The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
PI3K is a key molecule in the Nrf2‐mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells
Open accessAbstract
Oxidative stress and ferrous metabolism are important in the pathogenesis in Parkinson's disease. In dopaminergic neurons, several stress proteins are upregulated under oxidative stress. To clarify this mechanism, we investigated hemin‐related signal transduction and the induction of oxidative stress‐related proteins in SH‐SY5Y cells. We identified phosphatidylinositol 3‐kinase (PI3K) and Nrf2 as important molecules in the induction of heme oxygenase‐1, thioredoxin, and peroxiredoxin‐I. PI3K‐related signal controlled Nrf2 activation, and consequently, PI3K inhibitors blocked the nuclear translocation of Nrf2 and induction of stress proteins. These observations suggest that PI3K and Nrf2 are key molecules in maintaining suitable conditions under oxidative stress and ferrous metabolism.
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Cited by
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
Nguyen, T., Nioi, P., & Pickett, C. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r900010200 · Cited by 2,655
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
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Nrf2–Keap1 defines a physiologically important stress response mechanism
Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725
Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation
Kobayashi, M., & Yamamoto, M. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.385 · Cited by 1,076
Oxidative stress response and Nrf2 signaling in aging
Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804
Metadata
- Authors
- Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada-Isoe, K., & Nakashima, K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-05-27
- Volume
- 546
- Issue
- 2-3
- Pages
- 181-184
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2065190343
- Cited by
- 326
- References
- 33
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada-Isoe, K., & Nakashima, K. (2003). PI3K is a key molecule in the Nrf2‐mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Letters. https://doi.org/10.1016/s0014-5793(03)00517-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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