RETRACTED: Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931 · see citing works

Flavonoids as Antioxidants

Pietta, P. (2000) · Journal of Natural Products · doi:10.1021/np9904509 · Cited by 4,881 · see citing works

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · see citing works

Flavonoids: a review of probable mechanisms of action and potential applications

Nijveldt, R. J., van Nood, E., van Hoorn, D. E. C., Boelens, P. G., van Norren, K., & van Leeuwen, P. A. M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,074 · see citing works

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899 · see citing works

Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality - a systematic review and dose-response meta-analysis of prospective studies

Aune, D., Giovannucci, E., Boffetta, P., Fadnes, L. T., Keum, N., Norat, T., Greenwood, D. C., Riboli, E., Vatten, L. J., & Tonstad, S. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyw319 · Cited by 2,419 · see citing works

Chemistry and biochemistry of dietary polyphenols

Tsao, R. (2010) · Nutrients · doi:10.3390/nu2121231 · Cited by 2,415 · see citing works

Flavonoids as antioxidants in plants: Location and functional significance

Agati, G., Azzarello, E., Pollastri, S., & Tattini, M. (2012) · Plant Science · doi:10.1016/j.plantsci.2012.07.014 · Cited by 2,146 · see citing works

ROS signalling in the biology of cancer

Moloney, J. N., & Cotter, T. G. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.023 · Cited by 1,982 · see citing works

Review of the biology of quercetin and related bioflavonoids

Formica, J. V., & Regelson, W. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(95)00077-1 · Cited by 1,764 · see citing works

[36] Flavonoids as antioxidants: Determination of radical-scavenging efficiencies

Bors, W., Heller, W. E., Michel, C., & Sarán, M. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86128-i · Cited by 1,726 · see citing works

Antioxidant and prooxidant properties of flavonoids

Procházková, D., Boušová, I., & Wilhelmová, N. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.01.018 · Cited by 1,572 · see citing works

Flavonoids as Anticancer Agents

Kopustinskienė, D. M., Jakštas, V., Savickas, A., & Bernatonienė, J. (2020) · Nutrients · doi:10.3390/nu12020457 · Cited by 1,313 · see citing works

Oxidative stress inhibits distant metastasis by human melanoma cells

Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269 · see citing works

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Son, Y., Cheong, Y.-K., Kim, N.-H., Chung, H.-T., Kang, D. G., & Pae, H.-O. (2011) · Journal of Signal Transduction · doi:10.1155/2011/792639 · Cited by 1,219 · see citing works

Flavonoids as Antioxidants

Jovanović, S. V., Steenken, S., Tošić, M., Marjanović, B., & Simic, M. G. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00090a032 · Cited by 1,197 · see citing works

Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties

Galati, G., & O'Brien, P. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.034 · Cited by 1,101 · see citing works

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., & Ohtsuki, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060868 · Cited by 1,099 · see citing works

Structure−Activity Relationship and Classification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers

Cos, P., Li, Y., Calomme, M. R., Hu, J., Cimanga, K., Poel, B. V., Pieters, L. A. C., Vlietinck, A. J., & Berghe, D. V. (1998) · Journal of Natural Products · doi:10.1021/np970237h · Cited by 1,092 · see citing works

Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity

Mira, L., Fernandez, M. T., Santos, M., Rocha, R., Florêncio, M. H., & Jennings, K. R. (2002) · Free Radical Research · doi:10.1080/1071576021000016463 · Cited by 1,055 · see citing works

NADPH oxidases: An overview from structure to innate immunity-associated pathologies

Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2014.89 · Cited by 944 · see citing works

Luteolin, a flavonoid, as an anticancer agent: A review

Imran, M., Rauf, A., Abu‐Izneid, T., Nadeem, M., Shariati, M. A., Khan, I. A., Imran, A., Orhan, İ. E., Rizwan, M., Atif, M., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108612 · Cited by 939 · see citing works

Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism

Moon, Y. J., Wang, X., & Morris, M. E. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.06.048 · Cited by 869 · see citing works

Antioxidants Accelerate Lung Cancer Progression in Mice

Sayin, V. I., Ibrahim, M. X., Larsson, E., Nilsson, J. A., Lindahl, P., & Bergo, M. O. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007653 · Cited by 867 · see citing works

TNF-α in promotion and progression of cancer

Balkwill, F. (2006) · Cancer Metastasis Review · doi:10.1007/s10555-006-9005-3 · Cited by 844 · see citing works

Natural Polyphenols for Prevention and Treatment of Cancer

Zhou, Y., Zheng, J., Li, Y., Xu, D.-P., Li, S., Chen, Y., & Li, H. (2016) · Nutrients · doi:10.3390/nu8080515 · Cited by 749 · see citing works

Antioxidants can increase melanoma metastasis in mice

Le Gal, K., Ibrahim, M. X., Wiel, C., Sayin, V. I., Akula, M. K., Karlsson, C., Dalin, M. G., Akyürek, L. M., Lindahl, P., Nilsson, J., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3740 · Cited by 632 · see citing works

Flavonoids as prospective compounds for anti-cancer therapy

Ravishankar, D., Rajora, A. K., Greco, F., & Osborn, H. M. I. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.10.004 · Cited by 573 · see citing works

Potential health impacts of excessive flavonoid intake

Skibola, C. F., & Smith, M. T. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00304-x · Cited by 567 · see citing works

Bioavailability of dietary flavonoids and phenolic compounds

Crozier, A., Rio, D. D., & Clifford, M. N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.007 · Cited by 550 · see citing works

Recent Advances in the Understanding of the Health Benefits and Molecular Mechanisms Associated with Green Tea Polyphenols

Xing, L., Zhang, H., Qi, R., Tsao, R., & Mine, Y. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b06146 · Cited by 547 · see citing works

Nuclear Factor-kappa B

Barnes, P. J. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(96)00159-8 · Cited by 498 · see citing works

Iron Chelation by the Powerful Antioxidant Flavonoid Quercetin

Leopoldini, M., Russo, N., Chiodo, S. G., & Toscano, M. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060986h · Cited by 488 · see citing works

Structure–radical scavenging activity relationships of flavonoids

Woldu, A. S., Asres, K., & El-Fiky, F. K. (2006) · Phytochemistry · doi:10.1016/j.phytochem.2006.07.002 · Cited by 466 · see citing works

Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury

Szöcs, K., Lassegue, B. P., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.102189 · Cited by 444 · see citing works

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

Zhao, J., Yang, J. H., & Xie, Y. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118642 · Cited by 422 · see citing works

A Quantum Chemical Explanation of the Antioxidant Activity of Flavonoids

van Acker, S. A. B. E., de Groot, M. J., van den Berg, D., Tromp, M. N. J. L., den Kelder, G. M. D.-O., van der Vijgh, W. J. F., & Bast, A. (1996) · Chemical Research in Toxicology · doi:10.1021/tx9600964 · Cited by 408 · see citing works

Flavanones: Citrus phytochemical with health‐promoting properties

Barreca, D., Gattuso, G., Bellocco, E., Calderaro, A., Trombetta, D., Smeriglio, A., Laganà, G., Daglia, M., Meneghini, S., & Nabavi, S. M. (2017) · BioFactors · doi:10.1002/biof.1363 · Cited by 385 · see citing works

Effects of low dose quercetin: Cancer cell‐specific inhibition of cell cycle progression

Jeong, J., An, J. Y., Kwon, Y. T., Rhee, J. G., & Lee, Y. J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21977 · Cited by 379 · see citing works

Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity

Ferrali, M., Signorini, C., Caciotti, B., Sugherini, L., Ciccoli, L., Giachetti, D., & Comporti, M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01182-4 · Cited by 367 · see citing works

Health-promoting effects of the citrus flavanone hesperidin

Li, C., & Schluesener, H. J. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.906382 · Cited by 357 · see citing works

Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase

Steffen, Y., Gruber, C., SCHEWE, T., & Sies, H. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.10.012 · Cited by 341 · see citing works

The role of antioxidant versus pro‐oxidant effects of green tea polyphenols in cancer prevention

Forester, S. C., & Lambert, J. D. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000641 · Cited by 334 · see citing works

Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription

O’Leary, K. A., de Pascual‐Teresa, S., Needs, P. W., Bao, Y., O’Brien, N. M., & Williamson, G. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.01.015 · Cited by 330 · see citing works

Inhibition of Mammalian Thioredoxin Reductase by Some Flavonoids: Implications for Myricetin and Quercetin Anticancer Activity

Lu, J., Papp, L. V., Fang, J., Rodriguez-Nieto, S., Zhivotovsky, B., & Holmgren, A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3310 · Cited by 326 · see citing works

Dietary Natural Products for Prevention and Treatment of Breast Cancer

Li, Y., Li, S., Meng, X., Gan, R., Zhang, J., & Li, H. (2017) · Nutrients · doi:10.3390/nu9070728 · Cited by 303 · see citing works

Flavonoids--food sources and health benefits.

