Cited by 170Reproductive Health and ContraceptionOvarian function and disordersHypothalamic control of reproductive hormones

Use of the novel combined contraceptive vaginal ring NuvaRing for ovulation inhibition

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Mulders, Titia M.T, Dieben, Thom O.M·2001·Fertility and Sterility

Abstract

Objective To assess the effects of the combined contraceptive vaginal ring NuvaRing on ovarian function.Design Randomized, open-label, crossover study.Setting Clinical pharmacology unit.Participant(s) Sixteen healthy female volunteers.Intervention(s) Group 1: one cycle of combined oral contraceptive containing desogestrel (150 microg) and ethinyl estradiol (30 microg) (desogestrel/EE COC), followed by a NuvaRing treatment period. Group 2: NuvaRing treatment period followed by a cycle of desogestrel/EE COC.Main outcome measure(s) Follicular diameter, serum hormone concentrations (follicle-stimulating hormone, 17beta estradiol, luteinizing hormone, and progesterone), and endometrial thickness.Result(s) NuvaRing use for the recommended period of 3 weeks resulted in complete inhibition of ovulation, as assessed by vaginal ultrasound (follicular diameter) and by serum luteinizing hormone and progesterone concentrations. Inhibition of ovulation was maintained for an additional 2 weeks of NuvaRing use. Ovarian suppression between the groups was comparable. Furthermore, ovarian suppression after 3 weeks of NuvaRing use was comparable to that on day 21 of DGS/EE COC intake. NuvaRing was well tolerated.Conclusion(s) NuvaRing completely inhibited ovulation throughout the normal 3-week period and the extended period of use. Ovarian suppression was comparable to that with desogestrel/EE COC.

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Crossref · 10.1016/s0015-0282(01)01689-2

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Authors
Mulders, T. M. T., & Dieben, T. O. M.
Affiliations
Organon (Netherlands) (NL)
Corresponding author
Dieben, Thom O.M
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2001-05
Volume
75
Issue
5
Pages
865-870
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2158600879
Cited by
170
References
5
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 7
FWCI
15.77
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
NuvaRing, vaginal ring, combined oral contraceptives, ovulation inhibition, ovarian suppression, desogestrel, ethinyl estradiol, follicle-stimulating hormone, luteinizing hormone, follicle size, endometrial thickness
MeSH terms
Adolescent, Adult, Contraceptive Devices, Female, Contraceptives, Oral, Synthetic, Endometrium, Ethinyl Estradiol, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Luteinizing Hormone, Ovulation, Progesterone, Time Factors, Ultrasonography, Vinyl Compounds, Desogestrel, Cross-Over Studies, Estradiol Congeners

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