The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer
Open accessAbstract
Cryptocyanine-based probes exhibit highly efficient photothermal conversion and represent a new class of photothermal agents for use in photothermal therapy (PTT). With the thermal susceptibility of mitochondria in mind, we have prepared a mitochondria-targeted, NIR-absorbing cryptocyanine probe ( Mito-CCy ) and evaluated its photophysical properties, photothermal conversion efficiency, biological compatibility, cytotoxicity, and mitochondrial localization in HeLa cells. Upon subjecting 0.5 mL of a PBS buffer solution (10 mM, pH 7.4, containing 50% DMSO) of Mito-CCy (0.5 mM) to 730 nm laser irradiation at 2.3 W/cm 2, the temperature of the solution increased by 13.5 °C within 5 min. In contrast, the corresponding cryptocyanine ( CCy ) lacking the triarylphosphonium group gave rise to only an ∼3.4 °C increase in solution temperature under otherwise identical conditions. Mito-CCy also exhibited high cytotoxicity in HeLa cells when subject to photoirradiation. This light-induced cytotoxicity is attributed to the endogenous production of reactive oxygen species (ROS) induced under conditions of local heating. ROS are known to interfere with the mitochondrial defense system and to trigger apoptosis. By targeting the mitochondria, the present sensitizer-based photothermogenic approach is rendered more effective. As such, the system reported here represents the vanguard of what might be a new generation of organelle-targeted photothermal therapeutics.
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Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery
Li, H., Kim, D., Yao, Q., Ge, H., Chung, J., Fan, J., Wang, J., Peng, X., & Yoon, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009796 · Cited by 363
Metadata
- Authors
- Jung, H. S., Lee, J.-H., Kim, K., Koo, S., Verwilst, P., Sessler, J. L., Kang, C., & Kim, J. S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-07-11
- Volume
- 139
- Issue
- 29
- Pages
- 9972-9978
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2684723911
- Cited by
- 371
- References
- 45
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- green
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