Oxidative stress response and Nrf2 signaling in aging
Open accessAbstract
Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins, also decline. Importantly, the adaptive response to oxidative stress declines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels, including transcription, posttranslation, and interactions with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Experimental amplification of Nrf2-regulated antioxidant genes increases resistance to oxidative stress in some aged model systems but not others.
“experimental amplification of Nrf2-regulated antioxidant genes has been found to increase resistance to oxidative stress in some aged model systems but not others [207]”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [207]
Nrf2 signaling decreases with age in a variety of model organisms including flies, mice, non-human primates, and humans.
“Nrf2 signaling has been found to decrease with age [207] in a variety of model organisms including flies [208], mice [209], non-human primates [210,211], and humans [207,212,213,214].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [207]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
5 retracted
Niture, S. K., Jain, A. K., & Jaiswal, A. K. (2009) · Journal of Cell Science · doi:10.1242/jcs.058537 · Cited by 192 · see citing works
RetractedPhosphorylation of Tyrosine 568 Controls Nuclear Export of Nrf2
Jain, A. K., & Jaiswal, A. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511198200 · Cited by 171 · see citing works
RetractedDavies, K. J. A., & Shringarpure, R. (2006) · Neurology · doi:10.1212/01.wnl.0000192308.43151.63 · Cited by 80 · see citing works
RetractedRetracted: MiR‐449c targets c‐Myc and inhibits NSCLC cell progression
Miao, L., Huang, S., Sun, Z., Gao, Z., Zhang, R., Liu, Y., & Wang, J. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.03.006 · Cited by 49 · see citing works
RetractedThe Tumor-Suppressive MicroRNA-135b Targets c-Myc in Osteoscarcoma
Liu, Z., Zhang, G., Li, J., Liu, J., & Lv, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102621 · Cited by 43 · see citing works
RetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · see citing works
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works
Hayes, J. D., & Pulford, D. J. (1995) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239509083491 · Cited by 3,471 · see citing works
Targeting the KEAP1-NRF2 system to prevent kidney disease progression
Nezu, M., Suzuki, N., & Yamamoto, M. (2017) · American Journal of Nephrology · doi:10.1159/000475890 · Cited by 3,447 · see citing works
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336 · see citing works
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,011 · see citing works
Mitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010 · see citing works
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277 · see citing works
Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works
Lu, S. C.-L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.008 · Cited by 2,192 · see citing works
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150 · see citing works
Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904 · see citing works
Reinitiation involving upstream ORFs regulates <i>ATF4</i> mRNA translation in mammalian cells
Vattem, K. M., & Wek, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400541101 · Cited by 1,696 · see citing works
Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607 · see citing works
Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118976 · Cited by 1,472 · see citing works
Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464 · see citing works
Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,460 · see citing works
Nrf2 signaling in coordinated activation of antioxidant gene expression
Jaiswal, A. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.074 · Cited by 1,254 · see citing works
(2002) · PubMed · Cited by 1,190 · see citing works
Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102 · see citing works
Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034 · see citing works
Neurodegenerative diseases and oxidative stress
Emerit, J., Edeas, M. A., & Bricaire, F. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2003.11.004 · Cited by 1,031 · see citing works
The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation
Bryan, H. K., Olayanju, A., Goldring, C. E., & Park, B. K. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.016 · Cited by 1,026 · see citing works
Yao, T., Oh, S. P., Fuchs, M., Zhou, N.-D., Ch'ng, L.-E., Newsome, D., Bronson, R. T., Li, E., Livingston, D. M., & Eckner, R. (1998) · Cell · doi:10.1016/s0092-8674(00)81165-4 · Cited by 1,015 · see citing works
Niture, S. K., Khatri, R., & Jaiswal, A. K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.008 · Cited by 873 · see citing works
Lau, A., Wang, X.-J., Zhao, F. L., Villeneuve, N. F., Wu, T., Jiang, T., Sun, Z., White, E., & Zhang, D. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00248-10 · Cited by 851 · see citing works
Stress-activated cap’n’collar transcription factors in aging and human disease
Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · see citing works
Suh, J. H., Shenvi, S. V., Dixon, B. M., Liu, H., Jaiswal, A. K., Liu, R.-M., & Hagen, T. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400282101 · Cited by 774 · see citing works
Beal, M. F. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00780-3 · Cited by 763 · see citing works
Enomoto, A. (2001) · Toxicological Sciences · doi:10.1093/toxsci/59.1.169 · Cited by 728 · see citing works
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
Arias, J., Alberts, A. S., Brindle, P. K., Claret, F. X., Smeal, T., Karin, M., Feramisco, J. R., & Montminy, M. (1994) · Nature · doi:10.1038/370226a0 · Cited by 726 · see citing works
Forman, H. J., Davies, K. J. A., & Ursini, F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.045 · Cited by 707 · see citing works
Functional antioxidant responsive elements
Wasserman, W. W., & Fahl, W. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5361 · Cited by 705 · see citing works
Oyake, T., Itoh, K., Motohashi, H., Hayashi, N., Hoshino, H., Nishizawa, M., Yamamoto, M. P., & Igarashi, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6083 · Cited by 656 · see citing works
Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.029 · Cited by 638 · see citing works
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf516 · Cited by 637 · see citing works
Nguyen, T., Sherratt, P. J., Huang, H.-C., Yang, C. S., & Pickett, C. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207293200 · Cited by 615 · see citing works
Is the oxidative stress theory of aging dead?
Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Ando, J., Iwadate, M., Yamamoto, M. P., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201102031 · Cited by 602 · see citing works
Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2
Wild, A. C., Moinova, H., & Mulcahy, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33627 · Cited by 595 · see citing works
Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581 · see citing works
Disruption of <i>Nrf2</i> enhances susceptibility to severe airway inflammation and asthma in mice
Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050538 · Cited by 580 · see citing works
Oxidative stress and vascular inflammation in aging
Assar, M. E., Angulo, J., & Rodríguez‐Mañas, L. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.003 · Cited by 576 · see citing works
Nrf2 is essential for protection against acute pulmonary injury in mice
Chan, K., & Kan, Y. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12731 · Cited by 574 · see citing works
Radjendirane, V., & Jaiswal, A. K. (1998) · Oncogene · doi:10.1038/sj.onc.1202237 · Cited by 566 · see citing works
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism
Bota, D. A., & Davies, K. J. A. (2002) · Nature Cell Biology · doi:10.1038/ncb836 · Cited by 557 · see citing works
Self-citationKang, M.-I., Kobayashi, A., Wakabayashi, N., Kim, S.-G., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308347100 · Cited by 536 · see citing works
Autophagy and aging: keeping that old broom working
Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works
Bloom, D. A., & Jaiswal, A. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307633200 · Cited by 523 · see citing works
Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans
Titus, S., Li, F., Stobezki, R., Akula, K., Ünsal, E., Jeong, K., Dickler, M. N., Robson, M. E., MOY, F. H., Goswami, S., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004925 · Cited by 523 · see citing works
Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., & Yamamoto, M. P. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00469.x · Cited by 521 · see citing works
Oxidative stress and protein aggregation during biological aging
Squier, T. C. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00139-5 · Cited by 511 · see citing works
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl
Somasundaram, K., Zhang, H., Zeng, Y., Houvras, Y. J., Peng, Y., Zhang, H., Wu, G. S., Licht, J. D., Weber, B. L., & El‐Deiry, W. S. (1997) · Nature · doi:10.1038/38291 · Cited by 509 · see citing works
Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
Zheng, H., Whitman, S. A., Wu, W., Wondrak, G. T., Wong, P. K., Fang, D., & Zhang, D. D. (2011) · Diabetes · doi:10.2337/db11-0807 · Cited by 507 · see citing works
Jain, A. K., & Jaiswal, A. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611336200 · Cited by 484 · see citing works
Friling, R. S., Bensimon, A., Tichauer, Y., & Daniel, V. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6258 · Cited by 475 · see citing works
The redox stress hypothesis of aging
Sohal, R. S., & Orr, W. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.445 · Cited by 473 · see citing works
Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein
He, C. H., Gong, P., Hu, B., Stewart, D., Choi, M. E., Choi, A. M. K., & Alam, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101198200 · Cited by 473 · see citing works
Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
Tong, K. I., Kobayashi, A., Katsuoka, F., & Yamamoto, M. (2006) · Biological Chemistry · doi:10.1515/bc.2006.164 · Cited by 473 · see citing works
The effects of stress and aging on glutathione metabolism
Maher, P. A. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.02.005 · Cited by 426 · see citing works
Dhakshinamoorthy, S., Jain, A. K., Bloom, D. A., & Jaiswal, A. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500166200 · Cited by 414 · see citing works
Sun, Z., Chin, Y. E., & Zhang, D. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01639-08 · Cited by 413 · see citing works
Lipid peroxidation, antioxidant protection and aging
Rikans, L. E., & Hornbrook, K. R. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(97)00067-7 · Cited by 413 · see citing works
Telomere dysfunction and tumour suppression: the senescence connection
Deng, Y., Chan, S. S., & Chang, S. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2393 · Cited by 411 · see citing works
Zhu, H., Itoh, K., Yamamoto, M. P., Zweier, J. L., & Li, Y. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.058 · Cited by 394 · see citing works
Regulation of SUMOylation by Reversible Oxidation of SUMO Conjugating Enzymes
Bossis, G., & Melchior, F. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.019 · Cited by 390 · see citing works
Antioxidant enzyme activities and malondialdehyde levels related to aging
İnal, M., Kanbak, G., & Sunal, E. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00422-8 · Cited by 383 · see citing works
BRCA1 regulates p53-dependent gene expression
Ouchi, T., Monteiro, Á. N. A., August, A., Aaronson, S. A., & Hanafusa, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2302 · Cited by 375 · see citing works
Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
Hochmuth, C. E., Biteau, B., Bohmann, D., & Jasper, H. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.006 · Cited by 364 · see citing works
Biological variability of superoxide dismutase, glutathione peroxidase, and catalase in blood
Guemouri, L., Artur, Y., Herbeth, B., Jeandel, C., Cuny, G., & Siest, G. (1991) · Clinical Chemistry · doi:10.1093/clinchem/37.11.1932 · Cited by 363 · see citing works
microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age
Noren Hooten, N., Abdelmohsen, K., Gorospe, M., Ejiogu, N., Zonderman, A. B., & Evans, M. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010724 · Cited by 357 · see citing works
Li, Y., & Jaiswal, A. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42151-5 · Cited by 353 · see citing works
Inflammation and oxidative stress in vertebrate host–parasite systems
Sorci, G., & Faivre, B. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0151 · Cited by 350 · see citing works
The role of mitochondrial oxidative stress in aging
Sastre, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00184-9 · Cited by 342 · see citing works
Sekhar, R. V., Patel, S. G., Guthikonda, A. P., Reid, M., Balasubramanyam, A., Taffet, G. E., & Jahoor, F. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.003483 · Cited by 336 · see citing works
Junqueira, V. B. C., Barros, S. B. D. M., Chan, S. S., Rodrigues, L., Giavarotti, L., Abud, R. L., & Deucher, G. P. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.003 · Cited by 329 · see citing works
Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada‐Isoe, K., & Nakashima, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00517-9 · Cited by 324 · see citing works
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
Hayes, J. D. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00695-4 · Cited by 323 · see citing works
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
Sitte, N., Huber, M., Grune, T., Ladhoff, A., Doecke, W., Zglinicki, T. V., & Davies, K. J. A. (2000) · The FASEB Journal · doi:10.1096/fj.14.11.1490 · Cited by 318 · see citing works
Alterations of antioxidant enzymes and oxidative stress markers in aging
Kasapoglu, M., & Özben, T. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00198-4 · Cited by 312 · see citing works
Shi, M. M., Kugelman, A., Iwamoto, T., Tian, L., & Forman, H. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47224-9 · Cited by 307 · see citing works
Plasma antioxidants and longevity: a study on healthy centenarians
Mecocci, P., Polidori, M. C., Troiano, L., Cherubini, A., Cecchetti, R., Pini, G., Straatman, M., Monti, D., Stahl, W., Sies, H., et al. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00246-x · Cited by 306 · see citing works
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
Khor, T. O., Huang, M.-T., Prawan, A., Liu, Y., Hao, X., Yu, S., Cheung, W. K. L., Chan, J. Y., Reddy, B. S., Yang, C. S., et al. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0028 · Cited by 306 · see citing works
miR-200a Regulates Nrf2 Activation by Targeting Keap1 mRNA in Breast Cancer Cells
Eades, G. L., Yang, M., Yao, Y., Zhang, Y., & Zhou, Q. Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275495 · Cited by 305 · see citing works
Keum, Y., Yu, S., Chang, P. P.-J., Yuan, X., Kim, J. H., Xu, C., Han, J., Agarwal, A., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3513 · Cited by 305 · see citing works
Role of redox-regulated transcription factors in inflammation, aging and age-related diseases
Lavrovsky, Y. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00118-2 · Cited by 305 · see citing works
Antioxidative enzyme activities in human erythrocytes
Andersen, H. R., Nielsen, J. B., Nielsen, F., & Grandjean, P. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.4.562 · Cited by 301 · see citing works
Free radical adducts induce alterations in DNAcytosine methylation.