Kozłowska, A., & Szostak-Węgierek, D. E. (2014) · PubMed · Cited by 294 · see citing works

Flavopiridol in Untreated or Relapsed Mantle-Cell Lymphoma: Results of a Phase II Study of the National Cancer Institute of Canada Clinical Trials Group

Kouroukis, C. T., Belch, A., Crump, M., Eisenhauer, E. A., Gascoyne, R. D., Meyer, R. M., Lohmann, R. C., Lopez, P., Powers, J., Turner, R. R., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.09.057 · Cited by 277 · see citing works

Flavonoid–drug interactions: Effects of flavonoids on ABC transporters

Morris, M. E., & Zhang, S. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.003 · Cited by 276 · see citing works

Facts and theories concerning the mechanisms of carcinogenesis

Pitot, H. C., & Dragan, Y. P. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.9.1860619 · Cited by 268 · see citing works

Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

Gibellini, L., Pinti, M., Nasi, M., Biasi, S. D., Roat, E., Bertoncelli, L., & Cossarizza, A. (2010) · Cancers · doi:10.3390/cancers2021288 · Cited by 264 · see citing works

Pro-oxidative activities and dose–response relationship of (−)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro

Li, G.-X., Chen, Y., Hou, Z., Xiao, H., Jin, H., Lu, G. G., Lee, M., Ba, L., Guan, F., Yang, Z., et al. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq039 · Cited by 237 · see citing works

Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9.

Suganuma, M., Okabe, S., Kai, Y., Sueoka, N., Sueoka, E., & Fujiki, H. (1999) · PubMed · Cited by 236 · see citing works

Phase II Study of Flavopiridol in Relapsed Chronic Lymphocytic Leukemia Demonstrating High Response Rates in Genetically High-Risk Disease

Lin, T. S., Ruppert, A. S., Johnson, A. J., Fischer, B., Heerema, N. A., Andritsos, L. A., Blum, K. A., Flynn, J. M., Jones, J. A., Hu, W., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.6944 · Cited by 225 · see citing works

Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management

Vargas, A. J., & Burd, R. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00301.x · Cited by 222 · see citing works

Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator‐activated receptor‐γ by flavonoids in mouse macrophages

Liang, Y., Tsai, S., Tsai, D.-C., Lin‐Shiau, S., & Lin, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02393-6 · Cited by 218 · see citing works

Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells

Qanungo, S., Das, M., Haldar, S., & Basu, A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi040 · Cited by 218 · see citing works

Flavopiridol, A Novel Cyclin-Dependent Kinase Inhibitor, in Metastatic Renal Cancer: A University of Chicago Phase II Consortium Study

Stadler, W. M., Vogelzang, N. J., Amato, R. J., Sosman, J. A., Taber, D. A., Liebowitz, D. N., & Vokes, E. E. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.2.371 · Cited by 210 · see citing works

Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes

Das, A., Banik, N. L., & Ray, S. K. (2009) · Cancer · doi:10.1002/cncr.24699 · Cited by 208 · see citing works

Flavonoids in hypertension: a brief review of the underlying mechanisms.

Maaliki, D., Shaito, A. A., Pintus, G., El-Yazbi, A., & Eid, A. (2019) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2019.04.014 · Cited by 208 · see citing works

Phase II Study of the Cyclin-Dependent Kinase Inhibitor Flavopiridol Administered to Patients With Advanced Gastric Carcinoma

Schwartz, G. K., Ilson, D. H., Saltz, L. B., O'Reilly, E. M., Tong, W. P., Maslak, P. G., Werner, J., Perkins, P., Stoltz, M., & Kelsen, D. P. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.7.1985 · Cited by 197 · see citing works

Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure

Mutoh, M. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.959 · Cited by 190 · see citing works

Induction of Apoptosis and Antiproliferative Activity of Naringenin in Human Epidermoid Carcinoma Cell through ROS Generation and Cell Cycle Arrest

Ahmad, M. S., Siddiqui, S., Jafri, A., Ahmad, S., Afzal, M., & Arshad, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110003 · Cited by 180 · see citing works

Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation

Mitra, S., Nguyen, L. N., Akter, M., Park, G., Choi, E. H., & Kaushik, N. K. (2019) · Cancers · doi:10.3390/cancers11071030 · Cited by 176 · see citing works

Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

Palit, S., Kar, S., Sharma, G., & Das, P. K. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24818 · Cited by 175 · see citing works

Flavonoid Basics: Chemistry, Sources, Mechanisms of Action, and Safety

Corcoran, M. P., McKay, D. L., & Blumberg, J. B. (2012) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2012.698219 · Cited by 173 · see citing works

Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells

Chung, L. Y., Cheung, T. C., Kong, S. K., Fung, K., Choy, Y. M., Chan, Z., & Kwok, T. T. (2001) · Life Sciences · doi:10.1016/s0024-3205(00)01020-1 · Cited by 172 · see citing works

Green Tea Component, Catechin, Induces Apoptosis of Human Malignant B Cells via Production of Reactive Oxygen Species

Nakazato, T., Ito, K., Ikeda, Y., & Kizaki, M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2273 · Cited by 168 · see citing works

Naringenin‐Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways

Lim, W., Park, S., Bazer, F. W., & Song, G. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25729 · Cited by 168 · see citing works

Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone

Ismail, H., Shakkour, Z., Tabet, M., Abdelhady, S., Kobaisi, A., Abedi, R., Nasrallah, L., Pintus, G., Al-Dhaheri, Y., Mondello, S., et al. (2020) · Antioxidants · doi:10.3390/antiox9100943 · Cited by 167 · see citing works

Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells

Kang, K. A., Piao, M. J., Ryu, Y. S., Hyun, Y. J., Park, J. E., Shilnikova, K., Zhen, A. X., Kang, H. K., Koh, Y. S., Jeong, Y. J., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4091 · Cited by 166 · see citing works

Effects of Tea Polyphenols on the Invasion and Matrix Metalloproteinases Activities of Human Fibrosarcoma HT1080 Cells

Maeda‐Yamamoto, M., Kawahara, H., Tahara, N., Tsuji, K., Hara, Y., & Isemura, M. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9811525 · Cited by 165 · see citing works

Determination of polyphenolic compounds by liquid chromatography–mass spectrometry in Thymus species

Boros, B., Jakabová, S., Dörnyei, Á., Horváth, G., Pluhár, Z., Kilár, F., & Felinger, A. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.07.042 · Cited by 164 · see citing works

Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation

Shukla, S., & Gupta, S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.007 · Cited by 162 · see citing works

Redox control in cancer development and progression

Helfinger, V., & Schröder, K. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.02.003 · Cited by 152 · see citing works

Intracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomes

Rezaei-Sadabady, R., Eidi, A., Zarghami, N., & Barzegar, A. (2014) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2014.926456 · Cited by 144 · see citing works

Pro-oxidative Properties of Flavonoids in Human Lymphocytes

Yen, G., Duh, P., Hui-Ling, T. S. A. I., & Huang, S.-L. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.1215 · Cited by 142 · see citing works

Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies

Chang, H., Lei, L., Zhou, Y., Ye, F., & Zhao, G. (2018) · Nutrients · doi:10.3390/nu10070950 · Cited by 140 · see citing works

Physiological roles of matrix metalloproteinases: implications for tumor growth and metastasis

Forget, M.-A., Desrosiers, R. R., & Béliveau, R. (1999) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y99-055 · Cited by 139 · see citing works

Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice

Kamaraj, S., Ramakrishnan, G., Anandakumar, P., Sundaram, J., & Devaki, T. (2008) · Investigational New Drugs · doi:10.1007/s10637-008-9159-7 · Cited by 137 · see citing works

Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells

Xu, Y., Xin, Y., Diao, Y., Lu, C., Fu, J., Luo, L., & Yin, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029169 · Cited by 137 · see citing works

Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells.

