The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
Abstract
Quercetin is one of the most abundant flavonoids in the human diet. This study aimed to determine the plasma concentrations of quercetin in 10 healthy volunteers after the consumption of a complex meal rich in plant products. Quercetin was determined in plasma (2 h before, and 3, 7 and 20 h after the meal), and in a duplicated portion of the meal by HPLC analysis with an electrochemical detection. The amount of ingested quercetin was estimated to be 87 mg. Before the meal, quercetin concentration in hydrolyzed plasmas ranged from 28 to 142 nM. A marked increase was observed 3 h after the meal in all subjects, with a mean concentration of 373 nM (S.E.M.=61). After 7 h, quercetin concentration in hydrolyzed plasmas decreased and after 20 h basal levels were found again. The antioxidant capacities of quercetin, 3′‐O‐methylquercetin, and of some of their conjugated derivatives were compared by the measurement of the conjugated dienes resulting from the Cu 2+‐induced oxidation of human LDL. 3′‐O‐Methylquercetin and conjugated derivatives of quercetin significantly prolonged the lag phase, but the magnitude of their effect was about half that of the aglycone.
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Cites
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Cited by
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Dietary polyphenols and the prevention of diseases
Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/1040869059096 · Cited by 2,999
Metadata
- Authors
- Manach, C., Morand, C., Crespy, V., Demigné, C., Texier, O., Régérat, F., & Rémésy, C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-04-24
- Volume
- 426
- Issue
- 3
- Pages
- 331-336
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2006949479
- Cited by
- 586
- References
- 24
- FWCI
- 26.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Manach, C., Morand, C., Crespy, V., Demigné, C., Texier, O., Régérat, F., & Rémésy, C. (1998). Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)00367-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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