The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased flux of free radicals in cells subjected to hyperthermia: detection by electron paramagnetic resonance spin trapping
Abstract
It has been hypothesized that hyperthermia promotes oxygen‐centered free radical formation in cells; however, to date there is no direct evidence of this heat‐induced increase in oxygen free radical flux. Using electron paramagnetic resonance (EPR) spin trapping, we sought direct evidence for free radical generation during hyperthermia in intact, functioning cells. Rat intestinal epithelial cell monolayers were exposed to 45°C for 20 min, after which the nitrone spin trap 5,5‐dimethyl‐1‐pyrroline N‐oxide (DMPO) was added. Compared to control cells at 37°C, heat‐exposed cells had increased free radical EPR signals, consistent with the formation of DMPO/⋅OH (a N=a H=14.9 G). These findings indicate that heat increases the flux of cellular free radicals and support the hypothesis that increased generation of oxygen‐centered free radicals and the resultant oxidative stress may mediate in part, heat‐induced cellular damage.
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Cites
Temperature, skeletal muscle mitochondrial functions, and oxygen debt
Brooks, G., Hittelman, K., Faulkner, J., & Beyer, R. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.220.4.1053 · Cited by 261
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A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer
Jung, H. S., Lee, J.-H., Kim, K., Koo, S., Verwilst, P., Sessler, J. L., Kang, C., & Kim, J. S. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b04263 · Cited by 371
Lambert, G. P., Gisolfi, C. V., Berg, D. J., Moseley, P. L., Oberley, L. W., & Kregel, K. C. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00787.2001 · Cited by 326
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Metadata
- Authors
- Flanagan, S. W., Moseley, P. L., & Buettner, G. R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-07-17
- Volume
- 431
- Issue
- 2
- Pages
- 285-286
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2115362310
- Cited by
- 217
- References
- 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Flanagan, S. W., Moseley, P. L., & Buettner, G. R. (1998). Increased flux of free radicals in cells subjected to hyperthermia: detection by electron paramagnetic resonance spin trapping. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)00779-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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