Ovarian response after laparoscopic ovarian cystectomy for endometriotic cysts in 132 monitored cycles
Open accessAbstract
Objective To investigate the follicular response of ovaries after laparoscopic ovarian cystectomy for endometriotic cysts. Design A retrospective, controlled study. Setting Obstetrics and Gynaecology Department of a university hospital. Patient(s) Patients with history of infertility who had laparoscopic ovarian cystectomy for endometriotic cysts. Intervention(s) Laparoscopic ovarian cystectomy, transvaginal ultrasound monitoring of follicles in natural cycles, stimulated cycles using clomiphene citrate (CC), chronic low-dose FSH, and "flare down" regimen. Main outcome measure(s) Follicular response of postcystectomy and normal ovaries. Result(s) For women < 35 years of age, the mean follicular response of postcystectomy ovaries was reduced significantly when compared with normal ovaries in natural cycles (0.30 versus 1.00 follicle per cycle) and in CC-stimulated cycles (0.87 versus 1.27 follicles per cycle). The mean follicular response was not statistically significantly different when the ovaries were stimulated with chronic low-dose FSH or with the flare down regimen. For women > or = 35 years, postcystectomy ovaries responded with a comparable number of follicles as the normal ovaries in natural cycles and the three different ovarian stimulation regimens. Conclusion(s) Postcystectomy ovaries showed reduced follicular response in natural and CC-stimulated cycles for women < 35 years of age. Postcystectomy ovaries produced a comparable number of follicles as normal ovaries when stimulated with gonadotropins.
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After surgery for ovarian endometriotic cysts serum AMH levels are decreased, spontaneous ovulation is reduced, and the response to ovarian hyper-stimulation is lowered, particularly in case of recurrent ovarian endometriomas.
“On the other hand, after surgery for ovarian endometriotic cysts serum AMH levels are decreased (Raffi et al., 2012; Somigliana et al., 2012), spontaneous ovulation is reduced (Loh et al., 1999; Candiani et al., 2005; Horikawa et al., 2008), and the response to ovarian hyper-stimulation is lowered (Gupta et al., 2006; Somigliana et al., 2011), particularly in case of recurrent ovarian endometrioma”
From When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement (2019) · cites this paper as Loh et al., 1999
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Garcia-Velasco, J. A., Mahutte, N. G., Corona, J., Zúñiga, V., Gilés, J., Arici, A., & Pellicer, A. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.04.006 · Cited by 214 · see citing works
Tsoumpou, I., Kyrgiou, M., Gelbaya, T. A., & Nardo, L. G. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.05.049 · Cited by 212 · see citing works
Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study
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Nickkho-Amiry, M., Savant, R., Majumder, K., Edi-O’sagie, E., & Akhtar, M. (2018) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4640-1 · Cited by 93 · see citing works
When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement
Club, E. E. T. I., Alio, L., Angioni, S., Arena, S., Bartiromo, L., Bergamini, V, Berlanda, N., Bonin, C., Busacca, M., Candiani, M., et al. (2019) · Human Reproduction Open · doi:10.1093/hropen/hoz009 · Cited by 64 · see citing works
“2012), spontaneous ovulation is reduced (Loh et al., 1999; Candiani et al., 2005; Horikawa et al., 2008), and the response to ovarian hyperstimulation is lowered (Gupta et al.”
Background
- Authors
- Loh, F.-H., Tan, A. T., Kumar, J., & Ng, S.-C.
- Affiliations
- National University of Singapore (SG)
- University of Santo Tomas Hospital (PH)
- Corresponding author
- Loh, Foo-Hoe
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 72
- Issue
- 2
- Pages
- 316-321
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2151222522
- Cited by
- 172
- References
- 4
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 10 · 2013: 7 · 2012: 5
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- laparoscopic ovarian cystectomy, ovarian endometriotic cysts, ovarian response, follicular response, ovarian reserve, infertility
- MeSH terms
- Adult, Age Factors, Anovulation, Endometriosis, Female, Follow-Up Studies, Ovarian Follicle, Humans, Infertility, Female, Menstrual Cycle, Monitoring, Physiologic, Ovarian Cysts, Ovarian Diseases, Ovary, Ovulation, Laparoscopy, Reference Values, Retrospective Studies
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