Weitzman, S. A., Turk, P. W., Milkowski, D. H., & Kozlowski, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1261 · Cited by 299 · see citing works
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K., & Yamamoto, M. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9176 · Cited by 297 · see citing works
Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary
Lim, J., & Luderer, U. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.088583 · Cited by 290 · see citing works
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
Gorrini, C., Baniasadi, P. S., Harris, I. S., Silvester, J., Inoue, S., Snow, B., Joshi, P. A., Wakeham, A., Molyneux, S. D., Martin, B., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121337 · Cited by 289 · see citing works
Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
Gan, L., & Johnson, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.011 · Cited by 288 · see citing works
Age-associated increase in aneuploidy and changes in gene expression in mouse eggs
Pan, H., Ma, P., Zhu, W., & Schultz, R. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.01.048 · Cited by 283 · see citing works
Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling
Naidoo, N. N., Ferber, M., Master, M., Zhu, Y., & Pack, A. I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5685-07.2008 · Cited by 282 · see citing works
ER and aging—Protein folding and the ER stress response
Naidoo, N. N. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.001 · Cited by 280 · see citing works
Pickering, A. M., Linder, R. A., Zhang, H., Forman, H. J., & Davies, K. J. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277145 · Cited by 280 · see citing works
MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
Yang, M., Yao, Y., Eades, G. L., Zhang, Y., & Zhou, Q. Y. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1604-1 · Cited by 280 · see citing works
Age-related changes in glutathione and glutathione-related enzymes in rat brain
Zhu, Y., Carvey, P. M., & Ling, Z. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.063 · Cited by 279 · see citing works
Ungvari, Z. I., Bailey‐Downs, L. C., Sosnowska, D., Gautam, T., Koncz, P., Losonczy, G., Ballabh, P., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01134.2010 · Cited by 274 · see citing works
Kang, K. W., Lee, S. J., Park, J. W., & Kim, S. G. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.1001 · Cited by 272 · see citing works
Aggarwal, B. B., Deb, L., & Prasad, S. (2014) · Molecules · doi:10.3390/molecules20010185 · Cited by 270 · see citing works
Xu, C., Yuan, X., Pan, Z., Shen, G., Kim, J. H., Yu, S., Khor, T. O., Li, W., Ma, J., & Kong, A. T. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0497 · Cited by 265 · see citing works
Glutathione Metabolism during Aging and in Alzheimer Disease
LIU, H., Wang, H., Shenvi, S. V., Hagen, T. M., & LIU, R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.059 · Cited by 258 · see citing works
Kim, Y.-J., Ahn, J., Liang, P., Ip, C. C. Y., Zhang, Y., & Park, Y.-M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2401 · Cited by 256 · see citing works
van Huizen, R., Martindale, J. L., Gorospe, M., & Holbrook, N. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212074200 · Cited by 256 · see citing works
Zipper, L. M. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg083 · Cited by 252 · see citing works
Moinova, H., & Mulcahy, R. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1109 · Cited by 245 · see citing works
BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells
Wang, Q., Zhang, H., Kajino, K., & Greene, M. I. (1998) · Oncogene · doi:10.1038/sj.onc.1202403 · Cited by 243 · see citing works
p62: a versatile multitasker takes on cancer
Moscat, J., & Díaz-Meco, M. T. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.02.008 · Cited by 239 · see citing works
Protein turnover by the proteasome in aging and disease
Shringarpure, R., & Davies, K. J. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00824-9 · Cited by 236 · see citing works
Markers of oxidant stress that are clinically relevant in aging and age-related disease
Jacob, K. D., Hooten, N. N., Trzeciak, A. R., & Evans, M. K. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.02.008 · Cited by 233 · see citing works
Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress
Bota, D. A., Van Remmen, H., & Davies, K. J. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03638-4 · Cited by 233 · see citing works
Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner
Lau, A., Zheng, Y., Tao, S., Wang, H., Whitman, S. A., White, E., & Zhang, D. D. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01748-12 · Cited by 229 · see citing works
Meakin, P. J., Chowdhry, S., Sharma, R. S., Ashford, F. B., Walsh, S. V., McCrimmon, R. J., Dinkova‐Kostova, A. T., Dillon, J. F., Hayes, J. D., & Ashford, M. L. J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00677-14 · Cited by 229 · see citing works
Ungvari, Z. I., Bailey‐Downs, L. C., Gautam, T., Sosnowska, D., Wang, M., Monticone, R. E., Telljohann, R. S., Pinto, J. T., de Cabo, R., Sonntag, W. E., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr092 · Cited by 228 · see citing works
Deng, X., Rui, W., Zhang, F., & Ding, W. (2013) · Cell Biology and Toxicology · doi:10.1007/s10565-013-9242-5 · Cited by 227 · see citing works
Turk, P. W., Laayoun, A., Smith, S. S., & Weitzman, S. A. (1995) · Carcinogenesis · doi:10.1093/carcin/16.5.1253 · Cited by 226 · see citing works
Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1
Taguchi, K., Maher, J. M., Suzuki, T., Kawatani, Y., Motohashi, H., & Yamamoto, M. P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01591-09 · Cited by 225 · see citing works
Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung
Kelsen, S. G., Duan, X., Ji, R., Pérez, Ó. C., Liu, C., & Merali, S. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0221oc · Cited by 223 · see citing works
CBP/p300 interact with and function as transcriptional coactivators of BRCA1
Pao, G. M., Janknecht, R., Ruffner, H., Hunter, T. R., & Verma, I. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1020 · Cited by 222 · see citing works
BRCA1 Induces Antioxidant Gene Expression and Resistance to Oxidative Stress
Bae, I., Fan, S., Meng, Q., Rih, J. K., Kim, H. J., Kang, H. J., Xu, J., Goldberg, I. D., Jaiswal, A. K., & Rosen, E. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1119 · Cited by 222 · see citing works
Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy
Myeku, N., & Figueiredo‐Pereira, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149252 · Cited by 221 · see citing works
Nrf2: control of sensitivity to carcinogens
Slocum, S. L., & Kensler, T. W. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0675-4 · Cited by 219 · see citing works
Grune, T., Catalgol, B., Licht, A., Ermak, G., Pickering, A. M., Ngo, J. K., & Davies, K. J. A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.015 · Cited by 217 · see citing works
miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells
van Jaarsveld, M. T. M., Helleman, J., Boersma, A. W. M., van Kuijk, P. F., van IJcken, W. F. J., Despierre, E., Vergote, I. B., Mathijssen, R. H. J., Berns, E., Verweij, J., et al. (2012) · Oncogene · doi:10.1038/onc.2012.433 · Cited by 217 · see citing works
Cheng, X., Ku, C.-H., & Siow, R. C. M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.025 · Cited by 217 · see citing works
Higgins, L. G., & Hayes, J. D. (2011) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.567391 · Cited by 217 · see citing works
Bartlett, B. J., Isakson, P., Lewerenz, J., Sanchez, H., Kotzebue, R. W., Cumming, R. C., Harris, G. L., Nezis, I. P., Schubert, D. R., Simonsen, A., et al. (2011) · Autophagy · doi:10.4161/auto.7.6.14943 · Cited by 215 · see citing works
The Free Radical Theory of Aging Revisited: The Cell Signaling Disruption Theory of Aging
Viña, J., Borrás, C., Abdelaziz, K. M., Garcia-Valles, R., & Gómez‐Cabrera, M. C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5111 · Cited by 215 · see citing works
Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver
Ji, L., Dillon, D. A. R., & Wu, E. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.4.r918 · Cited by 215 · see citing works
Sitte, N., Merker, K., von Zglinicki, T., Grune, T., & Davies, K. J. A. (2000) · The FASEB Journal · doi:10.1096/fj.00-0209com · Cited by 213 · see citing works
Low blood glutathione levels in healthy aging adults.
Lang, C. A., Naryshkin, S., Schneider, D. L., Mills, B. J., & Lindeman, R. D. (1992) · PubMed · Cited by 213 · see citing works
Pansarasa, O., Bertorelli, L., Vecchiet, J., Felzani, G., & Marzatico, F. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00108-2 · Cited by 212 · see citing works
Li, N., Muthusamy, S., Liang, R., Sarojini, H., & Wang, E. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.12.004 · Cited by 211 · see citing works
Nrf2 signaling is impaired in the aging RPE given an oxidative insult
Sachdeva, M. M., Cano, M., & Handa, J. T. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2013.10.024 · Cited by 207 · cited 2× · see citing works
“On the other hand, a recent study showed that Keap1 knockout partially restored the induction of NQO-1, whose induction was impaired in the retinal pigment epithelium of middle-aged mice (15 mo), while the induction of HO-1 and GCLM was not recovered [158].”
Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., & Hara, S. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20246 · Cited by 207 · see citing works
Hua, Y., Zhang, Y., Ceylan‐Isik, A. F., Wold, L. E., Nunn, J. M., & Ren, J. T. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0222-8 · Cited by 204 · see citing works
Anantharaju, A., Feller, A., & Chedid, A. (2002) · Gerontology · doi:10.1159/000065506 · Cited by 201 · see citing works
MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis
Singh, B. P., Ronghe, A. M., Chatterjee, A., Bhat, N. K., & Bhat, H. K. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt026 · Cited by 200 · see citing works
Hou, W., Tian, Q., Zheng, J., & Bonkovsky, H. L. (2009) · Hepatology · doi:10.1002/hep.23401 · Cited by 199 · see citing works
Chen, Z.-H., Saito, Y., Yoshida, Y., Sekine, A., Noguchi, N., & Niki, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508556200 · Cited by 197 · see citing works
A genomic screen for activators of the antioxidant response element
Liu, Y., Kern, J. T., Walker, J. R., Johnson, J. A., Schultz, P. G., & Luesch, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700898104 · Cited by 196 · see citing works
The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction
Morgan, T. E., Xie, Z., Goldsmith, S., Yoshida, T., Lanzrein, A.-S., Stone, D., Rozovsky, I., Perry, G., Smith, M. A., & Finch, C. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00334-0 · Cited by 195 · see citing works
Pro-oxidant shift in glutathione redox state during aging
Rebrin, I., & Sohal, R. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.06.001 · Cited by 194 · see citing works
Regulation of Nrf2 Transactivation Domain Activity
Shen, G., Hebbar, V., Nair, S., Xu, C., Li, W., Lin, W., Keum, Y.-S., Han, J., Gallo, M. A., & Kong, A.-N. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401368200 · Cited by 194 · see citing works
Luo, L., Lu, A.-M., Wang, Y., Hong, A., Chen, Y., Hu, J., Li, X., & Qin, Z.-H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.009 · Cited by 192 · see citing works
Igarashi, K., Hoshino, H., Muto, A., Suwabe, N., Nishikawa, S., Nakauchi, H., & Yamamoto, M. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11783 · Cited by 191 · see citing works
Lu, C.-Y., Lee, H.-C., Fahn, H.-J., & Wei, Y.-H. (1999) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(98)00220-6 · Cited by 186 · see citing works
Shih, P., & Yen, G. (2006) · Biogerontology · doi:10.1007/s10522-006-9033-y · Cited by 185 · see citing works
Nadiminty, N., Tummala, R., Lou, W., Zhu, Y., Zhang, J., Chen, X., White, R. D., Kung, H., Evans, C. P., & Gao, A. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.278705 · Cited by 184 · see citing works
Ceballos-Picot, I., Trivier, J.-M., Nicole, A., Sinet, P., & Thévenin, M. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.1.66 · Cited by 181 · see citing works
The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer
Zhang, D. D. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3301 · Cited by 177 · see citing works
Dickinson, D. A., Iles, K. E., Zhang, H., Blank, V., & Forman, H. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0566fje · Cited by 176 · see citing works
Varı́, R., D’Archivio, M., Filesi, C., Carotenuto, S., Scazzocchio, B., Santangelo, C., Giovannini, C., & Masella, R. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.03.008 · Cited by 171 · see citing works
Gounder, S. S., Kannan, S., Devadoss, D., Miller, C. J., Whitehead, K. S., Odelberg, S. J., Firpo, M. A., Paine, R., Hoidal, J. R., Abel, E. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045697 · Cited by 171 · see citing works
Cadmium Induces Nuclear Export of Bach1, a Transcriptional Repressor of Heme Oxygenase-1 Gene
Suzuki, H., Tashiro, S., Sun, J., Doi, H., Satomi, S., & Igarashi, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306764200 · Cited by 170 · see citing works
Role of Bach1 and Nrf2 in up‐regulation of the heme oxygenase‐1 gene by cobalt protoporphyrin
Shan, Y., Lambrecht, R. W., Donohue, S. E., & Bonkovsky, H. L. (2006) · The FASEB Journal · doi:10.1096/fj.06-6346fje · Cited by 167 · see citing works
Nrf2 and Cardiovascular Defense
Howden, R. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/104308 · Cited by 163 · see citing works
Shan, Y., Zheng, J., Lambrecht, R. W., & Bonkovsky, H. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.002 · Cited by 162 · see citing works
Csiszár, A., Gautam, T., Sosnowska, D., Tarantini, S., Banki, E., Tucsek, Z., Tóth, P., Losonczy, G., Koller, Á., Reglődi, D., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00307.2014 · Cited by 161 · see citing works
Regulation of growth arrest in senescence: Telomere damage is not the end of the story
Herbig, U., & Sedivy, J. M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.002 · Cited by 159 · see citing works
Age and sex influence on oxidative damage and functional status in human skeletal muscle.
