmermann, B., Börsch, M., König, M., Schweinberger, E., Steigmiller, S., Reuter, R., Felekyan, S., Kudryavtsev, V., Seidel, C. A. M., et al. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb718 · Cited by 391
Cysteine Oxidative Posttranslational Modifications: Emerging Regulation in the Cardiovascular System
Chung, H. S., Wang, S.-B., Venkatraman, V., Murray, C. I., & Van Eyk, J. E. (2013) · Circulation Research · doi:10.1161/circresaha.112.268680 · Cited by 300
Co-evolution of primordial membranes and membrane proteins
Mulkidjanian, A. Y., Galperin, M. Y., & Koonin, E. V. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.01.005 · Cited by 169
Metadata
- Authors
- Weber, J., & Senior, A. E.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-04-18
- Volume
- 545
- Issue
- 1
- Pages
- 61-70
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1969381663
- Cited by
- 260
- References
- 0
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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