The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis
Abstract
This study was initiated to test the hypothesis that treatment with clomiphene citrate (CC) and intrauterine insemination (IUI) results in increased fecundity when compared with periovulatory intercourse in couples with either unexplained infertility or surgically corrected endometriosis. Sixty-seven couples entered a randomized, prospective trial comparing CC/IUI with observation. During the study, there were 14 pregnancies in 148 treated cycles (fecundity = 0.095) compared with 5 pregnancies in 150 untreated cycles (fecundity = 0.033). Using life-table analysis and the log-rank test, the difference in fecundities was statistically significant. Pregnancy outcome was not significantly different between the two groups. When comparing conception with nonconception cycles during treatment, no differences between the size of the lead follicle or the number of dominant follicles was detected. We conclude that treatment with CC/IUI improves fecundity in couples with unexplained infertility or surgically corrected endometriosis.
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Citations
Cites
Occult ovulatory dysfunction in women with minimal endometriosis or unexplained infertility
Tummon, I. S., Maclin, V. M., Radwanska, E., Binor, Z., & Dmowski, W. P. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60304-7 · Cited by 106
Cited by
Endometriosis: pathogenesis and treatment
Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.255 · Cited by 1,940
Macer, M. L., & Taylor, H. S. (2012) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2012.10.002 · Cited by 681
Endometriosis and Infertility: Epidemiology and Evidence‐based Treatments
Ozkan, S., Murk, W., & Arici, A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1434.007 · Cited by 347
Efficacy of treatment for unexplained infertility
Guzick, D., Sullivan, M., Adamson, G. D., Cedars, M., Falk, R., Peterson, E., & Steinkampf, M. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00177-0 · Cited by 289
Fedele, L., Bianchi, S., Marchini, M., Villa, L., Brioschi, D., & Parazzini, F. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55132-2 · Cited by 79
Metadata
- Authors
- Deaton, J. L., Gibson, M., Blackmer, K. M., Nakajima, S. T., Badger, G. J., & Brumsted, J. R.
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 1991-10
- Volume
- 36
- Issue
- 2
- Pages
- 172-172
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- OpenAlex
- W151784116
- Cited by
- 167
- References
- 1
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 8736 d)
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- CoChat. (2026). Citation check: A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. https://app.cochat.ai/papers/10.1016/0020-7292(91)90789-8
- The paper
- Deaton, J. L., Gibson, M., Blackmer, K. M., Nakajima, S. T., Badger, G. J., & Brumsted, J. R. (1991). A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. International Journal of Gynecology & Obstetrics. https://doi.org/10.1016/0020-7292(91)90789-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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