Fanò, G., Mecocci, P., Vecchiet, J., Belia, S., Fulle, S., Polidori, M. C., Felzani, G., Senin, U., Vecchiet, L., & Beal, M. F. (2001) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1013122805060 · Cited by 158 · see citing works
Sitte, N., Merker, K., von Zglinicki, T., Davies, K. J. A., & Grune, T. (2000) · The FASEB Journal · doi:10.1096/fj.00-0210com · Cited by 157 · see citing works
Deng, C., Sun, Z., Tong, G., Yi, W., Ma, L., Zhao, B., Cheng, L., Zhang, J., Cao, F., & Ding-hua, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058371 · Cited by 156 · see citing works
Zhang, H., Liu, H., Davies, K. J. A., Sioutas, C., Finch, C. E., Morgan, T. E., & Forman, H. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.042 · Cited by 155 · see citing works
Sakai, M., Okuda, A., & Muramatsu, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9456 · Cited by 153 · see citing works
Yamamura, S., Saini, S., Majid, S., Hirata, H., Ueno, K., Deng, G., & Dahiya, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029722 · Cited by 152 · see citing works
Zhao, J., Feng, L., Liu, Y., Jiang, W., Wu, P., Jiang, J., Zhang, Y., & Zhou, X. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.10.002 · Cited by 152 · see citing works
Nguyen, T. H., Rushmore, T. H., & Pickett, C. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36880-1 · Cited by 150 · see citing works
MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression
Kappelmann‐Fenzl, M., Kuphal, S., Meister, G., Vardimon, L., & Bosserhoff, A. (2012) · Oncogene · doi:10.1038/onc.2012.307 · Cited by 149 · see citing works
p 21WAF1 C ontrol of E pithelial C ell C ycle and C ell F ate
Weinberg, W. C., & Denning, M. F. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300603 · Cited by 149 · see citing works
Zhu, M., & Fahl, W. E. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5944 · Cited by 148 · see citing works
Miller, C. J., Gounder, S. S., Kannan, S., Karan, G., Muthusamy, V. R., Firpo, M. A., Symons, J. D., Paine, R., Hoidal, J. R., & Rajasekaran, N. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.007 · Cited by 146 · see citing works
Li, M., Cha, Y., & Surh, Y. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.06.010 · Cited by 144 · see citing works
Soriano, F. X., Léveillé, F., Papadia, S., Higgins, L. G., Varley, J. A., Baxter, P. S., Hayes, J. D., & Hardingham, G. E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05648.x · Cited by 144 · see citing works
Reduced eIF2α phosphorylation and increased proapoptotic proteins in aging
Syed, G. H., & Ramaiah, K. V. A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.156 · Cited by 143 · see citing works
Afonyushkin, T., Oskolkova, O., Philippova, M., Resink, T. J., Erné, P., Binder, B. R., & Bochkov, V. N. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.204354 · Cited by 143 · see citing works
Levy, S., & Forman, H. J. (2010) · IUBMB Life · doi:10.1002/iub.314 · Cited by 142 · see citing works
Landis, G. N., Shen, J., & Tower, J. (2012) · Aging · doi:10.18632/aging.100499 · Cited by 142 · see citing works
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
Sitte, N., Huber, M., Grune, T., et al. (2000) · The FASEB Journal · doi:10.1096/fj.99-0843com · Cited by 142 · see citing works
Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats
Liu, R.-M., & Choi, J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00269-5 · Cited by 140 · see citing works
Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade
Kwon, J., Han, E., Bui, C., Shin, W., Lee, J. H., Lee, S., Choi, Y., Lee, A., Lee, K., Park, C., et al. (2012) · EMBO Reports · doi:10.1038/embor.2011.246 · Cited by 139 · see citing works
Ngo, J. K., Pomatto, L. C. D., & Davies, K. J. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.015 · Cited by 138 · see citing works
Sullivan, M., & Lewandowski, P. A. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-104 · Cited by 138 · see citing works
Kaspar, J. W., & Jaiswal, A. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040022 · Cited by 136 · see citing works
Lima, C. F., Pereira‐Wilson, C., & Rattan, S. I. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000221 · Cited by 136 · see citing works
Yang, F., Chu, X., Yin, M., Liu, X., Yuan, H., Niu, Y., & Fu, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.005 · Cited by 136 · see citing works
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals
Conrad, M., Schneider, M., Seiler, A., & Bornkamm, G. W. (2007) · Biological Chemistry · doi:10.1515/bc.2007.130 · Cited by 136 · see citing works
Butterfield, D. A., Howard, B. J., & LaFontaine, M. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373048 · Cited by 134 · see citing works
The aging kidney: increased susceptibility to nephrotoxicity
Wang, X., Bonventre, J., & Parrish, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150915358 · Cited by 132 · see citing works
Zhen, Y., Liu, Z., Yang, H., Yu, X., Wu, Q., Hua, S., Long, X., Jiang, Q., Song, Y., Cheng, C., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.376 · Cited by 131 · see citing works
Weir, C., & Robaire, B. (2007) · Journal of Andrology · doi:10.2164/jandrol.106.001362 · Cited by 131 · see citing works
Flagged first, then by citations
6 of the 429 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy
Forman, H. J., & Zhang, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00233-1 · Cited by 2,900 · see citing works
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works
An aged immune system drives senescence and ageing of solid organs
Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature · doi:10.1038/s41586-021-03547-7 · Cited by 972 · see citing works
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
Manchester, L. C., Coto‐Montes, A. M., Boga, J. A., Andersen, L. P. H., Zhou, Z., Galano, A., Vriend, J. P., Tan, D. X., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12267 · Cited by 954 · see citing works
Buendía, I., Michalska, P., Navarro, E., Gameiro‐Ros, I., Egea, J., & Leon, R. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 683 · see citing works
Gureev, A. P., Shaforostova, E. A., & Popov, V. N. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00435 · Cited by 652 · see citing works
