Ovarian atypical endometriosis: its close association with malignant epithelial tumours
Abstract
The incidence of ovarian atypical endometriosis and its association with malignant epithelial tumours in a consecutive series of cases during the period 1987 to 1995 were studied. Atypical glandular changes were observed in four (1.7%) of 255 ovarian endometriosis cases and one patient with ovarian atypical endometriosis developed subsequent endometrioid carcinoma in the abdominal wall. Fifty-four (24.1%) of the 224 ovarian cancers were associated with ovarian endometriosis; 21 with typical and 33 with atypical endometriosis. Clear cell carcinomas and endometrioid carcinomas were most frequently associated with endometriosis, with 54% (27 of 50 cases) and 41.9% (13 of 31), respectively. Atypical endometriosis was found in 18 clear cell carcinomas, in seven endometrioid carcinomas, in four serous carcinomas, in three mucinous borderline tumours, and in one serous borderline tumour. In 13 cases, the atypical endometriosis was in contiguity with malignant epithelial tumours. We consider that atypical endometriosis possesses a precancerous potential or is most frequently associated with clear cell and endometrioid carcinomas. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
14.7 to 22.8% of ovarian carcinomas coexist with atypical endometriosis.
“One of the reasons is that 14.7 to 22.8% of ovarian carcinomas coexist with atypical endometriosis [13,14].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [13]
Cited by
Sorted by citations
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
Jones, S., Wang, T., Shih, I., Mao, T., Nakayama, K., Roden, R. B. S., Glas, R., Slamon, D. J., Diaz, L. A., Vogelstein, B., et al. (2010) · Science · doi:10.1126/science.1196333 · Cited by 1,218 · see citing works
Cho, K. R., & Shih, I. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092246 · Cited by 694 · see citing works
Role of iron in carcinogenesis: cancer as a ferrotoxic disease
Toyokuni, S. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2008.01001.x · Cited by 552 · see citing works
Malignancy in Endometriosis: Frequency and Comparison of Ovarian and Extraovarian Types
Stern, R. C., Dash, R., Bentley, R. C., Snyder, M. J., Haney, A. F., & Robboy, S. J. (2001) · International Journal of Gynecological Pathology · doi:10.1097/00004347-200104000-00004 · Cited by 403 · see citing works
“The development of a neoplasm, be it epithelial or stromal, from atypical endometriosis, be it atypical epithelial or stromal cells, is well documented (6).”
BackgroundPrecursor lesions of ovarian epithelial malignancy
Feeley, K. M., & Wells, M. L. (2001) · Histopathology · doi:10.1046/j.1365-2559.2001.01042.x · Cited by 351 · see citing works
Origins and molecular pathology of ovarian cancer
Bell, D. A. (2005) · Modern Pathology · doi:10.1038/modpathol.3800306 · Cited by 349 · see citing works
Yamaguchi, K., Mandai, M., Toyokuni, S., Hamanishi, J., Higuchi, T., Takakura, K., & Fujii, S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1614 · Cited by 324 · see citing works
“7% (4 of 255) of cases of ordinal ovarian endometriosis (8).”
BackgroundThe Pathology of Endometriosis
Clement, P. B. (2007) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e3180ca7d7b · Cited by 326 · see citing works
“The infrequency of hyperplasia in endometriosis complicates the assessment of its premalignant potential, but it is likely similar to that of endometrial hyperplasia in view of its occasional association with a synchronous or metachronous neoplasm in the same site.(42,44,53) In one study in which 4% of endometriotic c…”
BackgroundWU, R. T., Hendrix, N. D., Kuick, R. D., Zhai, Y., Schwartz, D. R., Akyol, A., Hanash, S., Misek, D. E., Katabuchi, H., Williams, B. O., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.016 · Cited by 312 · see citing works
Marquez, R. T., Baggerly, K., Patterson, A. P., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2509 · Cited by 308 · see citing works
Endometriosis and the development of malignant tumours of the pelvis. A review of literature
Gorp, T. V., Amant, F. C., Neven, P., Vergote, I. B., & Moerman, P. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2003.03.001 · Cited by 302 · see citing works
Somigliana, E., Viganò, P., Parazzini, F., Stoppelli, S., Giambattista, E., & Vercellini, P. (2006) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.11.033 · Cited by 296 · see citing works
“Support to the idea of the ectopic tissue as the benign precursor of some ovarian cancers comes from those cases of evident histologically-proven transition from the benign disease to the malignant entity [12,14].”
