Sperm morphology as diagnosed by strict criteria: probing the impact of teratozoospermia on fertilization rate and pregnancy outcome in a large in vitro fertilization population
Open accessAbstract
Objective To investigate the predictive value of sperm morphology assessed by strict criteria on IVF outcome. Design Retrospective analysis of all IVF cycles (January 1987 to December 1992). Main outcome measures All patients were assigned to one of three groups based on sperm morphology: P-pattern ( 14% normal forms). Morphology pattern was related to other semen characteristics and IVF outcome. Results Despite corrective measures at oocyte insemination, the fertilization rate was significantly different among the three morphology groups, P Conclusions Strict morphology is an excellent biomarker of sperm fertilizing capacity, independent of motility and concentration. P-pattern sperm may denote a poorer prognosis for establishing a pregnancy, even after a satisfactory fertilization rate is achieved.
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Publications examining the impact of morphology on spontaneous pregnancy, intrauterine insemination, and in vitro fertilization reach varying conclusions.
“Despite efforts to standardize methodology for grading sperm morphology, publications examining the impact morphology on spontaneous pregnancy, intrauterine insemination, and in vitro fertilization reach varying conclusions (2, 3, 4, 5, 6, 7, 8, 9, 10).”
From Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria (2022) · cites this paper as [9]
Cites
The evaluation of morphological characteristics of human spermatozoa according to stricter criteria
Menkveld, R., Stander, F. S. H., Kotze, T. J. V., Kruger, T. F., & Zyl, J. A. V. (1990) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137150 · Cited by 677 · see citing works
Self-citationSperm selection capacity of the human zona pellucida
Menkveld, R., Franken, D. R., Kruger, T. F., Oehninger, S., & Hodgen, G. D. (1991) · Molecular Reproduction and Development · doi:10.1002/mrd.1080300409 · Cited by 129 · see citing works
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Oehninger, S., Kruger, T. F., Simon, T., Jones, D., Mayer, J., Lanzendorf, S., Toner, J. P., & Muasher, S. J. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019302 · Cited by 71 · see citing works
Self-citationHauser, R., Yogev, L., Botchan, A., Lessing, J. B., Paz, G., & Yavetz, H. (2001) · Andrologia · doi:10.1046/j.1439-0272.2001.00404.x · Cited by 49 · see citing works
Baker, K. C., Steiner, A. Z., Hansen, K. R., Barnhart, K. T., Cedars, M. I., Legro, R. S., Diamond, M. P., Krawetz, S. A., Usadi, R., Baker, V. L., et al. (2022) · F&S Reports · doi:10.1016/j.xfre.2022.03.003 · Cited by 14 · see citing works
Zhu, Y., Wu, Q.-F., Zhou, X.-J., Xin, C.-L., Ling, G., & Lu, G.-X. (2013) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2012.727061 · Cited by 13 · see citing works
- Authors
- Grow, D. R., Oehninger, S., Seltman, H. J., Toner, J. P., Swanson, R. J., Kruger, T. F., & Muasher, S. J.
- Affiliations
- Eastern Virginia Medical School (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 62
- Issue
- 3
- Pages
- 559-567
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1714560337
- Cited by
- 182
- References
- 2
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 6
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- sperm morphology, teratozoospermia, IVF outcomes, fertilization rate, implantation rate, ongoing pregnancy rate, sperm fertilizing capacity, sperm motility, sperm concentration, semen quality biomarkers
- MeSH terms
- Adult, Female, Fertilization, Fertilization in Vitro, Humans, Male, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Regression Analysis, Retrospective Studies, Sperm Motility, Spermatozoa, Cohort Studies
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