The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bioavailability of rutin and quercetin in rats
Open accessAbstract
Quercetin is a powerful antioxidant which is widely distributed in edible plants, mainly as glycosides such as rutin. It has been reported to be absorbed in mammals, but its metabolism needs further investigation to evaluate its possible physiological effects. We compared the evolution of the absorption of quercetin and rutin in rats fed with supplemented diets. Rutin was absorbed more slowly than quercetin because it must be hydrolysed by the cecal microflora, whereas quercetin was absorbed from the small intestine. Conjugated derivatives of quercetin, and its methylated forms isorhamnetin and tamarixetin, were recovered in plasma from rats receiving the two kinds of experimental diets after the first meal, but after 10 days, no traces of tamarixetin were detected anymore. The rate of elimination of quercetin metabolites seems very low, and high plasma concentrations are easily maintained with a regular supply of quercetin or rutin in the diet.
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Hertog, M. G. L. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430040053006 · Cited by 1,853
Cited by
Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance
Bravo, L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01670.x · Cited by 4,030
Harwood, M., Danielewska-Nikiel, B., Borzelleca, J. F., Flamm, G. W., Williams, G. M., & Lines, T. C. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.05.015 · Cited by 889
Absorption and metabolism of flavonoids
Walle, T. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.002 · Cited by 622
Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
Manach, C., Morand, C., Crespy, V., Demigné, C., Texier, O., Régérat, F., & Rémésy, C. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00367-6 · Cited by 586
Self-citationKaume, L., Howard, L. R., & Devareddy, L. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203318p · Cited by 347
Metadata
- Authors
- Manach, C., Morand, C., Demigné, C., Texier, O., Régérat, F., & Rémésy, C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-06-02
- Volume
- 409
- Issue
- 1
- Pages
- 12-16
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2038890001
- Cited by
- 449
- References
- 1
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Manach, C., Morand, C., Demigné, C., Texier, O., Régérat, F., & Rémésy, C. (1997). Bioavailability of rutin and quercetin in rats. FEBS Letters. https://doi.org/10.1016/s0014-5793(97)00467-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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