BackgroundEndometriomas: their ultrasound characteristics
Holsbeke, C. V., CALSTER, B. V., Guerriero, S., Savelli, L., Paladini, D., Lissoni, A., Czekierdowski, A., Fischerová, D., Zhang, J., Mestdagh, G., et al. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7668 · Cited by 298 · see citing works
“2) Presence of papillary projection (n (%)) 67 (10) 6 (20) −10.”
The disparate origins of ovarian cancers: pathogenesis and prevention strategies
Karnezis, A. N., Cho, K. R., Gilks, C. B., Pearce, C. L., & Huntsman, D. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.113 · Cited by 294 · see citing works
Ogawa, S., Kaku, T., Amada, S., Kobayashi, H., Hirakawa, T., Ariyoshi, K., Kamura, T., & Nakano, H. (2000) · Gynecologic Oncology · doi:10.1006/gyno.2000.5765 · Cited by 279 · see citing works
Yamamoto, S., Tsuda, H., Takano, M., Tamai, S., & Matsubara, O. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.189 · Cited by 259 · see citing works
“4 Although little is known about the molecular genetic alterations underlying tumor development, a hypothesis of multistep tumorigenesis of ovarian clear-cell carcinoma, starting with histologically benign-appearing precursor lesions (ie, endometriosis and benign clear-cell adenofibroma), progressing to their atypical…”
BackgroundDiverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
WU, R. T., Zhai, Y., Fearon, E. R., & Cho, K. R. (2001) · PubMed · Cited by 256 · see citing works
Management of ovarian endometriomas
Chapron, C. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.6.591 · Cited by 244 · see citing works
The relationship of endometriosis and ovarian malignancy: a review
Nezhat, F. R., Datta, M., Hanson, V., Pejovic, T. B., Nezhat, C., & NEZHAT, C. R. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.007 · Cited by 246 · see citing works
“Independent studies show uniform results when comparing EAOC cases and non-EAOC cases regarding stage, pathologic subtype, residual tumor, and survival (105).”
ResultMechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma
Itamochi, H., Kigawa, J., & Terakawa, N. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00747.x · Cited by 237 · see citing works
Histological classification of ovarian cancer
Kaku, T., Ogawa, S., Kawano, Y., Ohishi, Y., Kobayashi, H., Hirakawa, T., & Nakano, H. (2003) · Medical Molecular Morphology · doi:10.1007/s007950300002 · Cited by 233 · see citing works
Munksgaard, P. S., & Blaakær, J. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.10.001 · Cited by 231 · see citing works
“[33], who reported that atypical endometriotic foci were observed in 61% of 54 endometriosisassociated ovarian cancers, while such foci were seen in only 1.”
BackgroundEndometriosis and ovarian cancer: Thoughts on shared pathophysiology
Ness, R. B. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.408 · Cited by 227 · see citing works
Kato, N., Sasou, S., & Motoyama, T. (2005) · Modern Pathology · doi:10.1038/modpathol.3800492 · Cited by 227 · see citing works
Parker, R. L., Dadmanesh, F., Young, R. H., & Clement, P. B. (2004) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200403000-00001 · Cited by 221 · see citing works
“Hyperplasia within endometriosis has a precancerous potential probably similar to that of the endometrium.(13,25,29)”
BackgroundEndometriosis and the neoplastic process
Varma, R., Rollason, T. P., Gupta, J. K., & Maher, E. R. (2004) · Reproduction · doi:10.1530/rep.1.00020 · Cited by 216 · see citing works
“Furthermore, the histology of EAOC (40–55% clearcell, 20–40% endometrioid and ,10% serous and mucinous subtypes) (Fukunaga et al. 1997, Yoshikawa et al. 2000, Modesitt et al. 2002) differs considerably from that seen in all ovarian cancers (FIGO 1998 annual report 55% serous, 13% mucinous, 14%…”
BackgroundInfluentialKatagiri, A., Nakayama, K., Rahman, M. T., Rahman, M., Katagiri, H., Nakayama, N., Ishikawa, M., Ishibashi, T., Iida, K., Kobayashi, H., et al. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.161 · Cited by 212 · see citing works
Modugno, F., Ness, R. B., Allen, G. O., Schildkraut, J. M., Davis, F. G., & Goodman, M. T. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.03.035 · Cited by 202 · see citing works
Plasma MicroRNAs as Novel Biomarkers for Endometriosis and Endometriosis-Associated Ovarian Cancer
Suryawanshi, S., Vlad, A. M., Lin, H.-M., Mantia-Smaldone, G., Laskey, R., Lee, M., Lin, Y., Donnellan, N., Klein-Patel, M., Lee, T., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2726 · Cited by 197 · see citing works
“of the atypical ovarian endometriosis with ovarian cancer (20), suggesting a transition spectrum of nonatypical to atypical and malignant variants (21).”