Fujiki, H., Watanabe, T., Sueoka, E., Rawangkan, A., & Suganuma, M. (2018) · PubMed Central · doi:10.14348/molcells.2018.2227 · Cited by 137 · see citing works

The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells

Hwang, Y. P., Oh, K. N., Yun, H. J., & Jeong, H. G. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.10.016 · Cited by 132 · see citing works

Different antitumor effects of quercetin, quercetin-3′-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells

Wu, Q., Needs, P. W., Lu, Y., Kroon, P. A., Ren, D., & Yang, X. (2018) · Food & Function · doi:10.1039/c7fo01964e · Cited by 131 · see citing works

Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells

Badran, A., Nasser, S. A., Mesmar, J. E., EL‐Yazbi, A. F., Bitto, A., Fardoun, M., Baydoun, E., & Eid, A. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228764 · Cited by 126 · see citing works

Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma

Wang, Q., Wang, H., Jia, Y., Pan, H., & Ding, H. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3299-4 · Cited by 124 · see citing works

Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis

Leung, H. W.-C., Kuo, C., Yang, W., Lin, C.-H., & Lee, H. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.01.021 · Cited by 120 · see citing works

Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis

Shi, M., Shiao, C.-K., Lee, Y., & Shih, Y. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0186-0 · Cited by 117 · see citing works

A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis

Thuan, D. T. B., Zayed, H., Eid, A. H., Abou-Saleh, H., Nasrallah, G. K., Mangoni, A. A., & Pintus, G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01985 · Cited by 114 · see citing works

Reactive Oxygen Species Induce Epigenetic Instability through the Formation of 8-Hydroxydeoxyguanosine in Human Hepatocarcinogenesis

Nishida, N., Arizumi, T., Takita, M., Kitai, S., Yada, N., Hagiwara, S., Inoue, T., Minami, Y., Ueshima, K., Sakurai, T., et al. (2013) · Digestive Diseases · doi:10.1159/000355245 · Cited by 113 · see citing works

Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

Wang, Y., Yu, H., Zhang, J., Gao, J., Ge, X., & Lou, G. (2015) · BMC Cancer · doi:10.1186/s12885-015-1706-y · Cited by 110 · see citing works

Antioxidant capacity of hesperidin fromCitruspeel using electron spin resonance and cytotoxic activity against human carcinoma cell lines

Al-Ashaal, H. A., & El-Sheltawy, S. T. (2011) · Pharmaceutical Biology · doi:10.3109/13880209.2010.509734 · Cited by 109 · see citing works

Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity

Weng, C., Chen, M.-J., Yeh, C., & Yen, G. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.05.003 · Cited by 106 · see citing works

Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

Li, Z., Cheng, X. F., Gao, Y., Zheng, J., Xu, Q., Sun, Y., Guan, H., Yu, H., & Sun, Z. (2015) · Food & Function · doi:10.1039/c5fo00671f · Cited by 105 · see citing works

Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells

Shang, H., Lu, H., Lee, C., Chiang, H., Chu, Y., Chen, A., Lin, Y., & Chung, J. (2018) · Environmental Toxicology · doi:10.1002/tox.22623 · Cited by 105 · see citing works

Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression

Raja, S. B., Rajendiran, V., Kasinathan, N. K., Amrithalakshmi, P., Venkatabalasubramanian, S., Murali, M. R., Devaraj, H., & Devaraj, S. N. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.006 · Cited by 104 · see citing works

Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells

Park, H. J., Choi, Y. J., Lee, J. H., & Nam, M. J. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.11.008 · Cited by 103 · see citing works

Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production

Zhang, X., Huang, J., Yu, C., Xiang, L., Li, L., Shi, D., & Lin, F. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s228453 · Cited by 103 · see citing works

Association of Suppression of Extracellular Signal-Regulated Kinase Phosphorylation by Epigallocatechin Gallate with the Reduction of Matrix Metalloproteinase Activities in Human Fibrosarcoma HT1080 Cells

Maeda‐Yamamoto, M., Suzuki, N., Sawai, Y., Miyase, T., Sano, M., Hashimoto-Ohta, A., & Isemura, M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf021039l · Cited by 101 · see citing works

Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species

Zhang, J., Wu, D., Vikash, V., Song, J. T., Wang, J., Yi, J., & Dong, W. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3696-7 · Cited by 95 · see citing works

Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells

Kim, G. T., Lee, S. H., & Kim, Y. M. (2013) · Journal of Cancer Prevention · doi:10.15430/jcp.2013.18.3.264 · Cited by 92 · see citing works

Mechanisms underlying the xanthine oxidase inhibitory effects of dietary flavonoids galangin and pinobanksin

Dong, Y., Huang, H., Zhao, M., Sun‐Waterhouse, D., Lin, L., & Xiao, C. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.03.021 · Cited by 92 · see citing works

The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells

Lee, K.-H., Yeh, M.-H., Kao, S.-T., Hung, C.-M., Liu, C.-J., Huang, Y.-Y., & Yeh, C.-C. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.01.021 · Cited by 91 · see citing works

The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin‐mediated cell death of human prostate cancer PC‐3 cells

Liu, K.-C., Yen, C., Wu, R. S., Yang, J., Lu, H., Lu, K.-W., Lo, C., Chen, H., Tang, N.-Y., Wu, C., et al. (2012) · Environmental Toxicology · doi:10.1002/tox.21769 · Cited by 90 · see citing works

Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling

Fan, J.-J., Hsu, W.-H., Lee, K., Chen, K., Lin, C., Lee, Y.-L., Ko, T., Lee, L.-T., Lee, M., Chang, M.-S., et al. (2019) · Antioxidants · doi:10.3390/antiox8110557 · Cited by 90 · see citing works

Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway

Iida, K., Naiki, T., Naiki‐Ito, A., Suzuki, S., Kato, H., Nozaki, S., Nagai, T., Etani, T., Nagayasu, Y., Ando, R., et al. (2020) · Cancer Science · doi:10.1111/cas.14334 · Cited by 90 · see citing works

Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting

Seydi, E., Salimi, A., Rasekh, H. R., Mohsenifar, Z., & Pourahmad, J. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1460679 · Cited by 89 · see citing works

Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update

Malik, A., Sultana, M., Qazi, A. M., Qazi, M. H., Parveen, G., Waquar, S., Ashraf, A. B., & Rasool, M. (2016) · Analytical Cellular Pathology · doi:10.1155/2016/6146595 · Cited by 88 · see citing works

Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line – A comparative study

Gunasekaran, S., Rajamanickam, V., Preethy, C. P., Riyasdeen, A., Akbarsha, M. A., Menon, V. P., & Nalini, N. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.11.038 · Cited by 85 · see citing works

Targeting Reactive Oxygen Species in Cancer via Chinese Herbal Medicine

Qian, Q., Chen, W., Cao, Y., Cao, Q., Cui, Y., Li, Y., & Wu, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9240426 · Cited by 84 · see citing works

Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives

Salmani, J. M. M., Zhang, X., Jacob, J. A., & Chen, B. (2017) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(17)30052-3 · Cited by 83 · see citing works

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

Granato, M., Montani, M. S. G., Santarelli, R., D’Orazi, G., Faggioni, A., & Cirone, M. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0632-z · Cited by 83 · see citing works

Nomenclature of flavonoids (IUPAC Recommendations 2017)

Rauter, A. P., Ennis, M., Hellwich, K., Herold, B. J., Horton, D., Moss, G. P., & Schomburg, I. (2018) · Pure and Applied Chemistry · doi:10.1515/pac-2013-0919 · Cited by 83 · see citing works

Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival

Posadino, A. M., Giordo, R., Cossu, A., Nasrallah, G. K., Shaito, A. A., Abou-Saleh, H., Eid, A. H., & Pintus, G. (2019) · Biomolecules · doi:10.3390/biom9060209 · Cited by 82 · see citing works

Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression

Bodduluru, L. N., Kasala, E. R., Madhana, R. M., Barua, C. C., Hussain, M. I., Haloi, P., & Borah, P. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.11.036 · Cited by 81 · see citing works

Raynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms

Fardoun, M. M., Nassif, J., Issa, K., Baydoun, E., & Eid, A. H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00438 · Cited by 80 · see citing works

Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats

Arul, D., & Subramanian, P. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.039 · Cited by 79 · see citing works

Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells

Yeh, M.-H., Kao, S.-T., Hung, C.-M., Liu, C.-J., Lee, K.-H., & Yeh, C.-C. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.11.018 · Cited by 78 · see citing works

Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice

Bodduluru, L. N., Kasala, E. R., Barua, C. C., Karnam, K. C., Dahiya, V., & Ellutla, M. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.10.020 · Cited by 78 · see citing works

Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells

Ahmadi, A., Hosseinimehr, S. J., Naghshvar, F., Hajir, E., & Ghahremani, M. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-1228-z · Cited by 77 · see citing works

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets

Fardoun, M., Maaliki, D. S., Halabi, N., Iratni, R., Bitto, A., Baydoun, E., & Eid, A. H. (2020) · Clinical Science · doi:10.1042/cs20200356 · Cited by 76 · see citing works

Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways

Lu, H.-F., Chie, Y.-J., Yang, M.-S., Lu, K.-W., Fu, J.-J., Yang, J., Chen, H.-Y., Hsia, T., Ma, C.-Y., Ip, S., et al. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110386258 · Cited by 72 · see citing works

Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF‐α expression

Suganuma, M., Sueoka, E., Sueoka, N., Okabe, S., & Fujiki, H. (2000) · BioFactors · doi:10.1002/biof.5520130112 · Cited by 71 · see citing works

5‐Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)‐mediated apoptosis in hepatocellular carcinoma

Hu, X., Liang, J., Guo, X., Liu, L., & Guo, Y. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12333 · Cited by 70 · see citing works

Luteoloside induces G0/G1 arrest and pro-death autophagy through the ROS-mediated AKT/mTOR/p70S6K signalling pathway in human non-small cell lung cancer cell lines

Zhou, M., Shen, S., Zhao, X., & Gong, X. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.042 · Cited by 69 · see citing works

Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells

Ersöz, M., Erdemir, A. D., Duranoğlu, D., Uzunoglu, D., Arasoğlu, T., Derman, S., & Mansuroğlu, B. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1556213 · Cited by 69 · see citing works

Suppression of Human Pancreatic Carcinoma Cell Growth and Invasion by Epigallocatechin-3-Gallate

Takada, M., Nakamura, Y., Koizumi, T., Toyama, H., Kamigaki, T., Suzuki, Y., Takeyama, Y., & Kuroda, Y. (2002) · Pancreas · doi:10.1097/00006676-200207000-00012 · Cited by 68 · see citing works

Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway

Sun, Q., Lu, N.-N., & Feng, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.009 · Cited by 67 · see citing works

Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2

Jeon, J.-S., Kwon, S., Ban, K., Hong, Y. K., Ahn, C., Sung, J., & Choi, I. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2018.1559929 · Cited by 67 · see citing works

Antithrombotic activity of flavonoids and polyphenols rich plant species

Bojić, M., Maleš, Ž., Antolić, A., Babić, I., & Tomičić, M. (2019) · Acta Pharmaceutica · doi:10.2478/acph-2019-0050 · Cited by 67 · see citing works

Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB

Lee, M. H., Han, D., Hyon, S.-H., & Park, J. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0548-y · Cited by 56 · see citing works

A naringenin–tamoxifen combination impairs cell proliferation and survival of MCF-7 breast cancer cells

Hatkevich, T., Ramos, J., Santos-Sanchez, I., & Patel, Y. M. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.05.017 · Cited by 56 · see citing works

Effect of hesperidin on matrix metalloproteinases and antioxidant status during nicotine-induced toxicity

Balakrishnan, A., & Menon, V. P. (2007) · Toxicology · doi:10.1016/j.tox.2007.04.022 · Cited by 56 · see citing works

The NADPH Oxidase Nox4 mediates tumour angiogenesis

Helfinger, V., Henke, N., Harenkamp, S., Walter, M., Epah, J., Penski, C., Mittelbronn, M. G. A., & Schröder, K. (2015) · Acta Physiologica · doi:10.1111/apha.12625 · Cited by 55 · see citing works

(-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial–mesenchymal transition via NF-κB p65 inactivation

Li, Y., Wu, S., Lu, S., Chen, F., Guo, Y., Gan, S.-M., Shi, Y., Liu, S., & Li, S. (2014) · Tumor Biology · doi:10.1007/s13277-014-2899-4 · Cited by 55 · see citing works

Naringenin suppresses growth of human placental choriocarcinoma via reactive oxygen species-mediated P38 and JNK MAPK pathways

Park, S., Lim, W., Bazer, F. W., & Song, G. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.08.026 · Cited by 55 · see citing works

Anti-Cancer Effects of Green Tea by Either Anti- or Pro-Oxidative Mechanisms

Hayakawa, S., Saito, K., Miyoshi, N., Ohishi, T., Oishi, Y., Miyoshi, M., & Nakamura, Y. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2016.17.4.1649 · Cited by 54 · see citing works

Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention

Maurya, A. K., & Vinayak, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-3634-5 · Cited by 53 · see citing works

Luteolin acts as a radiosensitizer in non-small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade

Cho, H.-J., Ahn, K.-C., Choi, J. Y., Hwang, S., Kim, W., Um, H., & Park, J. K. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2831 · Cited by 53 · see citing works

Apigenin affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line

Bruno, A., Siena, L., Gerbino, S., Ferraro, M., Chanez, P., Giammanco, M., Gjomarkaj, M., & Pace, E. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.03.034 · Cited by 53 · see citing works

Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme

Poór, M., Boda, G., Needs, P. W., Kroon, P. A., Lemli, B., & Bencsik, T. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.092 · Cited by 53 · see citing works

Supplementation of Jurkat T Cells with Green Tea Extract Decreases Oxidative Damage Due to Iron Treatment

Erba, D., Riso, P., Colombo, A., & Testolin, G. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2130 · Cited by 51 · see citing works

Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging

Hernaez, J. F., Xu, M., & Dashwood, R. H. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00309-6 · Cited by 51 · see citing works

The ROS-KRAS-Nrf2 axis in the control of the redox homeostasis and the intersection with survival-apoptosis pathways: Implications for photodynamic therapy

Ferino, A., Rapozzi, V., & Xodo, L. E. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111672 · Cited by 51 · see citing works

Western diet aggravates neuronal insult in post-traumatic brain injury: Proposed pathways for interplay

Shaito, A. A., Hasan, H. A., Habashy, K. J., Fakih, W., Abdelhady, S., Ahmad, F., Zibara, K., Eid, A. H., EL‐Yazbi, A. F., & Kobeissy, F. H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102829 · Cited by 50 · see citing works

Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System

Bugel, S. M., Bonventre, J. A., & Tanguay, R. L. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw139 · Cited by 49 · see citing works

Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Choudhary, S., Sood, S., Donnell, R. L., & Wang, H. R. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs097 · Cited by 48 · see citing works

Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species

Kittiratphatthana, N., Kukongviriyapan, V., Prawan, A., & Senggunprai, L. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12586 · Cited by 48 · see citing works

Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes

Xu, Z., Huang, B., Liu, J., Wu, X., Luo, N., Wang, X., Zheng, X., & Pan, X. (2018) · Toxicology · doi:10.1016/j.tox.2018.08.013 · Cited by 48 · see citing works

Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria

Seydi, E., Rasekh, H. R., Salimi, A., Mohsenifar, Z., & Pourahmad, J. (2016) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520616666160425110839 · Cited by 47 · see citing works

The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy

Bhagani, H., Nasser, S. A., Dakroub, A. H., EL‐Yazbi, A. F., Eid, A. A., Kobeissy, F. H., Pintus, G., & Eid, A. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144962 · Cited by 45 · see citing works

The Role of Epac in Cancer Progression

Wehbe, N., Slika, H., Mesmar, J. E., Nasser, S. A., Pintus, G., Baydoun, S. E., Badran, A., Kobeissy, F. H., Eid, A. H., & Baydoun, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186489 · Cited by 45 · see citing works

Chemiluminescence analysis of the prooxidant and antioxidant effects of epigallocatechin-3-gallate.

