The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells
Abstract
Variable number tandem repeats (VNTR) within non‐coding regions of a number of genes have been correlated with susceptibility to various disease states. In particular, a VNTR polymorphism of a 16 or 17 bp element within intron 2 of the human serotonin transporter gene has been correlated with a predisposition to affective disorders. We have demonstrated that this region will support differential levels of reporter gene expression in differentiating embryonic stem cells, this being dependent on the presence of 10 or 12 copies of the repeat. The VNTR domain can therefore act as a transcriptional regulator, a property which potentially contributes to disease susceptibility.
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Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809
Gill, M., Daly, G., Heron, S., Hawi, Z., & Fitzgerald, M. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000290 · Cited by 482
Cited by
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020
Hranilovic, D., Stefulj, J., Schwab, S., Borrmann-Hassenbach, M., Albus, M., Jernej, B., & Wildenauer, D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.029 · Cited by 224
Treutlein, J., Kissling, C., Frank, J., Wiemann, S., Dong, L., Depner, M., Saam, C., Lascorz, J., Soyka, M., Preuss, U. W., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001813 · Cited by 186
Genetic variants implicated in personality: A review of the more promising candidates
Savitz, J. B., & Ramesar, R. S. (2004) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20155 · Cited by 114
Mood changes after delivery: role of the serotonin transporter gene
Sanjuan, J., Martin-Santos, R., Garcia-Esteve, L., Carot, J. M., Guillamat, R., Gutierrez-Zotes, A., Gornemann, I., Canellas, F., Baca-Garcia, E., Jover, M., et al. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.045427 · Cited by 109
Metadata
- Authors
- Fiskerstrand, C. E., Lovejoy, E. A., & Quinn, J. P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-09-10
- Volume
- 458
- Issue
- 2
- Pages
- 171-174
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2086414140
- Cited by
- 256
- References
- 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. https://app.cochat.ai/papers/10.1016/s0014-5793(99)01150-3
- The paper
- Fiskerstrand, C. E., Lovejoy, E. A., & Quinn, J. P. (1999). An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Letters. https://doi.org/10.1016/s0014-5793(99)01150-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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