The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
GDNF triggers a novel Ret‐independent Src kinase family‐coupled signaling via a GPI‐linked GDNF receptor α1
Abstract
Glial cell line‐derived neurotrophic factor (GDNF) has potentially great clinical importance in the treatment of Parkinson's disease and several other neurodegenerative diseases, however its intracellular signaling mechanisms are poorly understood. Here we show that upon GDNF binding glycosyl‐phosphatidylinositol (GPI)‐linked GDNF receptor α1 (GFRα1) activates cytoplasmic Src family tyrosine kinase(s) in Ret tyrosine kinase‐deficient cultured mouse dorsal root ganglion neurons and in two Ret‐negative cell lines. GFRα1‐mediated Src‐type kinase activation subsequently triggers phosphorylation of mitogen‐activated protein kinase, cAMP response element binding protein and phospholipase Cγ. We therefore conclude that GDNF can activate intracellular signaling pathways Ret‐independently via GPI‐linked GFRα1.
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Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Cited by
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Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Novel functions and signalling pathways for GDNF
Sariola, H., & Saarma, M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00786 · Cited by 648
Self-citationThe Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands
Paratcha, G., Ledda, F., & Ibáñez, C. F. (2003) · Cell · doi:10.1016/s0092-8674(03)00435-5 · Cited by 623
RET tyrosine kinase signaling in development and cancer
Arighi, E., Borrello, M. G., & Sariola, H. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.05.010 · Cited by 468
Lipid rafts in neuronal signaling and function
Tsui-Pierchala, B. A., Encinas, M., Milbrandt, J., & Johnson, E. M. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02215-4 · Cited by 409
Metadata
- Authors
- Poteryaev, D., Titievsky, A., Sun, Y. F., Thomas-Crusells, J., Lindahl, M., Billaud, M., Arumäe, U., & Saarma, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-12-07
- Volume
- 463
- Issue
- 1-2
- Pages
- 63-66
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2084641355
- Cited by
- 173
- References
- 1
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Poteryaev, D., Titievsky, A., Sun, Y. F., Thomas-Crusells, J., Lindahl, M., Billaud, M., Arumäe, U., & Saarma, M. (1999). GDNF triggers a novel Ret‐independent Src kinase family‐coupled signaling via a GPI‐linked GDNF receptor α1. FEBS Letters. https://doi.org/10.1016/s0014-5793(99)01590-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
