A decade’s experience with an individualized clomiphene treatment regimen including its effect on the postcoital test
Open accessAbstract
During a 10-year period, 428 women received clomiphene citrate according to a graduated therapeutic regimen in which the dose of clomiphene and the laboratory studies were individualized according to each patient's history, examination and response. Of the 428 patients, 85.3% ovulated and 42.8% conceived. The great majority of those who conceived did so during the first three ovulatory cycles. There was no evidence that clomiphene therapy was associated with the induction of another cause of infertility. Overall, 88.2% of those with no other causes for infertility who ovulated also conceived. However, only 7.8% of those who had one or more factors in addition to anovulation became pregnant. There was no evidence that clomiphene adversely affected the postcoital test, as only 15% of the patients had poor cervical mucus. The low rate of complications of this treatment, 5.1% cyst formation as well as the 14% abortion rate and the 2.6% congenital anomaly rate and the excellent gestational outcome in those who conceived support the use of this treatment regimen.
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CC may have a negative effect on other as yet undetermined fertility factors.
“and on other as yet undetermined fertility factors (10,11).”
From Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate (2001) · cites this paper as [10]
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- Authors
- Gysler, M., March, C. M., Mishell, D. R., & Bailey, E. J.
- Affiliations
- University of Southern California (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1982-02
- Volume
- 37
- Issue
- 2
- Pages
- 161-167
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2408899979
- Cited by
- 270
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 13 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 3
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- clomiphene citrate, individualized treatment regimens, ovulation induction, anovulation, infertility, postcoital test, cervical mucus, pregnancy rate, ovarian cysts, abortion, congenital malformations, pregnancy outcomes
- MeSH terms
- Amenorrhea, Clomiphene, Drug Administration Schedule, Female, Gonadotropins, Pituitary, Humans, Infertility, Female, Oligomenorrhea, Ovulation Induction, Pregnancy, Thyrotropin, 17-Ketosteroids
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