The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Repression of interleukin‐6 gene expression by 17β‐estradiol: inhibition of the DNA‐binding activity of the transcription factors NF‐IL6 and NF‐κB by the estrogen receptor
Open accessAbstract
The cytokine interleukin‐6 (IL‐6), a key mediator of immune and acute phase responses of the liver, has also been implicated in uterine functions. Estrogens are potent repressors of IL‐6 production by uterine stromal cells. In the endometrial adenocarcinoma cell line Ishikawa, phorbol ester‐induced activation of the IL‐6 promoter was inhibited to basal levels by 17β‐estradiol (E 2) in a wild‐type receptor‐dependent fashion. Although tamoxifen has been shown to have estrogenic effects on the endometrium, it did not inhibit induction of the IL‐6 promoter. We previously showed that inhibition of IL‐6 gene expression by E 2 does not involve high‐affinity binding of the estrogen receptor (ER) to IL‐6 DNA. We now report that the ER can directly interact with the transcription factors NF‐IL6 and NF‐κB and can inhibit their ability to bind DNA which might be the molecular basis for repression of IL‐6 gene expression by estrogens.
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Cites
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Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6
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Cited by
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation
Terry, C. F., Loukaci, V., & Green, F. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000379200 · Cited by 800
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz-Zagrosek, V., & Kararigas, G. (2017) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 732
Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences
Bramlett, H. M., & Dietrich, W. D. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000111614.19196.04 · Cited by 631
Marx, N., Sukhova, G. K., Collins, T., Libby, P., & Plutzky, J. (1999) · Circulation · doi:10.1161/01.cir.99.24.3125 · Cited by 599
Metadata
- Authors
- Ray, P., Ghosh, S. K., Zhang, D.-H., & Ray, A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-06-02
- Volume
- 409
- Issue
- 1
- Pages
- 79-85
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2193981851
- Cited by
- 256
- References
- 47
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Repression of interleukin‐6 gene expression by 17β‐estradiol: inhibition of the DNA‐binding activity of the transcription factors NF‐IL6 and NF‐κB by the estrogen receptor. https://app.cochat.ai/papers/10.1016/s0014-5793(97)00487-0
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- Ray, P., Ghosh, S. K., Zhang, D.-H., & Ray, A. (1997). Repression of interleukin‐6 gene expression by 17β‐estradiol: inhibition of the DNA‐binding activity of the transcription factors NF‐IL6 and NF‐κB by the estrogen receptor. FEBS Letters. https://doi.org/10.1016/s0014-5793(97)00487-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