Sivandzade, F., Prasad, S., Bhalerao, A., & Cucullo, L. (2019) · Redox Biology · doi:10.1016/j.redox.2018.11.017 · Cited by 639 · see citing works
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
Zuo, L., Prather, E. R., Stetskiv, M., Garrison, D. E., Meade, J. R., Peace, T. I., & Zhou, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184472 · Cited by 545 · see citing works
Modulating NRF2 in Disease: Timing Is Everything
Dodson, M. B., de la Vega, M. R., Cholanians, A. B., Schmidlin, C. J., Chapman, E., & Zhang, D. D. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021856 · Cited by 540 · see citing works
A novel and compact review on the role of oxidative stress in female reproduction
Lu, J., Wang, Z., Cao, J., Chen, Y., & Dong, Y. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0391-5 · Cited by 482 · see citing works
Inflammation in Glaucoma: From the back to the front of the eye, and beyond
Baudouin, C., Kolko, M., Parsadaniantz, S. M., & Messmer, E. S. B. M. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100916 · Cited by 470 · see citing works
Redox regulation by NRF2 in aging and disease
Schmidlin, C. J., Dodson, M. B., Madhavan, L., & Zhang, D. D. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.016 · Cited by 441 · see citing works
The metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works
Davies, K. J. A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.007 · Cited by 330 · see citing works
Oxidative stress in the eye and its role in the pathophysiology of ocular diseases
Böhm, E. W., Buonfiglio, F., Voigt, A. M., Bachmann, P., Safi, T., Pfeiffer, N., & Gericke, A. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102967 · Cited by 324 · see citing works
Skeletal muscle aging: influence of oxidative stress and physical exercise
Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285 · see citing works
Frailty and sarcopenia - newly emerging and high impact complications of diabetes
Sinclair, A. J., Abdelhafiz, A. H., & Rodríguez-Mañas, L. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.05.003 · Cited by 276 · see citing works
Xu, J., Chu, T., Yu, T., Li, N., Wang, C., Li, C., Zhang, Y., Meng, H., & Nie, G. (2022) · ACS Nano · doi:10.1021/acsnano.2c05558 · Cited by 267 · see citing works
Oxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 309 · see citing works
Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke
Zhang, R., Xu, M., Wang, Y., Xie, F., Zhang, G., & Qin, X. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0111-0 · Cited by 243 · see citing works
Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging
Lapenna, D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102066 · Cited by 239 · see citing works
Netto, M. B., de Oliveira, A. N., Goldim, M. P. D. S., Mathias, K., Fileti, M. E., da Rosa, N., Laurentino, A. O. M., de Farias, B. X., Costa, A. B., Rezin, G. T., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.016 · Cited by 228 · see citing works
Protective Factors and the Pathogenesis of Complications in Diabetes
Yu, M. G., Gordin, D., Fu, J., Park, K., Li, Q., & King, G. L. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad030 · Cited by 239 · see citing works
The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging
Yang, L., Chen, Y., Liu, Y., Xing, Y., Miao, C., Zhao, Y., Chang, X., & Zhang, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.617843 · Cited by 231 · see citing works
Adaptive homeostasis and the free radical theory of ageing
Pomatto, L. C. D., & Davies, K. J. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.016 · Cited by 224 · see citing works
Aging - Oxidative stress, antioxidants and computational modeling
Warraich, U.-E.-A., Hussain, F., & Kayani, H. U. R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04107 · Cited by 212 · see citing works
Shengchen, W., Jing, L., Yujie, Y., Yue, W., & Xu, S. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125962 · Cited by 208 · see citing works
Nrf2 and oxidative stress in liver ischemia/reperfusion injury
Bardallo, R. G., Rosello, A. P., Sánchez-Nuño, S., Alva, N., Roselló‐Catafau, J., & Carbonell, T. (2021) · FEBS Journal · doi:10.1111/febs.16336 · Cited by 208 · see citing works
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases
George, M., Tharakan, M., Culberson, J. W., Reddy, A. P., & Reddy, P. H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101756 · Cited by 212 · see citing works
Saha, S., Buttari, B., Profumo, E., Tucci, P., & Saso, L. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.787258 · Cited by 205 · see citing works
Fetoni, A. R., Paciello, F., Rolesi, R., Paludetti, G., & Troiani, D. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.02.022 · Cited by 201 · see citing works
Liu, Q., Jin, Z., Xu, Z., Yang, H., Li, L., Li, G., Li, F., Gu, S.-L., Zong, S., Zhou, J., et al. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-00977-1 · Cited by 196 · see citing works
Chen, L., Yang, R., Qiao, W., Zhang, W. Y., Chen, J., Mao, L., Goltzman, D., & Miao, D. (2019) · Aging Cell · doi:10.1111/acel.12951 · Cited by 194 · see citing works
RetractedKageyama, H., & Waditee‐Sirisattha, R. (2019) · Marine Drugs · doi:10.3390/md17040222 · Cited by 194 · see citing works
Chen, B., Sun, Y., Zhang, J., Zhu, Q., Yang, Y., Niu, X., Deng, Z., Li, Q., & Wang, Y. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1253-6 · Cited by 189 · see citing works
3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases
Bandookwala, M., & Sengupta, P. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1713776 · Cited by 187 · see citing works
Angulo, J., Assar, M. E., & Rodríguez‐Mañas, L. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.06.001 · Cited by 185 · see citing works
Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target
Bellezza, I. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01280 · Cited by 174 · see citing works
Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
Butawan, M. B., Benjamin, R. L., & Bloomer, R. J. (2017) · Nutrients · doi:10.3390/nu9030290 · Cited by 184 · see citing works
Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?
