Cited by 804Genomics, phytochemicals, and oxidative stressGenetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

Oxidative stress response and Nrf2 signaling in aging

Open access
Zhang, Hongqiao, Davies, Kelvin J.A., Forman, Henry Jay·2015·Free Radical Biology and Medicine

Abstract

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins, also decline. Importantly, the adaptive response to oxidative stress declines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels, including transcription, posttranslation, and interactions with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2015.05.036

Cites

423 of 423 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

5 retracted

Flagged first, then by citations

6 of the 429 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Zhang, H., Davies, K. J. A., & Forman, H. J.
Affiliations
  • University of Southern California (US)
  • University of California, Merced (US)
Corresponding author
Forman, Henry Jay
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2015-11
Volume
88
Issue
Pt B
Pages
314-336
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2207241376
Cited by
804
References
429
Citations by year
2026: 50 · 2025: 56 · 2024: 75 · 2023: 94 · 2022: 111 · 2021: 92 · 2020: 103 · 2019: 76 · 2018: 56 · 2017: 47 · 2016: 32 · 2015: 12
FWCI
4.70
Type
journal article
Language
en
Open access
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
U.S. NIH (R01-ES023864, R01-ES003598)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
oxidative stress, aging, Nrf2 signaling, antioxidant response element, antioxidant enzymes, proteasome, age-related decline, post-translational regulation, age-related diseases
MeSH terms
Aging, Animals, Antioxidants, Gene Expression Regulation, Humans, Signal Transduction, Oxidative Stress, NF-E2-Related Factor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review