Catasús, L., Bussaglia, E., Rodríguez, I. M., Gallardo, A., Pons, C., Irving, J. A., & Prat, J. (2004) · Human Pathology · doi:10.1016/j.humpath.2004.07.019 · Cited by 181 · see citing works
Endometriosis: A Disease That Remains Enigmatic
Acién, P., & Velasco, I. (2013) · ISRN Obstetrics and Gynecology · doi:10.1155/2013/242149 · Cited by 182 · see citing works
Endometriosis and Ovarian Cancer
Wei, J., William, J., & Bulun, S. E. (2011) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e31821f4b85 · Cited by 174 · see citing works
“In ovarian cancer, atypical endometriosis is present in 23% of endometrioid carcinomas and in 36% of clear cell carcinomas (23).”
BackgroundEndometriosis-Associated Ovarian Cancer: A Review of Pathogenesis
Worley, M. J., Welch, W., Berkowitz, R. S., & Ng, S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14035367 · Cited by 175 · see citing works
“, such atypical endometriosis was identified in 54% of clear cell and 42% of endometrioid ovarian carcinomas [26].”
BackgroundLoh, F.-H., Tan, A. T., Kumar, J., & Ng, S.-C. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00207-1 · Cited by 172 · see citing works
Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors
Brinton, L. A., Sakoda, L. C., Sherman, M. E., Frederiksen, K., Kjaer, S. K., Graubard, B. I., Olsen, J. H., & Mellemkjaer, L. (2005) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0394 · Cited by 166 · see citing works
“Several studies have shown atypical endometriosis to precede clear cell or endometrioid ovarian cancers (6, 8, 29-31), suggesting that these forms of endometriosis may act as precancerous lesions similar to the connection between atypical endometrial hyperplasias and endometrial cancers.”
BackgroundMolecular genetic evidence that endometriosis is a precursor of ovarian cancer
Prowse, A. H., Manek, S., Varma, R., Liu, J., Godwin, A. K., Maher, E. R., Tomlinson, I. P. M., & Kennedy, S. (2006) · International Journal of Cancer · doi:10.1002/ijc.21845 · Cited by 165 · see citing works
“However, it has been reported that 5–10% of women with ovarian endometriomas have ovarian carcinomas,(6,14) with clear cell and endometrioid carcinomas by far the predominant EAOCs (40–55% clear cell, 20–40% endometrioid and <10% serous/mucinous).(5,8,13) Although many of the risk factors associated with both diseases…”
BackgroundEržen, M., Rakar, S., Klančar, B., & Syrjänen, K. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2001.6382 · Cited by 160 · see citing works
Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management
Mandai, M., Yamaguchi, K. D., Matsumura, N., Baba, T., & Konishi, I. (2009) · International Journal of Clinical Oncology · doi:10.1007/s10147-009-0935-y · Cited by 162 · see citing works
“Fukunaga et al.(33) reported that atypical endometriotic foci were observed in 61% of endometriosis associated with ovarian malignant tumors, while such foci were seen in only 1.”
BackgroundInfluentialRole of Endometriosis in Cancer and Tumor Development
Swiersz, L. M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02788.x · Cited by 151 · see citing works
Yamamoto, S., Tsuda, H., Takano, M., Iwaya, K., Tamai, S., & Matsubara, O. (2011) · The Journal of Pathology · doi:10.1002/path.2940 · Cited by 152 · see citing works
Kajiyama, H., Suzuki, S., Yoshihara, M., Tamauchi, S., Yoshikawa, N., Niimi, K., Shibata, K., & Kikkawa, F. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.015 · Cited by 146 · see citing works
“Furthermore, there are two biologically distinct types of this tumor: low-grade and high-grade ECs.”