Liddell, J. R. (2017) · Antioxidants · doi:10.3390/antiox6030065 · Cited by 167 · see citing works
Nitti, M., Piras, S., Brondolo, L., Marinari, U. M., Pronzato, M. A., & Furfaro, A. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082260 · Cited by 161 · see citing works
Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins
Palmeira, C. M., Teodoro, J. S., Amorim, J. A., Steegborn, C., Sinclair, D. A., & Rolo, A. P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.07.017 · Cited by 159 · see citing works
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
Ji, S., Xiong, M., Chen, H., Liu, Y., Zhou, L., Hong, Y., Wang, M., Wang, C., Fu, X., & Sun, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01343-5 · Cited by 166 · see citing works
Sulforaphane - role in aging and neurodegeneration
Santín-Márquez, R., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Chondrogianni, N., & Königsberg, M. (2019) · GeroScience · doi:10.1007/s11357-019-00061-7 · Cited by 153 · see citing works
Bota, D. A., & Davies, K. J. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.031 · Cited by 148 · see citing works
Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease
Branca, C., Ferreira, E., Nguyen, T.-V., Doyle, K., Caccamo, A., & Oddo, S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx361 · Cited by 139 · see citing works
Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway
Liu, X., Lin, X., Zhang, S., Guo, C., Li, J., Mi, Y., & Zhang, C. (2018) · Aging · doi:10.18632/aging.101526 · Cited by 147 · see citing works
Zhou, L., Zhang, H., Davies, K. J. A., & Forman, H. J. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.014 · Cited by 145 · see citing works
Redox Regulation of Homeostasis and Proteostasis in Peroxisomes
Walker, C. L., Pomatto, L. C. D., Tripathi, D. N., & Davies, K. J. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2016 · Cited by 145 · see citing works
Long Noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy
Radhakrishnan, R., & Kowluru, R. A. (2020) · Diabetes · doi:10.2337/db20-0375 · Cited by 135 · see citing works
The potential role of necroptosis in inflammaging and aging
Royce, G. H., Brown‐Borg, H. M., & Deepa, S. S. (2019) · GeroScience · doi:10.1007/s11357-019-00131-w · Cited by 135 · see citing works
The Influence of Lifestyle and Treatment on Oxidative Stress and Inflammation in Diabetes
Wronka, M., Krzemińska, J., Młynarska, E., Rysz, J., & Franczyk, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415743 · Cited by 135 · see citing works
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury
Jadeja, R. N., Upadhyay, K. K., Devkar, R., & Khurana, S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3453926 · Cited by 127 · see citing works
Bousquet, J., Antó, J. M., Czarlewski, W., Haahtela, T., Fonseca, S. C., Iaccarino, G., Blain, H., Vidal, A., Sheikh, A., Akdiş, C. A., et al. (2020) · Allergy · doi:10.1111/all.14549 · Cited by 122 · see citing works
Guo, Y., Xue, L., Tang, W., Xiong, J., Chen, D., Dai, Y., Wu, C., Wei, S., Dai, J. Y., Wu, M., et al. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae020 · Cited by 124 · see citing works
Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
Davinelli, S., Maes, M., Corbi, G., Zarrelli, A., Willcox, D. C., & Scapagnini, G. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0070-3 · Cited by 122 · see citing works
Scassellati, C., Galoforo, A. C., Bonvicini, C., Esposito, C., & Ricevuti, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101138 · Cited by 121 · see citing works
Redox regulation of proteasome function
Lefaki, M., Papaevgeniou, N., & Chondrogianni, N. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.005 · Cited by 114 · see citing works
The aging brain: impact of heavy metal neurotoxicity
Ijomone, O. M., Ifenatuoha, C. W., Aluko, O. M., Ijomone, O. K., & Aschner, M. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1838441 · Cited by 116 · see citing works
Chen, N., Hu, M., Jiang, T., Xiao, P., & Duan, J. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122003 · Cited by 118 · see citing works
Liu, Y., Weng, W., Gao, R., & Liu, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4598167 · Cited by 116 · see citing works
4-hydroxynonenal-mediated signaling and aging
Zhang, H., & Forman, H. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.032 · Cited by 114 · see citing works
Self-citationVeith, C., Boots, A. W., Idris, M., van Schooten, F., & van der Vliet, A. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7742 · Cited by 113 · see citing works
Medina‐Reyes, E. I., Rodríguez‐Ibarra, C., Déciga‐Alcaraz, A., Díaz‐Urbina, D., Chirino, Y. I., & Pedraza‐Chaverrí, J. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111814 · Cited by 114 · see citing works
Purinergic signaling in the modulation of redox biology
Savio, L. E. B., Leite-Aguiar, R., Alves, V. S., Coutinho‐Silva, R., & Wyse, Â. T. D. S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102137 · Cited by 113 · see citing works
Zhang, Q., Zhao, Y., Talukder, M., Han, Y., Zhang, C., Li, X., & Li, J. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.09.211 · Cited by 112 · see citing works
Madkour, M. I., El-Serafi, A. T., Jahrami, H., Sherif, N. M., Hassan, R. E., Awadallah, S. M., & Faris, M. E. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107801 · Cited by 112 · see citing works
Erkens, R., Kramer, C. M., Lückstädt, W., Panknin, C., Krause, L., Weidenbach, M., Dirzka, J., Krenz, T., Mergia, E., Suvorava, T., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.10.409 · Cited by 108 · see citing works
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview
Martemucci, G., Portincasa, P., Ciaula, A. D., Mariano, M., Centonze, V., & D‘Alessandro, A. G. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111707 · Cited by 110 · see citing works
Rejuvenating Aged Bone Repair through Multihierarchy Reactive Oxygen Species‐Regulated Hydrogel
He, Z., Sun, C., Ma, Y., Chen, X., Wang, Y., Chen, K., Xie, F., Zhang, Y., Yuan, Y., & Liu, C. (2023) · Advanced Materials · doi:10.1002/adma.202306552 · Cited by 106 · see citing works
RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
Piras, S., Furfaro, A. L., Domenicotti, C., Traverso, N., Marinari, U. M., Pronzato, M. A., & Nitti, M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9348651 · Cited by 104 · see citing works
Luo, Z., Zhu, W. M., Guo, Q., Luo, W., Zhang, J., Xu, W., & Xu, J. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4768541 · Cited by 104 · see citing works
