The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity
Abstract
Incubation of glutathione (GSH) depleted mouse erythrocytes with the oxidants phenylhydrazine, acrolein, divicine and isouramil resulted in the release of free iron and in lipid peroxidation and hemolysis. The addition of the flavonoid quercetin, which chelates iron and penetrates erythrocytes, resulted in remarkable protection against lipid peroxidation and hemolysis. The protection seems to be due to intracellular chelation of iron, since a semi‐stoichiometric ratio between released iron and the amount of quercetin necessary to prevent lipid peroxidation and hemolysis was found. Incubation of GSH depleted human erythrocytes with divicine and isouramil did not induce lipid peroxidation and hemolysis in spite of a substantial release of iron. However, divicine and isouramil produced alterations of membrane proteins, such as spectrin and band 3, as well as formation of senescent cell antigen. The addition of quercetin prevented these alterations.
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Cites
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
[43] Role of flavonoids and iron chelation in antioxidant action
Morel, I., Lescoat, G., Cillard, P., & Cillard, J. (1994) · Methods in Enzymology · doi:10.1016/0076-6879(94)34114-1 · Cited by 185
Cited by
Tungmunnithum, D., Thongboonyou, A., Pholboon, A., & Yangsabai, A. (2018) · Medicines · doi:10.3390/medicines5030093 · Cited by 1,969
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Flavonoids as Potential Anti-Inflammatory Molecules: A Review
Al-Khayri, J. M., Sahana, G. R., Nagella, P., Joseph, B. V., Alessa, F. M., & Al-Mssallem, M. Q. (2022) · Molecules · doi:10.3390/molecules27092901 · Cited by 1,100
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
RETRACTED: Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
Slika, H., Mansour, H., Wehbe, N., Nasser, S. A., Iratni, R., Nasrallah, G., Shaito, A., Ghaddar, T., Kobeissy, F., & Eid, A. H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112442 · Cited by 441
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Metadata
- Authors
- Ferrali, M., Signorini, C., Caciotti, B., Sugherini, L., Ciccoli, L., Giachetti, D., & Comporti, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-10-20
- Volume
- 416
- Issue
- 2
- Pages
- 123-129
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2042085844
- Cited by
- 367
- References
- 2
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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