Co-evolution of primordial membranes and membrane proteins

Mulkidjanian, Armen Y.; Galperin, Michael Y.; Koonin, Eugene V.

doi:10.1016/j.tibs.2009.01.005

Cited by 169Origins and Evolution of LifeATP Synthase and ATPases ResearchLipid Membrane Structure and Behavior

Co-evolution of primordial membranes and membrane proteins

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Mulkidjanian, Armen Y., Galperin, Michael Y., Koonin, Eugene V.·2009·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2009.01.005PMC PMC2752816

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Abstract

Studies of the past several decades have provided major insights into the structural organization of biological membranes and mechanisms of many membrane molecular machines. However, the origin(s) of the membrane(s) and membrane proteins remains enigmatic. We discuss different concepts of the origin and early evolution of membranes with a focus on the evolution of the (im)permeability to charged molecules such as proteins, nucleic acids and small ions. Reconstruction of the evolution of F-type and A/V-type membrane ATPases (ATP synthases), which are either proton- or sodium-dependent, might help us to understand not only the origin of membrane bioenergetics but also of membranes themselves. We argue that evolution of biological membranes occurred as a process of co-evolution of lipid bilayers, membrane proteins and membrane bioenergetics.

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Archaea and Bacteria contain primarily A/V-type and F-type ATP synthase subunits, respectively, and eukaryotes harbor complexes of both types.
“Archaea and Bacteria contain primarily A/V-type and F-type subunits, respectively, and eukaryotes harbor complexes of both types”
From ATP synthase evolution on a cross-braced dated tree of life (2023) · cites this paper as [36]

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[28]Walker JE ATP synthesis by rotary catalysis Angew. Chem 1998 37 2309 2319 29710950
[43]Nicholls DG Ferguson SJ Bioenergetics 2002 3 Academic Press

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Authors: Mulkidjanian, A. Y., Galperin, M. Y., & Koonin, E. V.
Affiliations: Osnabrück University (DE)
National Institutes of Health (US)
Corresponding author: Mulkidjanian, Armen Y.
Koonin, Eugene V.
ORCID: Mulkidjanian, Armen Y.
Galperin, Michael Y.
Koonin, Eugene V.
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2009-04
Volume: 34
Issue: 4
Pages: 206-215
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2009.01.005
PMC: PMC2752816
OpenAlex: W2153085358
Cited by: 169
References: 105
Citations by year: 2026: 6 · 2025: 7 · 2024: 14 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 12
FWCI: 0.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
U.S. National Library of Medicine (Z01LM000073)
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords: membrane protein evolution, lipid bilayers, membrane permeability, membrane ATPase, F-type ATP synthase, membrane bioenergetics, coevolution
MeSH terms: Adenosine Triphosphatases, Cell Membrane, Biological Evolution, Membrane Proteins, Evolution, Molecular

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