Optimal use of hormone determinations in the biochemical diagnosis of the polycystic ovary syndrome
Open accessAbstract
Objective To investigate, using logistic regression analysis and receiver operator characteristic analysis, the biochemical diagnosis of polycystic ovary syndrome (PCOS) and if it could be improved by using an array of hormone measurements chosen to yield optimal and cost-effective discrimination between women with PCOS and healthy women.Design Retrospective clinical study.Setting Outpatient clinic of reproductive endocrinology at Turku University Central Hospital, Turku, Finland.Patients Fifty-four oligomenorrheic women with PCOS diagnosed by ovarian ultrasonography, and 29 healthy regularly menstruating women with normal ovarian morphology.Main outcome measures Concentrations of LH, FSH, androstenedione (A), T, and sex hormone-binding globulin in serum.Results Luteinizing hormone, FSH and A, when used in combination, were the hormonal analytes of highest clinical utility. Diagnostic sensitivity, specificity, and overall concordance of 98%, 93%, and 96%, respectively, were attained. Each of the analytes used alone yielded lower degree of discrimination.Conclusions Simultaneous use of the levels of LH, FSH, and A in serum can be used effectively for classification between women with PCOS and healthy women.
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The remaining two studies provided insufficient lower-quality evidence to support any differences between total testosterone, SHBG and androstenedione levels with respect to their value in PCOS diagnosis.
“The remaining two studies provided insufficient lower-quality evidence to support any differences between total testosterone, SHBG and androstenedione levels with respect to their value in PCOS diagnosis. 60,62”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [62]
Three diagnostic studies (NHMRC level III-2) with low, moderate and high risk of bias compared the diagnostic accuracy of different reproductive hormone markers in serum to detect PCOS.
“Three diagnostic studies (NHMRC level III-2) with low, moderate and high risk of bias compared the diagnostic accuracy of different reproductive hormone markers in serum to detect PCOS. 60-62”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [62]
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- Authors
- Koskinen, P., Penttilä, T.-A., Anttila, L., Erkkola, R., & Irjala, K.
- Affiliations
- Turku University Hospital (FI)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 65
- Issue
- 3
- Pages
- 517-522
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2402774334
- Cited by
- 51
- References
- 26
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 4
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- polycystic ovary syndrome, biochemical diagnosis, luteinizing hormone, follicle-stimulating hormone, androstenedione, sex hormone-binding globulin, testosterone, oligomenorrhea, sensitivity and specificity
- MeSH terms
- Adolescent, Adult, Androgens, Androstenedione, Female, Follicle Stimulating Hormone, Gonadotropins, Pituitary, Humans, Luteinizing Hormone, Polycystic Ovary Syndrome, Reference Values, Retrospective Studies, Sensitivity and Specificity, Sex Hormone-Binding Globulin
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