Tian, B., Sun, Z., Xu, Z.-J., & Hua, Y. (2007) · PubMed · Cited by 43 · see citing works

Molecular displacement of warfarin from human serum albumin by flavonoid aglycones

Poór, M., Li, Y., Kunsági‐Máté, S., Petrik, J., Vladimir‐Knežević, S., & Kőszegi, T. (2013) · Journal of Luminescence · doi:10.1016/j.jlumin.2013.03.056 · Cited by 40 · see citing works

Paradoxical Effects of Antioxidants on Cancer

Mendelsohn, A. R., & Larrick, J. W. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1577 · Cited by 36 · see citing works

Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2

Naji, S. M., Issa, K., Eid, A. A., Iratni, R., & Eid, A. H. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000106 · Cited by 35 · see citing works

The Stability and Activity Changes of Apigenin and Luteolin in Human Cervical Cancer Hela Cells in Response to Heat Treatment and Fe2+/Cu2+ Addition

Liu, W.-N., Shi, J., Fu, Y., & Zhao, X. (2019) · Foods · doi:10.3390/foods8080346 · Cited by 35 · see citing works

Protection by Quercetin Against Cooking Oil Fumes-Induced DNA Damage in Human Lung Adenocarcinoma CL-3 Cells: Role of COX-2

Lin, S., Tsai, S.-J., Wang, L.-H., Wu, M., & Lee, H. (2002) · Nutrition and Cancer · doi:10.1207/s15327914nc441_13 · Cited by 33 · see citing works

Lethal and teratogenic effects of naringenin evaluated by means of an amphibian embryo toxicity test (AMPHITOX)

Pérez‐Coll, C. S., & Herkovits, J. (2003) · Food and Chemical Toxicology · doi:10.1016/j.fct.2003.09.004 · Cited by 33 · see citing works

MODULATORY EFFECT OF NARINGENIN ONN‐METHYL‐N′‐NITRO‐N‐NITROSOGUANIDINE‐ AND SATURATED SODIUM CHLORIDE‐INDUCED GASTRIC CARCINOGENESIS IN MALE WISTAR RATS

Ganapathy, E., Rajendran, P., Rajasekaran, D., Magesh, V., & Sakthisekaran, D. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04987.x · Cited by 32 · see citing works

Prevention of oxidative DNA damage in inner organs and lymphocytes of rats by green tea extract

Kager, N., Ferk, F., Kundi, M., Wagner, K., Mišík, M., & Knasmüller, S. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0068-0 · Cited by 32 · see citing works

Ziziphus nummularia Attenuates the Malignant Phenotype of Human Pancreatic Cancer Cells: Role of ROS

Mesmar, J. E., Fardoun, M., Abdallah, R., Dhaheri, Y. A., Yassine, H. M., Iratni, R., Badran, A., Eid, A. H., & Baydoun, E. (2021) · Molecules · doi:10.3390/molecules26144295 · Cited by 32 · see citing works

Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer

Pal, M. K., Jaiswar, S. P., Dwivedi, A., Goyal, S., Dwivedi, V., Pathak, A. K., Kumar, V., Sankhwar, P., & Ray, R. S. (2017) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520617666170425094549 · Cited by 30 · see citing works

Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis via enhancement of oxidative stress in human colorectal cancer SW620 cells

Zhang, Y., Guo, Y.-C., Wang, M., Dong, H., Zhang, J., & Zhang, L. (2017) · Oncology Reports · doi:10.3892/or.2017.6042 · Cited by 29 · see citing works

Cytotoxic Effects of Some Flavonoids and Imatinib on the K562 Chronic Myeloid Leukemia Cell Line: Data Analysis Using the Combination Index Method

Kalındemirtaş, F. D., Birman, H., Çandöken, E., Gazioğlu, S. B., Melikoğlu, G., & Kuruca, S. E. (2019) · Balkan Medical Journal · doi:10.4274/balkanmedj.galenos.2018.2017.1244 · Cited by 29 · see citing works

Ziziphus nummularia Inhibits Inflammation‐Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells

Fardoun, M., Shehabi, T. S. A., EL‐Yazbi, A. F., Issa, K., Zouein, F. A., Maaliki, D. S., Iratni, R., & Eid, A. H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4134093 · Cited by 27 · see citing works

Toxicological aspects of flavonoid interaction with biomacromolecules.

Hodek, P., Hanuštiak, P., Křížková, J., Mikelová, R., Křížková, S., Stiborová, M., Trnková, L., Horna, A., Beklová, M., & Kizek, R. (2006) · PubMed · Cited by 23 · see citing works

Simultaneous preparation of naturally abundant and rare catechins by tannase-mediated biotransformation combining high speed counter current chromatography

Xia, G., Hong, S., & Liu, S. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.11.090 · Cited by 22 · see citing works

Repurposing Cilostazol for Raynaud's Phenomenon

El-Hachem, N., Fardoun, M., Slika, H., Baydoun, E., & Eid, A. H. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200903114154 · Cited by 16 · see citing works

Cerebral Ischemia and Inflammation

Iadecola, C., Cho, S., Feuerstein, G., & Hallenbeck, J. M. (2004) · Elsevier eBooks · doi:10.1016/b0-44-306600-0/50052-3 · Cited by 16 · see citing works

Teratogenic effect of hydroxyethylrutoside, a flavonoid derivate drug – a population-based case–control study

Pósfai, É., Bánhidy, F. G., & Czeizel, A. E. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.850485 · Cited by 11 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Naringenin: A potential flavonoid phytochemical for cancer therapy

Motallebi, M., Bhia, M., Rajani, H. F., Bhia, I., Tabarraei, H., Mohammadkhani, N., Pereira‐Silva, M., Kasaii, M. S., Nouri-Majd, S., Mueller, A., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120752 · Cited by 336 · see citing works

Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine

Zahra, M., Abrahamse, H., & George, B. P. A. (2024) · Antioxidants · doi:10.3390/antiox13080922 · Cited by 259 · see citing works

Oxidative stress in cancer: from tumor and microenvironment remodeling to therapeutic frontiers

Liang, X., Weng, J., You, Z., Wang, Y., Wen, J., Xia, Z., Huang, S., Luo, P., & Cheng, Q. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02375-x · Cited by 182 · see citing works

Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability

Hu, L., Luo, Y., Yang, J., & Cheng, C. (2025) · Molecules · doi:10.3390/molecules30051184 · Cited by 169 · see citing works

Therapeutic Potential of Luteolin on Cancer

Çetinkaya, M., & Baran, Y. (2023) · Vaccines · doi:10.3390/vaccines11030554 · Cited by 145 · see citing works

Flavonoids as Promising Natural Compounds in the Prevention and Treatment of Selected Skin Diseases

Čižmárová, B., Hubková, B., Tomečková, V., & Birková, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076324 · Cited by 145 · see citing works

Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

Mokrá, D., Adamčáková, J., & Mokrý, J. (2022) · Antioxidants · doi:10.3390/antiox11081566 · Cited by 119 · see citing works

Chemico-biological aspects of (−)- epigallocatechin- 3 -gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects

Sahadevan, R., Singh, S. K., Binoy, A., & Sadhukhan, S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2068500 · Cited by 102 · see citing works

Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)

Šamec, D., Karalija, E., Dahija, S., & Hassan, S. T. S. (2022) · Plants · doi:10.3390/plants11101381 · Cited by 100 · see citing works

Antioxidants in brain tumors: current therapeutic significance and future prospects