Oxidative stress: fundamentals and advances in quantification techniques
Krishnamurthy, H. K., Pereira, M., Rajavelu, I., Jayaraman, V., Krishna, K., Wang, T., Bei, K., & Rajasekaran, J. J. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1470458 · Cited by 116 · see citing works
The Proteasome and Oxidative Stress in Alzheimer's Disease
Bonet-Costa, V., Pomatto, L. C.-D., & Davies, K. J. A. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6802 · Cited by 99 · see citing works
Self-citationAlam, M. S., & Czajkowsky, D. M. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.11.001 · Cited by 101 · see citing works
Dual signaling evoked by oxidized LDLs in vascular cells
Nègre‐Salvayre, A., Augè, N., Camaré, C., Bacchetti, T., Ferretti, G., & Salvayre, R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.006 · Cited by 100 · see citing works
Ma, J., Li, S., Zhu, L., Guo, S., Yi, X., Cui, T., He, Y., Chang, Y., Liu, B., Li, C., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.421 · Cited by 100 · see citing works
Ren, P., Chen, J., Li, B., Zhang, M., Yang, B., Guo, X., Chen, Z., Cheng, H., Wang, P., Wang, S.-B., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3050971 · Cited by 100 · see citing works
Ferguson, G., & Bridge, W. J. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.01.017 · Cited by 99 · see citing works
Rana, A. K., & Singh, D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.006 · Cited by 99 · see citing works
Guo, K. X., Ge, J., Zhang, C., Lv, M., Zhang, Q., Talukder, M., & Li, J. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.125858 · Cited by 98 · see citing works
Das, T. K., & Ganesh, B. P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2206504 · Cited by 101 · see citing works
Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass
Ahn, B., Pharaoh, G. A., Premkumar, P., Huseman, K., Ranjit, R., Kinter, M. T., Szweda, L. I., Kiss, T., Fülöp, G. Á., Tarantini, S., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.004 · Cited by 94 · see citing works
The KEAP1-NRF2 System in Healthy Aging and Longevity
Matsumaru, D., & Motohashi, H. (2021) · Antioxidants · doi:10.3390/antiox10121929 · Cited by 99 · see citing works
Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response
Zhu, L., He, S., Huang, L. H., Ren, D., Nie, T., Tao, K. X., Li, X., Lu, F., Mao, Z., & Yang, Q. (2022) · Aging Cell · doi:10.1111/acel.13616 · Cited by 93 · see citing works
Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs
Paladino, S., Conte, A., Caggiano, R., Pierantoni, G. M., & Faraonio, R. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491465 · Cited by 92 · see citing works
Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer
Khurana, N., & Sikka, S. C. (2018) · Cancers · doi:10.3390/cancers10100352 · Cited by 91 · see citing works
Tang, C., Wang, X., Xie, Y., Cai, X., Yu, N. H., Hu, Y., & Zheng, Z. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495400 · Cited by 91 · see citing works
Involvement of Nrf2 in Ocular Diseases
Batliwala, S. Y., Xavier, C., Liu, Y., Wu, H., & Pang, I.-H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1703810 · Cited by 89 · see citing works
Khan, A. M., Korzeniowska, B., Gorshkov, V., Tahir, M., Schrøder, H. D., Skytte, L., Rasmussen, K. L., Khandige, S., Møller‐Jensen, J., & Kjeldsen, F. (2019) · Nanotoxicology · doi:10.1080/17435390.2018.1540728 · Cited by 89 · see citing works
Luo, Y., Li, X., Zhao, Y., Du, Z., & Li, J. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.02.142 · Cited by 89 · see citing works
A Pivotal Role of Nrf2 in Neurodegenerative Disorders: A New Way for Therapeutic Strategies
Süzen, S., Tucci, P., Profumo, E., Buttari, B., & Saso, L. (2022) · Pharmaceuticals · doi:10.3390/ph15060692 · Cited by 87 · see citing works
Zhang, W., Sun, X., Qi, X., Liu, X., Zhang, Y., Qiao, S., & Lin, H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05474 · Cited by 88 · see citing works
Redox mechanisms in age-related lung fibrosis
Kurundkar, A., & Thannickal, V. J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.06.005 · Cited by 88 · see citing works
Chen, Z., Yu, J., Fu, M., Dong, R., Yang, Y., Luo, J., Hu, S., Li, W., Xu, X., & Tu, L. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113951 · Cited by 85 · see citing works
Kwon, S., Lee, S. R., Park, Y. J., Ra, M., Lee, Y.-J., Pang, C., & Kim, K. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235832 · Cited by 85 · see citing works
Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function
Yang, Y., Luo, L., Cai, X., Fang, Y., Wang, J., Chen, G., Yang, J., Zhou, Q., Sun, X., Cheng, X., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.007 · Cited by 84 · see citing works
ROS networks: designs, aging, Parkinson’s disease and precision therapies
Kolodkin, A. N., Sharma, R. P., Colangelo, A. M., Ignatenko, A., Martorana, F., Jennen, D. G. J., Briedé, J. J., Brady, N. R., Barberis, M., Mondeel, T. D. G. A., et al. (2020) · npj Systems Biology and Applications · doi:10.1038/s41540-020-00150-w · Cited by 89 · see citing works
Wang, Z., Wang, L., Jiang, R., Li, C., Chen, X., Xiao, H., Hou, J., Hu, L., Huang, C., & Wang, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.08.007 · Cited by 83 · see citing works
Bono, S., Feligioni, M., & Corbo, M. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00479-8 · Cited by 83 · see citing works
- Authors
- Zhang, H., Davies, K. J. A., & Forman, H. J.
- Affiliations
- University of Southern California (US)
- University of California, Merced (US)
- Corresponding author
- Forman, Henry Jay
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 88
- Issue
- Pt B
- Pages
- 314-336
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC4628850
- OpenAlex
- W2207241376
- Cited by
- 804
- References
- 429
- Citations by year
- 2026: 50 · 2025: 56 · 2024: 75 · 2023: 94 · 2022: 111 · 2021: 92 · 2020: 103 · 2019: 76 · 2018: 56 · 2017: 47 · 2016: 32 · 2015: 12
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. NIH (R01-ES023864, R01-ES003598)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, aging, Nrf2 signaling, antioxidant response element, antioxidant enzymes, proteasome, age-related decline, post-translational regulation, age-related diseases
- MeSH terms
- Aging, Animals, Antioxidants, Gene Expression Regulation, Humans, Signal Transduction, Oxidative Stress, NF-E2-Related Factor 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review