Sperm selection capacity of the human zona pellucida
Abstract
Previous hemizona assay (HZA) results have illustrated a positive and significant correlation between the percentage of morphologically normal spermatozoa in the semen and the number of spermatozoa tightly bound to the zona pellucida. The present study was designed to evaluate the morphologic features using strict criteria of spermatozoa tightly bound to the zona pellucida. Semen samples of 4 normozoospermic and 11 teratozoospermic men were used to compare the percentage of normal spermatozoa in the semen with that found 1) after swim-up separation and 2) bound to the zona under HZA conditions. The mean (+/- SEM) % normal forms for normozoospermic men in semen, after swim-up and zona-bound spermatozoa were 21.5 +/- 1.6, 27.5 +/- 2.9, and 44.8 +/- 3.4, respectively. A significantly higher % of normal forms were found among zona-bound sperm compared to swim-up forms (p = 0.02) and seminal sperm (p = 0.02). The mean % of normal sperm forms present in semen, after swim-up and zona pellucida-binding for teratozoospermic men, were 3.7 +/- 0.9, 5.8 +/- 1.6 and 15.6 +/- 3.1, respectively. Significant differences existed between the % of normal sperm forms found in the swim-up and zona-bound spermatozoa (P = less than 0.01 and P = less than 0.0003, respectively) compared to the original ejaculates. Results indicate that a selective process against abnormal spermatozoa occurs at the site of the zona pellucida.(ABSTRACT TRUNCATED AT 250 WORDS)
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The Tygerberg strict criteria were based on the observation that the morphology of spermatozoa in the cervical mucus was better than those from the semen sample and similar to the morphology required for binding to zona pellucida.
“This approach was based on the observation that the morphology of spermatozoa in the cervical mucus was better than those from the semen sample and similar to the morphology required for binding to zona pellucida (28,29).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [28]
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Self-citation
- Authors
- Menkveld, R., Franken, D. R., Kruger, T. F., Oehninger, S., & Hodgen, G. D.
- Affiliations
- Tygerberg Hospital (ZA)
- Eastern Virginia Medical School (US)
- Corresponding author
- Oehninger, Sergio
- Venue
- Molecular Reproduction and Development
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 30
- Issue
- 4
- Pages
- 346-352
- ISSN
- 1040-452X (ISSN-L)
- 1098-2795
- OpenAlex
- W1970974034
- Cited by
- 129
- References
- 36
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 4 · 2017: 12 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Reproduction and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- zona pellucida, sperm selection, teratozoospermia, sperm morphology, hemizona assay
- MeSH terms
- Cell Separation, Female, Humans, Male, Semen, Sperm-Ovum Interactions, Spermatozoa, Zona Pellucida
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