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Cited by 348Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 107 of the 108 references it cites were found in a registry or an index.

The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism

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Wallach, Edward E., Barbieri, Robert L., Smith, Samuel, Ryan, Kenneth J.·1988·Fertility and Sterility
DOI 10.1016/s0015-0282(16)60060-2
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Abstract

The evidence that supports the hypothesis that insulin and LH both regulate ovarian androgen production was presented. The most dramatic clinical example of the association between hyperinsulinemia and hyperandrogenism is the HAIR-AN syndrome. Our hypothesis is that, in the HAIR-AN syndrome, the severe insulin resistance causes a compensatory hyperinsulinemia, which stimulates ovarian androgen production if adequate LH is present. The acanthosis nigricans is an epiphenomenon of the syndrome. Acanthosis nigricans is a dermatologic manifestation of severe insulin resistance. In vitro evidence suggests that insulin and IGF-I stimulate androgen production in incubations of human stroma and theca. The stromatropic effects of insulin may sensitize the stroma to the stimulatory effects of LH. In some hyperandrogenic-insulin-resistant women, a glucose load appears to produce an acute rise in circulating androgens. The magnitude of the rise in circulating androgens is proportional to the magnitude of the insulin response to the glucose load. These data suggest that hyperinsulinemia may play a central role in the development of ovarian hyperandrogenism.

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Show all 108 references

Research works printed but not linked: 5

  1. Futterweit, 1983, A case of bilateral dermoid cysts, insulin resistance and polycystic ovarian disease, Mt Sinai J Med (NY), 50, 251
  2. Freychet, 1984, Resistances a l’insuline, Ann Endocrinol (Paris), 45, 107
  3. Achard, 1921, Le virilisme pilaire et son association a l’insuffisance glycolytique (diabete a femmes de barbe), Bull Acad Natl Med (Paris), 86, 51
  4. Hollingsworth, 1969, Acanthosis nigricans and obesity, Arch Intern Med, 124, 481, 10.1001/archinte.1969.00300200093015 · DOI
  5. Flier, 1985, Acanthosis nigricans in obese women with hyperandrogenism, Diabetes, 34, 101, 10.2337/diab.34.2.101 · DOI

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Metadata

Authors
Wallach, E. E., Barbieri, R. L., Smith, S., & Ryan, K. J.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1988-08
Volume
50
Issue
2
Pages
197-212
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/s0015-0282(16)60060-2
OpenAlex
W194639418
Cited by
348
References
108
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 2
FWCI
10.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hyperinsulinemia, ovarian hyperandrogenism, polycystic ovary syndrome, androgen overproduction, PCOS pathogenesis, insulin resistance, hypothalamic-pituitary-ovarian axis, adrenal androgen production
MeSH terms
Acanthosis Nigricans, Androgens, Female, Humans, Hyperinsulinism, Insulin Resistance, Ovary, Polycystic Ovary Syndrome, Syndrome

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