BackgroundInfluentialPrecursors and pathogenesis of ovarian carcinoma
Lim, D. Y., & Oliva, E. (2013) · Pathology · doi:10.1097/pat.0b013e32835f2264 · Cited by 137 · see citing works
“7% of ovarian endometriosis unassociated with a synchronous malignancy.(89) These foci of atypical endometriosis may also harbour genetic alterations.”
BackgroundThe relation between endometriosis and ovarian cancer – a review
Heidemann, L. N., Hartwell, D., Heidemann, C. H., & Jochumsen, K. M. (2013) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.12255 · Cited by 139 · see citing works
Suryawanshi, S., Huang, X., Elishaev, E., Budiu, R. A., Zhang, L., Kim, S., Donnellan, N. M., Mantia-Smaldone, G. M., Ma, T., Tseng, G. C., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1338 · Cited by 130 · see citing works
“The intermediate, "atypical" lesions, are defined by several histologic criteria, including large nuclei with moderate to marked pleomorphism, increased nuclear-to-cytoplasmic ratio, cellular crowding, stratification, or tufting (14, 15).”
BackgroundEndometriosis-associated ovarian neoplasia
Matías‐Guiu, X., & Stewart, C. J. R. (2017) · Pathology · doi:10.1016/j.pathol.2017.10.006 · Cited by 131 · see citing works
Risk of Gynecologic Cancer According to the Type of Endometriosis
Saavalainen, L., Lassus, H. J., But, A., Tiitinen, A. E., Härkki, P., Gissler, M., Pukkala, ., & Heikinheimo, O. (2018) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002624 · Cited by 132 · see citing works
“of women 10–19 525 (1) 522 (1) 502 (1) 121 (1) 343 (2) 24 (1) 20–29 12,685 (25) 12,638 (36) 12,044 (33) 4,888 (21) 5,835 (29) 839 (35) 30–39 18,027 (36) 15,775 (45) 15,501 (42) 7,896 (34) 7,673 (38) 865 (36) 40–49 15,286 (31) 5,778 (16) 7,872 (22) 8,249 (36) 5,374 (27) 514 (22) 50–59 2,985 (6) 560 (2) 539 (1) 1,800 (8…”
Pathogenesis and the Role of ARID1A Mutation in Endometriosis-related Ovarian Neoplasms
Maeda, D., & Shih, I. (2012) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e31827bc24d · Cited by 121 · see citing works
Prevalence of Endometriosis in Ovarian Cancer
Yoshikawa, H., Jimbo, H., Okada, S., Matsumoto, K., Onda, T., Yasugi, T., & Taketani, Y. (2000) · Gynecologic and Obstetric Investigation · doi:10.1159/000052873 · Cited by 115 · see citing works
Prognostic implication of endometriosis in clear cell carcinoma of the ovary
Orezzoli, J. P., Russell, A. H., Oliva, E., Carmen, M. G. D., Eichhorn, J., & Fuller, A. F. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.05.025 · Cited by 110 · see citing works
Ovarian Cancer is an Imported Disease: Fact or Fiction?
Kuhn, E., Kurman, R. J., & Shih, I. (2012) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-011-0004-1 · Cited by 110 · see citing works
Endometriosis-associated Malignancy
Krawczyk, N., Banys-Paluchowski, M., Schmidt, D., Ulrich, U., & Fehm, T. (2016) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0035-1558239 · Cited by 107 · see citing works
“According to a number of histopathological studies endometriosis-associated ovarian cancer (EAOC) may arise from atypical endometriosis of the ovary [34,35].”
BackgroundDawson, A., Llauradó Fernandez, M., Anglesio, M., Yong, P. J., & Carey, M. S. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.803 · Cited by 106 · see citing works
Epithelial Abnormalities in Cystic Ovarian Endometriosis
Prefumo, F., Todeschini, F., Fulcheri, E., & Venturini, P. L. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2001.6529 · Cited by 98 · see citing works
“There are only a few reports in the literature regarding the clinical significance of hyperplasia and atypia in endometriosis [3–6, 13].”
BackgroundResultThe role of the fallopian tube in ovarian cancer.
