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Structure of the pheromone peptide of the Staphylococcus epidermidis agr system
Abstract
The agr quorum‐sensing system is responsible for the regulation of several virulence factors in staphylococci, with an extracellular pheromone peptide as signalling molecule. By monitoring the biological activity of synthetic peptides, it could be demonstrated that the pheromone of the agr system in Staphylococcus epidermidis is an octapeptide containing a thiolester linkage between the central cysteine and the C‐terminal carboxyl group. The peptide was active at nanomolar concentrations. The N‐terminus of the peptide pheromone, which is encoded as part of a protein precursor, proved to be crucial for biological activity.
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Cited by
Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20085f · Cited by 2,076
Coagulase-Negative Staphylococci
Becker, K., Heilmann, C., & Peters, G. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00109-13 · Cited by 1,628
Staphylococcus epidermidis infections
Vuong, C., & Otto, M. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01563-0 · Cited by 708
Self-citationQuorum sensing in bacterial virulence
Antunes, L. C. M., Ferreira, R. B. R., Buckner, M. M. C., & Finlay, B. B. (2010) · Microbiology · doi:10.1099/mic.0.038794-0 · Cited by 537
Impact of the agr Quorum‐Sensing System on Adherence to Polystyrene in Staphylococcus aureus
Vuong, C., Saenz, H. L., Götz, F., & Otto, M. (2000) · The Journal of Infectious Diseases · doi:10.1086/317606 · Cited by 499
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Metadata
- Authors
- Otto, M., Süßmuth, R., Jung, G., & Götz, F.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-03-06
- Volume
- 424
- Issue
- 1-2
- Pages
- 89-94
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2155491300
- Cited by
- 159
- References
- 0
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Otto, M., Süßmuth, R., Jung, G., & Götz, F. (1998). Structure of the pheromone peptide of the Staphylococcus epidermidis agr system. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)00145-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
