The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Cysteine Oxidative Posttranslational Modifications: Emerging Regulation in the Cardiovascular System
Open accessAbstract
In the cardiovascular system, changes in oxidative balance can affect many aspects of cellular physiology through redox-signaling. Depending on the magnitude, fluctuations in the cell’s production of reactive oxygen and nitrogen species can regulate normal metabolic processes, activate protective mechanisms, or be cytotoxic. Reactive oxygen and nitrogen species can have many effects including the posttranslational modification of proteins at critical cysteine thiols. A subset can act as redox-switches, which elicit functional effects in response to changes in oxidative state. Although the general concepts of redox-signaling have been established, the identity and function of many regulatory switches remains unclear. Characterizing the effects of individual modifications is the key to understand how the cell interprets oxidative signals under physiological and pathological conditions. Here, we review the various cysteine oxidative posttranslational modifications and their ability to function as redox-switches that regulate the cell’s response to oxidative stimuli. In addition, we discuss how these modifications have the potential to influence other posttranslational modifications’ signaling pathways though cross-talk. Finally, we review the increasing number of tools being developed to identify and quantify the various cysteine oxidative posttranslational modifications and how this will advance our understanding of redox-regulation.
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Citations
Cites
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Cited by
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519
Alquezar, C., Arya, S., & Kao, A. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.595532 · Cited by 367
Normalization of NAD + Redox Balance as a Therapy for Heart Failure
Lee, C. F., Chavez, J. D., Garcia-Menendez, L., Choi, Y., Roe, N. D., Chiao, Y. A., Edgar, J. S., Goo, Y. A., Goodlett, D. R., Bruce, J. E., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.022495 · Cited by 336
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
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“, 2003), as metal-binding residues (Pace and Weerapana, 2014), and as sites for post-translational modification (Chung et al., 2013).”
Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics
Ding, Y., Ting, J. P., Liu, J., Al-Azzam, S., Pandya, P., & Afshar, S. (2020) · Amino Acids · doi:10.1007/s00726-020-02890-9 · Cited by 200
Metadata
- Authors
- Chung, H. S., Wang, S.-B., Venkatraman, V., Murray, C. I., & Van Eyk, J. E.
- Venue
- Circulation Research
- Published
- 2013-01-18
- Volume
- 112
- Issue
- 2
- Pages
- 382-392
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2113352370
- Cited by
- 300
- References
- 93
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- green
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