Tone, A. A., Salvador, S. C., Finlayson, S. J., Tinker, A. V., Kwon, J. S., Lee, C., Cohen, T., Ehlen, T., Lee, M. H., Carey, M. S., et al. (2012) · PubMed · Cited by 98 · see citing works
Nezhat, F. R., Cohen, C. J., Rahaman, J., Gretz, H., Cole, P., & Kalir, T. (2002) · Cancer · doi:10.1002/cncr.10566 · Cited by 92 · see citing works
Prevalence of endometriosis in malignant epithelial ovary tumours
Oral, E., İlvan, Ş., Tustas, E., Körbeyli, B., Beşe, T., Demirkıran, F., Arvas, M., & Kösebay, D. (2003) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(03)00047-2 · Cited by 93 · see citing works
DNA Copy Numbers Profiles in Affinity-Purified Ovarian Clear Cell Carcinoma
Kuo, K., Mao, T., Chen, X., Feng, Y., Nakayama, K., Wang, Y., Glas, R., Ma, M. J., Kurman, R. J., Shih, I., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2105 · Cited by 93 · see citing works
Common Genetic Changes between Endometriosis and Ovarian Cancer
小畑, 孝., & Hoshiai, H. (2000) · Gynecologic and Obstetric Investigation · doi:10.1159/000052877 · Cited by 93 · see citing works
de la Cuesta, R. S., Izquierdo, M., Cañamero, M., Granizo, J. J., & Manzarbeitia, F. (2003) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(03)00367-1 · Cited by 90 · see citing works
“Other authors [4–8] have also observed an association between ovarian cancer and ectopic endometrium, but the link between these benign and malignant diseases is still not clearly understood.”
BackgroundEvidence that Endometriosis Behaves in a Malignant Manner
Thomas, E. J., & Campbell, I. (2000) · Gynecologic and Obstetric Investigation · doi:10.1159/000052872 · Cited by 87 · see citing works
Origins and molecular pathology of ovarian cancer
Bell, D. A. (2005) · Modern Pathology · doi:10.1016/s0893-3952(22)04456-8 · Cited by 89 · see citing works
McCluggage, W. G. (2019) · Histopathology · doi:10.1111/his.13970 · Cited by 88 · see citing works
Endometriosis and Ovarian Cancer: A Systematic Review
Sayasneh, A., Tsivos, D., & Crawford, R. (2011) · ISRN Obstetrics and Gynecology · doi:10.5402/2011/140310 · Cited by 82 · see citing works
“endometrioid and/or clear-cell ovarian carcinoma as a specific histological subtype [27–34].”
BackgroundEndometriosis: A Comprehensive Review
Arafah, M., Rashid, S., & Akhtar, M. (2020) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000288 · Cited by 82 · see citing works
Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy
Murakami, K., Kotani, Y., Nakai, H., & Matsumura, N. (2020) · Cancers · doi:10.3390/cancers12061676 · Cited by 80 · see citing works
“It has been reported that “atypical endometriosis”, which is assumed to be a precancerous lesion, was found in 60% of cases of endometriosis with ovarian cancer but in only 2% of cases without ovarian cancer [33].”
BackgroundMatsumoto, T., Yamazaki, M., Takahashi, H., Kajita, S., Suzuki, E., Tsuruta, T., & Saegusa, M. (2015) · American Journal of Clinical Pathology · doi:10.1309/ajcpz5t2poofmqvn · Cited by 77 · see citing works
Smooth muscle metaplasia in ovarian endometriosis
Fukunaga (2000) · Histopathology · doi:10.1046/j.1365-2559.2000.00845.x · Cited by 74 · see citing works
“Cases with epithelial metaplastic changes or malignant epithelial tumours were previously reported in detail.(1,6) The tissues were ®xed in buffered formalin and embedded in paraf®n.”
BackgroundLaparoscopic management of ovarian endometriomas: a critical review of current practice
Jones, K., & Sutton, C. (2000) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-200008000-00008 · Cited by 76 · see citing works
Zhao, C., Wu, L. S., & Barner, R. (2011) · Journal of Cancer · doi:10.7150/jca.2.94 · Cited by 75 · see citing works
Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis
Wang, S., Qiu, L., Lang, J. H., Shen, K., Yang, J. X., Huang, H. F., Pan, L. Y., & Wu, M. P. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.12.004 · Cited by 73 · see citing works
Endometriosis: candidate genes
Campbell, I. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.1.15 · Cited by 74 · see citing works
Guo, S. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.006 · Cited by 73 · see citing works
Risk factors of epithelial ovarian carcinomas among women with endometriosis: a systematic review
Thomsen, L. H., Schnack, T. H., Buchardi, K., Hummelshøj, L., Missmer, S. A., Forman, A., & Blaakær, J. (2016) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13010 · Cited by 74 · see citing works
Garry, R. (2004) · Human Reproduction · doi:10.1093/humrep/deh147 · Cited by 71 · see citing works
“In a Japanese study where the incidence of clear cell carcinoma of the ovary is substantially higher in general than in the west, the prevalence of clear cell ovarian cancer was 54% of the total and 42% of the remainder were endometriod in type (Fukunaga et al., 1997).”
