Use of the novel combined contraceptive vaginal ring NuvaRing for ovulation inhibition
Open accessAbstract
Objective To assess the effects of the combined contraceptive vaginal ring NuvaRing on ovarian function.Design Randomized, open-label, crossover study.Setting Clinical pharmacology unit.Participant(s) Sixteen healthy female volunteers.Intervention(s) Group 1: one cycle of combined oral contraceptive containing desogestrel (150 microg) and ethinyl estradiol (30 microg) (desogestrel/EE COC), followed by a NuvaRing treatment period. Group 2: NuvaRing treatment period followed by a cycle of desogestrel/EE COC.Main outcome measure(s) Follicular diameter, serum hormone concentrations (follicle-stimulating hormone, 17beta estradiol, luteinizing hormone, and progesterone), and endometrial thickness.Result(s) NuvaRing use for the recommended period of 3 weeks resulted in complete inhibition of ovulation, as assessed by vaginal ultrasound (follicular diameter) and by serum luteinizing hormone and progesterone concentrations. Inhibition of ovulation was maintained for an additional 2 weeks of NuvaRing use. Ovarian suppression between the groups was comparable. Furthermore, ovarian suppression after 3 weeks of NuvaRing use was comparable to that on day 21 of DGS/EE COC intake. NuvaRing was well tolerated.Conclusion(s) NuvaRing completely inhibited ovulation throughout the normal 3-week period and the extended period of use. Ovarian suppression was comparable to that with desogestrel/EE COC.
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Two major changes were made to the original Harris Clark 2003 and Margolskee 2011 models to simulate contraceptive behavior that is consistent with the biology.
“Made two major changes to the original models (Harris Clark 2003 and Margolskee 2011) to simulate contraceptive behavior that is consistent with the biology.”
From A Survey of Mathematical Modeling of Hormonal Contraception and the Menstrual Cycle (2024) · cites this paper as [10]
In a new model, P_app limits early follicle development and is enhanced by E2.
“In this new model, . P app limits early follicle development and is enhanced by E . 2”
From A Survey of Mathematical Modeling of Hormonal Contraception and the Menstrual Cycle (2024) · cites this paper as [10]
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Hormonal contraception: recent advances and controversies
(2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.08.012 · Cited by 8 · see citing works
Nondaily Contraceptive Options
Kottke, M., & Cwiak, C. A. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e318181a7d9 · Cited by 8 · see citing works
Vaginal delivery of contraceptives
Sitruk-Ware, R. L. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.4.729 · Cited by 8 · see citing works
Nave, R., Jalkanen, T., Talling, C., Kaneko, M., Matsuki, S., & Höchel, J. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.11.009 · Cited by 7 · see citing works
Novedades en anticoncepción hormonal
de Castro, F. L., & Prieto, J. L. (2005) · Información terapéutica del Sistema Nacional de Salud · Cited by 7 · see citing works
- Authors
- Mulders, T. M. T., & Dieben, T. O. M.
- Affiliations
- Organon (Netherlands) (NL)
- Corresponding author
- Dieben, Thom O.M
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 75
- Issue
- 5
- Pages
- 865-870
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2158600879
- Cited by
- 170
- References
- 5
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- NuvaRing, vaginal ring, combined oral contraceptives, ovulation inhibition, ovarian suppression, desogestrel, ethinyl estradiol, follicle-stimulating hormone, luteinizing hormone, follicle size, endometrial thickness
- MeSH terms
- Adolescent, Adult, Contraceptive Devices, Female, Contraceptives, Oral, Synthetic, Endometrium, Ethinyl Estradiol, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Luteinizing Hormone, Ovulation, Progesterone, Time Factors, Ultrasonography, Vinyl Compounds, Desogestrel, Cross-Over Studies, Estradiol Congeners
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