The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Efficacy of treatment for unexplained infertility
Open accessAbstract
OBJECTIVE: To analyze the efficacy and cost-effectiveness of alternative treatments for unexplained infertility. DESIGN: Retrospective analysis of 45 published reports. SETTING: Clinical practices. PATIENT(S): Couples who met criteria for unexplained infertility. Women with Stage I or Stage II endometriosis were included. INTERVENTION(S): Observation; clomiphene citrate (CC); gonadotropins (hMG); IUI; and GIFT and IVF. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate. RESULT(S): Combined pregnancy rates per initiated cycle, adjusted for study quality, were as follows: no treatment = 1.3%-4.1%; IUI = 3.8%; CC = 5.6%; CC + IUI = 8.3%; hMG = 7.7%; hMG + IUI = 17.1%; IVF = 20.7%; GIFT = 27.0%. The estimated cost per pregnancy was $10,000 for CC + IUI, $17,000 for hMG + IUI, and $50,000 for IVF. CONCLUSION(S): Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. If this treatment fails, hMG + IUI and assisted reproduction are efficacious therapeutic options.
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Cites
Laboratory manual for the examination of human semen and semen-cervical mucus interaction.
Ma, B., Moghissi, K. S., ELIASSON, R., Ca, P., Aj, G., & Mr, P. (1980) · Cited by 2,209
Population study of causes, treatment, and outcome of infertility.
Hull, M. G., Glazener, C. M., Kelly, N. J., Conway, D. I., Foster, P. A., Hinton, R. A., Coulson, C., Lambert, P. A., Watt, E. M., & Desai, K. M. (1985) · BMJ · doi:10.1136/bmj.291.6510.1693 · Cited by 1,141
Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis
Marcoux, S., Maheux, R., & Bérubé, S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707243370401 · Cited by 948
Intracytoplasmic sperm injection
Van Steirteghem, A., Nagy, Z., Liu, J., Joris, H., Verheyen, G., Smitz, J., Tournaye, H., Liebaers, I., & Devroey, P. (1994) · Baillière's Clinical Obstetrics and Gynaecology · doi:10.1016/s0950-3552(05)80025-2 · Cited by 239
Tummon, I. S., Asher, L. J., Martin, J. S. B., & Tulandi, T. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81467-7 · Cited by 188
Deaton, J. L., Gibson, M., Blackmer, K. M., Nakajima, S. T., Badger, G. J., & Brumsted, J. R. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54009-6 · Cited by 171
Deaton, J. L., Gibson, M., Blackmer, K. M., Nakajima, S. T., Badger, G. J., & Brumsted, J. R. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90789-8 · Cited by 167
Intracytoplasmic sperm injection: a powerful tool to overcome fertilization failure
Wallach, E. E., Palermo, G. D., Cohen, J., & Rosenwaks, Z. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58257-0 · Cited by 136
The ESHRE multicentre trial on the treatment of unexplained infertility: a preliminary report*
Crosignani, P. G., Walters, D. E., & Soliani, A. (1991) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137468 · Cited by 132
Unexplained infertility—the value of Pergonal superovulation combined with intrauterine insemination
Serhal, P. F., Katz, M., Little, V., & Woronowski, H. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59825-2 · Cited by 121
Cited by
Mitwally, M. F. M. (2003) · Human Reproduction · doi:10.1093/humrep/deg311 · Cited by 344
Clomiphene citrate—end of an era? a mini-review
Homburg, R. (2005) · Human Reproduction · doi:10.1093/humrep/dei042 · Cited by 331
Merviel, P., Heraud, M. H., Grenier, N., Lourdel, E., Sanguinet, P., & Copin, H. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.058 · Cited by 295
Cicinelli, E., Matteo, M., Trojano, G., Mitola, P. C., Tinelli, R., Vitagliano, A., Crupano, F. M., Lepera, A., Miragliotta, G., & Resta, L. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12782 · Cited by 283
Mitwally, M. F. M., & Casper, R. F. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.03.006 · Cited by 102
Metadata
- Authors
- Guzick, D., Sullivan, M., Adamson, G. D., Cedars, M., Falk, R., Peterson, E., & Steinkampf, M.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 70
- Issue
- 2
- Pages
- 207-213
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1987639062
- Cited by
- 289
- References
- 47
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Guzick, D., Sullivan, M., Adamson, G. D., Cedars, M., Falk, R., Peterson, E., & Steinkampf, M. (1998). Efficacy of treatment for unexplained infertility. Fertility and Sterility. https://doi.org/10.1016/s0015-0282(98)00177-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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