BackgroundIncreased heterogeneity of chromosome 17 aneuploidy in endometriosis
Kosugi, Y., Elias, S., Malinak, L. R., Nagata, J., Isaka, K., Takayama, M., Simpson, J. L., & Bischoff, F. Z. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70649-6 · Cited by 72 · see citing works
Ovarian cancer arising in endometrioid cysts: ultrasound findings
Testa, A. C., Timmerman, D., Holsbeke, C. V., Zannoni, G. F., Fransis, S., Moerman, P., Vellone, V. G., Mascilini, F., Licameli, A., Ludovisi, M., et al. (2011) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.8970 · Cited by 70 · see citing works
Ali‐Fehmi, R., Khalifeh, I. M., Bandyopadhyay, S., Lawrence, W. D., Silva, E. G., Liao, D. J., Sarkar, F. H., & Munkarah, A. R. (2006) · International Journal of Gynecological Pathology · doi:10.1097/01.pgp.0000192274.44061.36 · Cited by 71 · see citing works
“Recent data suggest that cytologic and/or architectural atypia in endometriosis may be associated with ovarian malignancy and that a transformative process from atypical endometriosis to carcinoma may exist (7,8).”
BackgroundYamamoto, S., Tsuda, H., Takano, M., et al. (2008) · The Journal of Pathology · doi:10.1002/path.2386 · Cited by 68 · see citing works
“CCA and endometrioid adenocarcinoma [1,7,8].”
Robinson, K. A., Menias, C. O., Chen, L., Schiappacasse, G., Shaaban, A. M., Caserta, M. P., Elsayes, K. M., VanBuren, W. M., & Bolan, C. W. (2020) · Abdominal Radiology · doi:10.1007/s00261-019-01914-7 · Cited by 67 · see citing works
Loss of ARID1A/BAF250a expression in ovarian endometriosis and clear cell carcinoma.
Xiao, W., Awadallah, A., & Xin, W. (2012) · Europe PMC (PubMed Central) · Cited by 67 · see citing works
Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma
Rahman, M., Nakayama, K., Rahman, M. T., et al. (2012) · Human Pathology · doi:10.1016/j.humpath.2012.03.011 · Cited by 66 · see citing works
“Unlike serous carcinomas, for which a precursor lesion has not been identified, clear cell carcinoma develops in a stepwise fashion proceeding from atypical endometriosis to an invasive carcinoma [8-11].”
BackgroundPathology of Endometrioid and Clear Cell Carcinoma of the Ovary
Fadare, O., & Parkash, V. (2019) · Surgical pathology clinics · doi:10.1016/j.path.2019.01.009 · Cited by 65 · see citing works
Unraveling the two entities of endometrioid ovarian cancer: A single center clinical experience
Mangili, G., Bergamini, A., Taccagni, G., Gentile, C., Panina‐Bordignon, P., Viganò, P., & Candiani, M. (2012) · Gynecologic Oncology · doi:10.1016/j.ygyno.2012.05.007 · Cited by 64 · see citing works
Gütgemann, I., Lehman, N. L., Jackson, P. K., & Longacre, T. A. (2008) · Modern Pathology · doi:10.1038/modpathol.3801022 · Cited by 64 · see citing works
Rahman, M. T., Nakayama, K., Rahman, M., Nakayama, N., Ishikawa, M., Katagiri, A., Iida, K., Nakayama, S., Otsuki, Y., Shih, I., et al. (2011) · Cancer · doi:10.1002/cncr.26598 · Cited by 62 · see citing works
Viganò, P., Somigliana, E., Parazzini, F., & Vercellini, P. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.180 · Cited by 62 · see citing works
Novel insights on the malignant transformation of endometriosis into ovarian carcinoma
Gadducci, A., Lanfredini, N., & Tana, R. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.926325 · Cited by 63 · see citing works
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma
Otsuka, J., Okuda, T., Sekizawa, A., Amemiya, S., Saito, H., Okai, T., Kushima, M., & Tachikawa, T. (2004) · Medical Molecular Morphology · doi:10.1007/s00795-004-0252-5 · Cited by 60 · see citing works
“7% (4/225) of solitary ovarian endometriosis.(9) Theses findings suggest that ovarian atypical endometriosis may be a precancerous state of OEC and OCCA.”