Qi, X., Jha, S. K., Jha, N. K., Dewanjee, S., Dey, A., Deka, R., Pritam, P., Ramgopal, K., Liu, W.-T., & Hou, K. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01668-9 · Cited by 100 · see citing works

Biochemical and cellular basis of oxidative stress: Implications for disease onset

Aramouni, K., Assaf, R., Shaito, A. A., Fardoun, M., Al‐Asmakh, M., Sahebkar, A., & Eid, A. H. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31071 · Cited by 90 · see citing works

Chemistry of lignin and condensed tannins as aromatic biopolymers

Seidi, F., Liu, Y., Huang, Y., Xiao, H., & Crespy, D. (2025) · Chemical Society Reviews · doi:10.1039/d4cs00440j · Cited by 86 · see citing works

Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate

Zhang, S., Mao, B., Cui, S., Zhang, Q., Zhao, J., Tang, X., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2170972 · Cited by 81 · see citing works

Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment

Zhang, J., Xu, H., Zhu, J., Dou, Y., Xian, Y., & Lin, Z. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82401 · Cited by 70 · see citing works

Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review

Muchtaridi, M., Az-Zahra, F., Wongso, H., Setyawati, L. U., Novitasari, D., & Ikram, E. H. K. (2024) · Antioxidants · doi:10.3390/antiox13020207 · Cited by 68 · see citing works

Flavonoids with Anti-Angiogenesis Function in Cancer

Wei, Q., & Zhang, Y. (2024) · Molecules · doi:10.3390/molecules29071570 · Cited by 62 · see citing works

Oxidative stress affects the beginning of the growth of cancer cells through a variety of routes

Saleh, E. A. M., Al-dolaimy, F., Almajidi, Y. Q., Baymakov, S. R., Mohammed Abdul Kader, M., Ullah, M. I., Abbas, A., Khlewee, I. H., Bisht, Y. S., & Alsaalamy, A. H. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154664 · Cited by 61 · see citing works

Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease

Jarmakiewicz-Czaja, S., Ferenc, K., & Filip, R. (2023) · Metabolites · doi:10.3390/metabo13040573 · Cited by 58 · see citing works

Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin

Hasan, A. A., Tatarskiy, V. V., & Kalinina, E. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214413 · Cited by 60 · see citing works

Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy

Dewanjee, S., Chakraborty, P., Bhattacharya, H., Singh, S. K., Dua, K., Dey, A., & Jha, N. K. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103409 · Cited by 56 · see citing works

Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review

Drețcanu, G., Ştirbu, I., Leoplold, N., Cruceriu, D., Danciu, C., Stănilă, A., Fărcaș, A. C., Borda, I. M., Iuhas, C. I., & Diaconeasa, Z. M. (2022) · Plants · doi:10.3390/plants11091117 · Cited by 54 · see citing works

Specificity Proteins (Sp) and Cancer

Safe, S. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065164 · Cited by 53 · see citing works

Flavonoids, gut microbiota and cardiovascular disease: Dynamics and interplay

Mansour, H., Slika, H., Nasser, S. A., Pintus, G., Khachab, M. Y., Sahebkar, A., & Eid, A. H. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107452 · Cited by 53 · see citing works

Apigetrin Promotes TNFα-Induced Apoptosis, Necroptosis, G2/M Phase Cell Cycle Arrest, and ROS Generation through Inhibition of NF-κB Pathway in Hep3B Liver Cancer Cells

Bhosale, P. B., Abusaliya, A., Kim, H. H., Ha, S. E., Park, M. Y., Jeong, S. H., Vetrivel, P., Heo, J., Kim, J., Won, C. K., et al. (2022) · Cells · doi:10.3390/cells11172734 · Cited by 52 · see citing works

Anti-Cancer Effects of Dietary Polyphenols via ROS-Mediated Pathway with Their Modulation of MicroRNAs

Yoshioka, Y., Ohishi, T., Nakamura, Y., Fukutomi, R., & Miyoshi, N. (2022) · Molecules · doi:10.3390/molecules27123816 · Cited by 50 · see citing works

Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease

Fu, W., Huang, Z., Li, W., Xu, L., Yang, M., Ma, Y., Liu, H., Qian, H., & Wang, W. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.12.004 · Cited by 54 · see citing works

The R2R3‐MYB‐SG7 transcription factor CaMYB39 orchestrates surface phenylpropanoid metabolism and pathogen resistance in chickpea

Saxena, S., Pal, L., Naik, J., Singh, Y., Verma, P. K., Chattopadhyay, D., & Pandey, A. K. (2023) · New Phytologist · doi:10.1111/nph.18758 · Cited by 48 · see citing works

Therapeutic effects and molecular mechanisms of quercetin in gynecological disorders

Jian, X., Chen, S., Luo, W., Zhou, L., Jiang, L., & Liu, K. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116418 · Cited by 48 · see citing works

Enhancing the Efficacy of Active Pharmaceutical Ingredients in Medicinal Plants through Nanoformulations: A Promising Field

Chen, Y., Tang, Y., Li, Y., Rui, Y., & Zhang, P. (2024) · Nanomaterials · doi:10.3390/nano14191598 · Cited by 48 · see citing works

Apigenin in cancer therapy: From mechanism of action to nano-therapeutic agent.

Zhou, Y., Yu, Y.-J., Lv, H., Zhang, H., Liang, T., Zhou, G.-E., Huang, L.-P., Tian, Y., & Liang, W. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113385 · Cited by 39 · see citing works

Application of Polyphenols and Flavonoids in Oncological Therapy

Roszkowski, S. (2023) · Molecules · doi:10.3390/molecules28104080 · Cited by 46 · see citing works

Natural Alkaloids in Cancer Therapy: Berberine, Sanguinarine and Chelerythrine against Colorectal and Gastric Cancer

Duda-Madej, A., Viscardi, S., Szewczyk, W., & Topola, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158375 · Cited by 46 · see citing works

Mechanisms of Action of Fruit and Vegetable Phytochemicals in Colorectal Cancer Prevention

Yepes, T. A., Pérez-Palacio, L., Martínez, E., & Osorio, M. (2023) · Molecules · doi:10.3390/molecules28114322 · Cited by 45 · see citing works

Metal–Phenolic Networks for Chronic Wounds Therapy

Wang, D., Xing, J., Zhang, Y., Guo, Z., Deng, S., Guan, Z., He, B., Ma, R., Leng, X., Dong, K., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s434535 · Cited by 45 · see citing works

Co-Delivery of Curcumin and Quercetin in Shellac Nanocapsules for the Synergistic Antioxidant Properties and Cytotoxicity Against Colon Cancer Cells

Jain, S., Lenaghan, S. C., Día, V. P., & Zhong, Q. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136744 · Cited by 44 · see citing works

Application of Luteolin in Neoplasms and Nonneoplastic Diseases

Rakoczy, K., Kaczor, J., Sołtyk, A., Szymańska, N., Stecko, J., Sleziak, J., Kulbacka, J., & Baczyńska, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115995 · Cited by 44 · see citing works

Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential

Kurkiewicz, M., Moździerz, A., Rzepecka‐Stojko, A., & Stojko, J. (2025) · Pharmaceuticals · doi:10.3390/ph18081162 · Cited by 44 · see citing works

Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review

Cecerska‐Heryć, E., Wiśniewska, Z., Serwin, N. M., Polikowska, A., Goszka, M., Engwert, W., Michałów, J., Pękała, M., Budkowska, M., Michalczyk, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084505 · Cited by 43 · see citing works

Therapeutic effect of targeted antioxidant natural products

Mukherjee, S., Chopra, H., Goyal, R., Jin, S., Dong, Z., Das, T., & Bhattacharya, T. (2024) · Discover Nano · doi:10.1186/s11671-024-04100-x · Cited by 43 · see citing works

Diet‐derived ergothioneine induces necroptosis in colorectal cancer cells by activating the SIRT3/MLKL pathway

D’Onofrio, N., Martino, E., Balestrieri, A., Mele, L. L., Cautela, D., Castaldo, D., & Balestrieri, M. L. (2022) · FEBS Letters · doi:10.1002/1873-3468.14310 · Cited by 45 · see citing works

Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics

Pandey, P., Khan, F., Seifeldin, S., Alshaghdali, K., Siddiqui, S., Abdelwadoud, M. E., Vyas, M., Saeed, M., Mazumder, A., & Saeed, A. (2023) · Nutrients · doi:10.3390/nu15092088 · Cited by 43 · see citing works

Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment

Kowalski, S., Karska, J., Tota, M., Skinderowicz, K., Kulbacka, J., & Drąg‐Zalesińska, M. (2024) · Molecules · doi:10.3390/molecules29030728 · Cited by 41 · see citing works

Advancements in redox-sensitive micelles as nanotheranostics: A new horizon in cancer management

Sikder, A., Vambhurkar, G. B., Amulya, E., Bagasariya, D., Famta, P., Shah, S., Khatri, D. K., Singh, S. B., Sinha, V. R., & Srivastava, S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.008 · Cited by 41 · see citing works

C. spinosa L. subsp. rupestris Phytochemical Profile and Effect on Oxidative Stress in Normal and Cancer Cells

Bacchetti, T., Campagna, R., Sartini, D., Cecati, M., Morresi, C., Bellachioma, L., Martinelli, E., Rocchetti, G., Lucini, L., Ferretti, G., et al. (2022) · Molecules · doi:10.3390/molecules27196488 · Cited by 40 · see citing works

Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties

Mesmar, J. E., Abdallah, R., Badran, A., Maresca, M., Shaito, A. A., & Baydoun, E. (2022) · Molecules · doi:10.3390/molecules27134240 · Cited by 40 · see citing works

Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway

Li, Y., He, B., Zhang, C., He, Y., Xia, T., & Zeng, C. (2023) · Nutrients · doi:10.3390/nu15061340 · Cited by 38 · see citing works

Molecular characterization of a flavanone 3-hydroxylase gene from citrus fruit reveals its crucial roles in anthocyanin accumulation

Ma, G., Zhang, L., Yamamoto, R., Kojima, N., Yahata, M., & Kato, M. (2023) · BMC Plant Biology · doi:10.1186/s12870-023-04173-3 · Cited by 38 · see citing works

Current insights and future perspectives of flavonoids: A promising antihypertensive approach

Harahap, U., Syahputra, R. A., Ahmed, A., Nasution, A., Wisely, W., Sirait, M. L., Dalimunthe, A., Zainalabidin, S., Taslim, N. A., Nurkolis, F., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8199 · Cited by 38 · see citing works

Naringenin Induces HepG2 Cell Apoptosis via ROS-Mediated JAK-2/STAT-3 Signaling Pathways

Zhang, M., Lai, J., Wu, Q., Lai, J., Su, J., Zhu, B., & Li, Y. (2023) · Molecules · doi:10.3390/molecules28114506 · Cited by 36 · see citing works

WPI-coated liposomes as a delivery vehicle for enhancing the thermal stability and antioxidant activity of luteolin

Huang, M., Lu, H., Ahmad, M., & Ying, R. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.137786 · Cited by 36 · see citing works

The Role of Selected Flavonoids in Modulating Neuroinflammation in Alzheimer’s Disease: Mechanisms and Therapeutic Potential

Kruszka, J., Martyński, J., Szewczyk‐Golec, K., Woźniak, A., & Nuszkiewicz, J. (2025) · Brain Sciences · doi:10.3390/brainsci15050485 · Cited by 35 · see citing works

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Calvo, M. M., Martín‐Diana, A. B., Rico, D., López-Caballero, M. E., & Martínez‐Álvarez, Ó. (2022) · Foods · doi:10.3390/foods11111581 · Cited by 35 · see citing works

The role of the natural compound naringenin in AMPK-mitochondria modulation and colorectal cancer inhibition

Wang, D., Zhou, Y., Hua, L., Hu, M., Zhu, N., Liu, Y., & Zhou, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155786 · Cited by 34 · see citing works

Synergism Potentiates Oxidative Antiproliferative Effects of Naringenin and Quercetin in MCF-7 Breast Cancer Cells

Rhman, M. A., Devnarain, N., Khan, R. B., & Owira, P. M. O. (2022) · Nutrients · doi:10.3390/nu14163437 · Cited by 34 · see citing works

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Daneshvar, S., Zamanian, M. Y., Ivraghi, M. S., Golmohammadi, M., Modanloo, M., Kamiab, Z., Pourhosseini, S. M. E., Heidari, M., & Bazmandegan, G. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3645 · Cited by 33 · see citing works

Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope

Gupta, M., Ahmad, J., Ahamad, J., Kundu, S., Goel, A., & Mishra, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7975 · Cited by 35 · see citing works

Electrochemistry of lyophilized blueberry and raspberry samples: ROS activation of the antioxidant ability of anthocyanins

Domínguez, I., Romero, I., Sánchez-Ballesta, M. T., Escribano, M. I., Merodio, C., & Doménech‐Carbó, A. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.137649 · Cited by 33 · see citing works

Multi-therapeutic potential of flavonoids as an essential component in nutraceuticals for the treatment and management of human diseases

Okoduwa, S. I. R., Abdulwaliyu, I., Igiri, B. E., Arekemase, S. O., Okoduwa, U. J., Itiat, J. F., Egbule, M. N., & Mustapha, R. A. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100558 · Cited by 32 · see citing works

Effects of Green Tea Extract Epigallocatechin-3-Gallate on Oral Diseases: A Narrative Review

Li, Y., Cheng, L., & Li, M. (2024) · Pathogens · doi:10.3390/pathogens13080634 · Cited by 36 · see citing works

Protective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies

Wójciak, M., Drozdowski, P., Skalska-Kamińska, A., Zagórska-Dziok, M., Ziemlewska, A., Nizioł‐Łukaszewska, Z., & Latalska, M. (2024) · Molecules · doi:10.3390/molecules29235790 · Cited by 32 · see citing works

Exploiting Polyphenol-Mediated Redox Reorientation in Cancer Therapy

Li, L., Jin, P., Guan, Y., Luo, M., Wang, Y., He, B., Li, B., He, K., Cao, J., Huang, C., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15121540 · Cited by 31 · see citing works

Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS-mediated signaling pathways

Liu, J., Li, S., Yan-jun, T., Cao, J., Hou, W.-S., Wang, A., Wang, C., & Jin, C. (2024) · Redox Report · doi:10.1080/13510002.2024.2313366 · Cited by 31 · see citing works

Effects of apigenin on gastric cancer cells

Pratas, A., Malhão, B., Palma, R., Mendonça, P., Cervantes, R., & Marques-Ramos, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116251 · Cited by 31 · see citing works

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

Bag, S., Burman, M. D., & Bhowmik, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13959 · Cited by 31 · see citing works

Luteolin alleviates airway remodeling in asthma by inhibiting the epithelial-mesenchymal transition via β-catenin regulation

Quan, J., Xie, D., Li, Z., Yu, X., Liang, Z., Chen, Y., Wu, L., Huang, D., Lin, L., & Fan, L. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156090 · Cited by 32 · see citing works

Multifunctional iron-apigenin nanocomplex conducting photothermal therapy and triggering augmented immune response for triple negative breast cancer

Chen, R., Jiang, Z., Cheng, Y., Ye, J., Li, S., Xu, Y., Ye, Z., Shi, Y., Ding, J., Zhao, Y., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124016 · Cited by 29 · see citing works

Natural protection against oxidative stress in human skin melanocytes

Mucha, M., Skrzydlewska, E., & Gęgotek, A. (2025) · Communications Biology · doi:10.1038/s42003-025-08725-1 · Cited by 36 · see citing works

Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin

Rauf, A., Abu‐Izneid, T., Imran, M., Hemeg, H. A., Bashir, K., Aljohani, A. S. M., Aljohani, M. S. M., Alhumaydhi, F. A., Khan, I. N., Emran, T. B., et al. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230710162217 · Cited by 29 · see citing works

Analysis of proanthocyanidins and flavonols in the seedpods of Chinese Antique Lotus: A rich source of antioxidants

Wang, X., Li, B., Sun, S., Liu, Q., Zhu, J., Zhu, J., Zhang, H., Wu, Q., & Wang, L. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135756 · Cited by 28 · see citing works

