The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Nitrite reductase activity is a novel function of mammalian mitochondria
Open accessAbstract
Nitrite, which is the major stable degradation product of nitric oxide, exists in all tissues capable of nitric oxide synthesis from L‐arginine. The present study provides experimental evidence that nitrite in contact with respiring mitochondria accepts reducing equivalents from the ubiquinone cycle of the respiratory chain. Univalent reduction of nitrite was totally inhibited by myxothiazol. We therefore conclude on the involvement of redox cycling that ubisemiquinone is associated with the bc 1 complex. Recycling of nitric oxide degradation products via these electron carriers may become a threat to energy‐linked respiration since nitric oxide in direct contact with mitochondria was shown to slow the energy‐linked respiration down and to trigger a mitochondrial source for superoxide radicals. Until now, the existence of nitrite reductase activity was only demonstrated in plants and bacteria. In addition, the present observation elucidates the existence of a nitric oxide synthase‐independent nitric oxide source.
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“In situations of hypoxia, when the oxygen-dependent NO synthases may become dysfunctional, nitrite reduction is instead greatly enhanced.”
From Nitrate and nitrite in biology, nutrition and therapeutics (2009) · cites this paper as [9]
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“Sruti Shiva (University of Pittsburgh) reviewed a number of studies demonstrating that components of the respiratory chain can reduce nitrite to NO (refs. 4,9)”
From Nitrate and nitrite in biology, nutrition and therapeutics (2009) · cites this paper as [9]
In the citing paper
“This was later confirmed by Kozlov’s group who illustrated that cytochrome c oxidase was an important regulator of nitrite reduction to NO in the mitochondria [120, 121].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [120]
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Gasotransmission of Nitric Oxide (NO) at Early Plant Developmental Stages
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“Reduction of nitrite to NO by mitochondrial electron transport has also been reported for green algae (Tischner et al. 2004) and animals ( Kozlov et al. 1999 ).”
BackgroundNitric oxide functions in the heart
Kıvrak, T., Erdem, K., & Karaca, I. (2017) · Archives of Anatomy and Physiology · doi:10.17352/aap.000007 · Cited by 1
“Many proteins are known to be contained in the NO metabolite cycle and nitrite’s reduction to NO, including xanthine oxidase [12,13], deoxyhemoglobin and deoxymyoglobin [14–16], neuroglobin [17], respiratory chain enzymes [18], cytochrome P450 [19], aldehyde oxidase [20], carbonic anhydrase (21) and NO synthase [22,23…”
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“Reduction of NO2- to NO is also possible in mitochondria of plants and animals in the presence of NADH (Kozlov et al., 1999; Stoimenova et al., 2007).”
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Metadata
- Authors
- Kozlov, A. V., Staniek, K., & Nohl, H.
- Affiliations
- University of Veterinary Medicine Vienna (AT)
- Corresponding author
- Nohl, Hans
- ORCID
- Kozlov, Andrey V
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-07-02
- Volume
- 454
- Issue
- 1-2
- Pages
- 127-130
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2149980494
- Cited by
- 342
- References
- 14
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 9 · 2019: 15 · 2018: 11 · 2017: 16 · 2016: 14 · 2015: 22 · 2014: 15 · 2013: 9 · 2012: 17
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- nitrite reductase, mitochondria, nitric oxide degradation, nitrite, bc1 complex, ubisemiquinone, myxothiazol, redox cycling, superoxide, electron transport chain
- MeSH terms
- Animals, Electron Spin Resonance Spectroscopy, Electron Transport, Liver, Mitochondria, Models, Biological, Nitric Oxide, Nitrite Reductases, Cell Respiration, Rats
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