Cited by 4,030Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietEdible Oils Quality and Analysis

The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

Bravo, Laura·2009·Nutrition Reviews

Abstract

Polyphenols constitute one of the most numerous and ubiquitous groups of plant metabolites and are an integral part of both human and animal diets. Ranging from simple phenolic molecules to highly polymerized compounds with molecular weights of greater than 30,000 Da, the occurrence of this complex group of substances in plant foods is extremely variable. Polyphenols traditionally have been considered antinutrients by animal nutritionists, because of the adverse effect of tannins, one type of polyphenol, on protein digestibility. However, recent interest in food phenolics has increased greatly, owing to their antioxidant capacity (free radical scavenging and metal chelating activities) and their possible beneficial implications in human health, such as in the treatment and prevention of cancer, cardiovascular disease, and other pathologies. Much of the literature refers to a single group of plant phenolics, the flavonoids. This review offers an overview of the nutritional effects of the main groups of polyphenolic compounds, including their metabolism, effects on nutrient bioavailability, and antioxidant activity, as well as a brief description of the chemistry of polyphenols and their occurrence in plant foods.

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Crossref · 10.1111/j.1753-4887.1998.tb01670.x

Cites

128 of 128 references verified0 citation errors · 0 not checkable

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  • Polyphenols can chelate transition metal cations (e.g., Cu2+ and Fe2+), thus preventing Haber-Weiss and Fenton reactions and inhibiting the activity of many enzymes involved in free radical generation.

    “Polyphenols can also chelate transition metal cations (e.g., Cu2+ and Fe2+), thus preventing Haber–Weiss and Fenton reactions (which lead to the generation of the extremely reactive hydroxyl radical •OH) and also inhibiting the activity of many enzymes involved in free radical generation (e.g., xanthine oxidase, protein kinase and lipoxygenase).”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [195]

Citations

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Research works printed but not linked: 21

  1. Harborne, 1989, Methods in plant biochemistry, I: plant phenolics
  2. Haslam, 1966, Vegetable tannins
  3. Würsch, 1984, The tannin granules from ripe carob pod, Lebens Wiss Technol, 17, 351
  4. Porter, 1989, Methods in plant biochemistry, I: plant phenolics, 389
  5. Ho, 1992, ACS Symposium Series 506
  6. Leth, 1998, Polyphenols in food, 39
  7. Bravo, 1993, Propiedades de los compuestos polifenólicos como constituyentes de la dieta: comparación con componentes de la fibra dietética [Doctoral dissertation]
  8. Bravo, 1996, Dietary fibre and fermentation in the colon, 181
  9. Saura-Calixto, 1996, Dietary fibre and fermentation in the colon, 87
  10. Hackett, 1986, Plant flavonoids in biology and medicine: biochemical, pharmacological, structure-activity relationships, 177
  11. Arrigoni, 1998, Polyphenols in food, 187
  12. Mañas, 1996, Dietary fibre and fermentation in the colon, 186
  13. Andary, 1998, Polyphenols in food, 41
  14. Mole S. Rogler JC Butler LG. Use of 15 N-labeled protein to determine the effect of dietary tannin on the relative abundance of endogenous and dietary protein in feces Proceedings of the Groupe Polyphenols XVth International Conference, 1990
  15. Charlton, 1998, Polyphenols in food, 179
  16. Ya, 1989, Chemistry and significance of condensed tannins, 307
  17. Régérat, 1992, Effects of condensed tannins and pectin on cecal fermentations and lipid metabolism in the rat, Bull Liaison Groupe Polyphenols, 16, 201
  18. Hurrell, 1998, Polyphenols in food, 169
  19. Jansman, 1993, Bioavailability 93: Nutritional, Chemical and Food Processing Implications of Nutrient Availability
  20. Coudray, 1998, Polyphenols in food, 173
  21. Torel, 1986, Antioxidant activity of flavoneids and reactivity with peroxyl radical, Phy-tochemistry, 25, 91

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Metadata

Authors
Bravo, L.
Affiliations
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
Bravo, Laura
Venue
Nutrition Reviews
Published
2009-04-27
Volume
56
Issue
11
Pages
317-333
ISSN
  • 0029-6643 (ISSN-L)
  • 1753-4887
OpenAlex
W1979189704
Cited by
4,030
References
128
Citations by year
2026: 52 · 2025: 87 · 2024: 131 · 2023: 181 · 2022: 168 · 2021: 187 · 2020: 241 · 2019: 206 · 2018: 221 · 2017: 212 · 2016: 194 · 2015: 217 · 2014: 237 · 2013: 214 · 2012: 198
FWCI
21.42
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords
polyphenols, flavonoids, tannins, polyphenol metabolism, food sources, plant-based foods, antioxidant activity, free radical scavenging, metal chelation, nutrient bioavailability, protein digestibility, antinutritional factors, cancer prevention, cardiovascular disease, human health
MeSH terms
Animals, Antioxidants, Biological Availability, Diet, Fermentation, Flavonoids, Humans, Minerals, Nutritional Physiological Phenomena, Phenols, Polymers, Tannins, Polyphenols

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