A Review on Anticancer Profile of Flavonoids: Sources, Chemistry, Mechanisms, Structure-activity Relationship and Anticancer Activity

Nayak, S. K., Shah, S., Narang, R., Singh, V. J., & Govindaiah, P. (2023) · Current Drug Research Reviews · doi:10.2174/2589977515666230120144852 · Cited by 28 · see citing works

Critical Review in Designing Plant-Based Anticancer Nanoparticles against Hepatocellular Carcinoma

Basu, A., Namporn, T., & Ruenraroengsak, P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061611 · Cited by 27 · see citing works

Alleviation of cadmium toxicity in pea (Pisum sativum L.) through Zn−Lys supplementation and its effects on growth and antioxidant defense

Saleem, M. H., Parveen, A., Perveen, S., Akhtar, N., Abasi, F., Ehsan, M., Ali, H., Okla, M. K., Saleh, I. A. S., Zomot, N., et al. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-31874-5 · Cited by 27 · see citing works

Integrative Analysis of Metabolome and Transcriptome Reveals Molecular Insight into Metabolomic Variations during Hawthorn Fruit Development

Wang, Y., Hao, R., Guo, R., Nong, H., Qin, Y., & Dong, N. (2023) · Metabolites · doi:10.3390/metabo13030423 · Cited by 26 · see citing works

Role of Flavonoids in Modulation of Mitochondria Dynamics during Oxidative Stress

Kumar, S., Chhabra, V., Shenoy, S., Daksh, R., Ravichandiran, V., Swamy, R. S., & Kumar, N. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575259219230920093214 · Cited by 28 · see citing works

Current situation, trend, and prospects of research on functional components from by-products of baijiu production: A review

Jiang, Y., Sun, J., Chandrapala, J., Majzoobi, M., Brennan, C. S., Zeng, X., & Sun, B. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114032 · Cited by 24 · see citing works

A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid

Singh, B., & Semwal, B. C. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266316032240718050055 · Cited by 24 · see citing works

Layer by layer self-assembled hyaluronic acid nanoarmor for the treatment of ulcerative colitis

Zhao, X., Zhang, Y.-C., Wang, P., Liu, K.-L., Zheng, Y.-H., Wen, J.-P., Wang, K., & Wen, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02933-3 · Cited by 19 · see citing works

Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway

Shan, H., Zhang, X., Mi, Y., Jia, J., Wang, B., & Yang, Q. (2022) · Pharmaceuticals · doi:10.3390/ph15121477 · Cited by 24 · see citing works

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis

Ye, Y., Yang, L., Leng, M., Wang, Q., Wu, J., Wan, W., Wang, H., Li, L., Peng, Y., Chai, S., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1255069 · Cited by 24 · see citing works

Natural products modulating MAPK for CRC treatment: a promising strategy

Zhou, L., Zhang, J., Zhao, K., Chen, B., & Sun, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1514486 · Cited by 23 · see citing works

Green Tea: Antioxidant vs. Pro-Oxidant Activity

Stoeva, S., Hvarchanova, N., Georgiev, K., & Radeva-Ilieva, M. P. (2025) · Beverages · doi:10.3390/beverages11030064 · Cited by 22 · see citing works

Flavonoids as receptor tyrosine kinase inhibitors in lung cancer

Dev, S. S., Farghadani, R., Abidin, S. A. Z., Othman, I., & Naidu, R. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105845 · Cited by 22 · see citing works

20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells

Shuvalov, O., Kirdeeva, Y., Fefilova, E., Netsvetay, S., Zorin, M., Vlasova, Y., Fedorova, O., Daks, A., Parfenyev, S., & Barlev, N. (2023) · Metabolites · doi:10.3390/metabo13050656 · Cited by 21 · see citing works

Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties

Mesmar, J. E., Abdallah, R., Hamade, K., Baydoun, S. E., Al‐Thani, N. A., Shaito, A. A., Maresca, M., Badran, A., & Baydoun, E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.994025 · Cited by 21 · see citing works

Characterization and anti-aging effects of Opuntia ficus-indica (L.) Miller extracts in a d -galactose-induced skin aging model

Abbas, E. Y., Ezzat, M. I., Ramadan, N. M., Eladl, A., Hamed, W. H. E., Abdel‐Aziz, M. M., Teaima, M. H. M., El-Hefnawy, H. M., & Abdel-Sattar, E. A. (2023) · Food & Function · doi:10.1039/d2fo03834j · Cited by 21 · see citing works

Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases

Yi, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210402 · Cited by 21 · see citing works

TRAIL-Sensitizing Effects of Flavonoids in Cancer

Luiz-Ferreira, Â., Pacifico, T., Cruz, Á. C., Laudisi, F., Monteleone, G., & Stolfi, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316596 · Cited by 21 · see citing works

Ziziphus mauritiana Lam. Bark and Leaves: Extraction, Phytochemical Composition, In Vitro Bioassays and In Silico Studies

Nilofar, N., Sinan, K. I., Dall’Acqua, S., Sut, S., Uba, A. İ., Etienne, O. K., Ferrante, C., Ahmad, J., & Zengin, G. (2024) · Plants · doi:10.3390/plants13162195 · Cited by 21 · see citing works

Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)

Ding, Y., & Yu, Y. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13474 · Cited by 20 · see citing works

Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders

Kamboj, N., Sharma, S., & Kumar, R. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.100673 · Cited by 20 · see citing works

Bovine hemoglobin thermal stability in the presence of naringenin: Calorimetric, spectroscopic and molecular modeling studies

Precupaş, A., Leontieş, A. R., Neacșu, A., Angelescu, D. G., & Popa, V. T. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.119617 · Cited by 20 · see citing works

Correlation of the anticancer and pro-oxidant behavior and the structure of flavonoid-oxidovanadium(IV) complexes

Naso, L. G., Ferrer, E. G., & Williams, P. A. M. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215271 · Cited by 20 · see citing works

Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas

Baba, R. A., Mir, H. A., Mokhdomi, T. A., Bhat, H. F., Ahmad, A., & Khanday, F. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1318797 · Cited by 20 · see citing works

Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer

Bai, Y., Liang, C., Zhou, J., Liu, Y., Wang, F., Gao, J., Wu, J. F., & Hu, D. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115656 · Cited by 19 · see citing works

Moringa oleifera: A Review on the Antiproliferative Potential in Breast Cancer Cells

Moremane, M. M., Abrahams, B., & Tiloke, C. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45080434 · Cited by 19 · see citing works

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang, Y., & Xie, J. (2024) · Phytotherapy Research · doi:10.1002/ptr.8149 · Cited by 19 · see citing works

Durability improvement for ePTFE reinforced perfluorosulfonic acid membranes by natural organic free radical scavengers

Li, X., Chen, X., Guo, X., Fang, J., Li, H., & Wang, B. (2024) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2024.02.359 · Cited by 19 · see citing works

Modulation of the c-JNK/p38-MAPK signaling pathway: Investigating the therapeutic potential of natural products in hypertension

Sahu, R., & Rawal, R. K. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100564 · Cited by 19 · see citing works

Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach

Safe, S. H. (2024) · Exploration of Drug Science · doi:10.37349/eds.2024.00054 · Cited by 19 · see citing works

Psychopharmacology case studies

Wilson, W. H. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90078-5

Flavonoids and Their Anticancer Properties

Singh, S., Saini, D., Devi, D., & Sharma, K. K. (2023) · Apple Academic Press eBooks · doi:10.1201/9781003369813-9

Anticancer Activity of Flavonoids

Azad, A. K., Dayoob, M., & Zohera, F. T. (2024) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-1646-7.ch001 · Cited by 2 · see citing works

Current Trends and Prospective Role of Flavonoids and Flavones as Anticancer Agents: A Review

Sharma, R., Sapra, K., Samamadar, S., Sapra, A., & Kumar, V. (2023) · Current Nutrition & Food Science · doi:10.2174/1573401319666230213103617 · Cited by 5 · see citing works

Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy

Lee, Y.-K., Lee, J., & Lim, C. (2021) · Food Science and Biotechnology · doi:10.1007/s10068-021-00899-8 · Cited by 30 · see citing works