Cited by 111Ovarian function and disordersReproductive Health and TechnologiesReproductive Health and Contraception

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Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women

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Young, Steven L, Opsahl, Michael S, Fritz, Marc A·1999·Fertility and Sterility

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Abstract

Objective To determine the serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate treatment in anovulatory infertile women.Design Prospective cohort.Setting Tertiary institutional infertility clinic.Patient(s) Fourteen consenting anovulatory infertile women receiving standardized, cyclic, incremental treatment with clomiphene citrate for ovulation induction.Intervention(s) Clomiphene citrate treatment (50-150 mg/d, cycle days 5-9), titrated to the minimum effective ovulation-inducing dose, was administered for three to six total cycles. Blood samples were obtained on cycle days 3 and 10 in each treatment cycle.Main outcome measure(s) Serum concentrations of enclomiphene and zuclomiphene.Result(s) Cycle day 3 zuclomiphene levels were below assay limits in all initial cycles, increased progressively across three consecutive cycles, and thereafter plateaued. Cycle day 3 enclomiphene concentrations were uniformly undetectable. Cycle day 10 enclomiphene levels increased with dose administered, but these observations were not statistically significant.Conclusion(s) Clomiphene citrate induction of ovulation results in an isomer-specific systemic accumulation of zuclomiphene across consecutive cycles of treatment. The combined maximum concentration of enclomiphene and zuclomiphene attained in practice approximates 100 nmol/L and is generally well below levels previously demonstrated to have adverse effects in vitro.

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Untitled work
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子宮内膜脱落膜化モデルを用いた, clomifene citrateおよびcyclofenilの脱落膜化に及ぼす影響の評価
恭子, 笠., 賢二, 高., 竹林, 浩., 文則, 木., 桂子, 中., & 洋一, 野. (2001) · 産婦人科の進歩 · doi:10.11437/sanpunosinpo.53.232

Authors: Young, S. L., Opsahl, M. S., & Fritz, M. A.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Genetics and IVF Institute (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Young, Steven L
ORCID: Young, Steven L
Opsahl, Michael S
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 1999-04
Volume: 71
Issue: 4
Pages: 639-644
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(98)00537-8
OpenAlex: W1984363794
Cited by: 111
References: 21
Citations by year: 2026: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 2
FWCI: 1.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8457 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Keywords: clomiphene citrate, serum drug concentration, ovulation induction, anovulatory infertility, dose titration
MeSH terms: Adult, Anovulation, Clomiphene, Female, Fertility Agents, Female, Humans, Infertility, Female, Ovulation Induction, Prospective Studies, Cohort Studies, Enclomiphene

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Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women

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