BackgroundYamamoto, S., Tsuda, H., Yoshikawa, T., et al. (2007) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000249449.13466.3c · Cited by 62 · see citing works
“In a large series of CCAs, the frequency of associated endometriosis was reported to be as high as 54%.(5) One clinical study has also noted that 88% of ovarian CCAs were preceded by an ultrasonographically detected endometriotic cyst.”
BackgroundEndometriosis-associated cancer
Guidozzi, F. (2021) · Climacteric · doi:10.1080/13697137.2021.1948994 · Cited by 60 · see citing works
BAF250a Expression in Atypical Endometriosis and Endometriosis-Associated Ovarian Cancer
Stamp, J. P., Gilks, C. B., Wesseling, M., Eshragh, S., Ceballos, K. M., Anglesio, M. S., Kwon, J. S., Tone, A. A., Huntsman, D. D., & Carey, M. S. (2016) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000698 · Cited by 59 · see citing works
“Though this rate is higher than reported in a literature review by Van Gorp et al(5) (36% CCC, 19% EC), it was similar to (42% EC, 54% CCC) the study reported by Fukunaga et al.(10) We found that the incidence of BAF250a loss by IHC in EaOC (55% in CCC and 33% in EC) was not remarkably different than our previous expe…”
BackgroundResultInfluentialEndometriosis as a model for inflammation–hormone interactions in ovarian and breast cancers
Ness, R. B., & Modugno, F. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.009 · Cited by 59 · see citing works
Amemiya, S., Sekizawa, A., Otsuka, J., Tachikawa, T., Saito, H., & Okai, T. (2004) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2004.04.036 · Cited by 56 · see citing works
Ogawa, S., Kaku, T., Kobayashi, H., et al. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00754-6 · Cited by 55 · see citing works
Uehara, Y., Oda, K., Ikeda, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128066 · Cited by 54 · see citing works
Iron as a target of chemoprevention for longevity in humans
Toyokuni, S. (2011) · Free Radical Research · doi:10.3109/10715762.2011.564170 · Cited by 53 · see citing works
“7% of ordinary ovarian endometriosis [76].”
BackgroundFrozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls
Buza, N. (2018) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2018-0289-ra · Cited by 52 · see citing works
Higashiura, Y., Kajihara, H., Shigetomi, H., & Kobayashi, H. (2012) · Oncology Letters · doi:10.3892/ol.2012.690 · Cited by 52 · see citing works
“Gene expression profiling studies suggest that SBT is genetically distinct from high-grade serous cancers (40).”
InfluentialThe Endometriotic Tumor Microenvironment in Ovarian Cancer
Wendel, J. R. H., Wang, X., & Hawkins, S. M. (2018) · Cancers · doi:10.3390/cancers10080261 · Cited by 51 · see citing works
Endometriosis-associated Ovarian Clear Cell Carcinoma: A Special Entity?
Sun, Y., & Liu, G. (2021) · Journal of Cancer · doi:10.7150/jca.61107 · Cited by 51 · see citing works
- Authors
- FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S.
- Affiliations
- Jikei University School of Medicine (JP)
- Corresponding author
- FUKUNAGA, M.
- ORCID
- FUKUNAGA, M.
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 1997-03
- Volume
- 30
- Issue
- 3
- Pages
- 249-255
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W2084264037
- Cited by
- 333
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 19 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 17 · 2013: 14 · 2012: 22
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Histopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrioma, endometrioid carcinoma, clear cell carcinoma, ovarian cancer, serous carcinoma, serous borderline tumor, long-term follow-up
- MeSH terms
- Adult, Carcinoma, Endometriosis, Female, Humans, Middle Aged, Ovarian Diseases, Ovarian Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
