The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome
Open accessAbstract
Background & aims This study evaluated the effects of a partial 5-hydroxytryptamine (5-HT)(4) agonist, tegaserod, on gastric small bowel and colonic transit in constipation-predominant irritable bowel syndrome (IBS).Methods After a 1 week run-in period, 24 patients with constipation-predominant IBS were randomized to 1 week of tegaserod, 2 mg twice daily, or placebo treatment. Scintigraphic gastric emptying, small bowel transit, and colonic transit were determined before administration of study drug and after 1 week on the medication. Colonic transit was also measured using radiopaque markers and a single radiograph on day 5.Results Gastric emptying was unaltered by tegaserod. Proximal colonic filling at 6 hours, a measure of orocecal transit, was accelerated by tegaserod (70.4% +/- 1.3% [mean +/- SEM] vs. placebo, 46.4 +/- 1.9; P = 0.015). Proximal colonic emptying half-time and geometric center at 48 hours were also accelerated by tegaserod compared with baseline, but not compared with placebo. Mean colonic transit time was similar in both groups at baseline and after drug administration (tegaserod, 59.5 +/- 2.1 hours; placebo, 62.1 +/- 2.1 hours).Conclusions Tegaserod accelerates orocecal transit, tends to accelerate colonic transit, and deserves further study in patients with constipation-predominant IBS.
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Cites
Simplified assessment of segmental colonic transit
Metcalf, A. M., Phillips, S. F., Zinsmeister, A. R., MacCarty, R. L., Beart, R. W., & Wolff, B. G. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90837-7 · Cited by 928
Self-citationCapacity of the human colon to absorb fluid
Debongnie, J. C., & Phillips, S. F. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90246-9 · Cited by 416
Cann, P. A., Read, N. W., Brown, C., Hobson, N., & Holdsworth, C. D. (1983) · Gut · doi:10.1136/gut.24.5.405 · Cited by 365
Grider, J. R., Foxx–Orenstein, A. E., & Jin, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70203-3 · Cited by 349
Bran and irritable bowel syndrome: time for reappraisal
Francis, C. Y. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91055-3 · Cited by 315
Scintigraphic measurement of regional gut transit in idiopathic constipation.
Stivland, T., Camilleri, M., Vassallo, M., Proano, M., Rath, D. M., Brown, M. L., Thomforde, G., Pemberton, J., & Phillips, S. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90466-x · Cited by 272
Self-citationWiseman, L. R., & Faulds, D. M. (1994) · Drugs · doi:10.2165/00003495-199447010-00008 · Cited by 243
Human gastric emptying and colonic filling of solids characterized by a new method
Camilleri, M., Colemont, L. J., Phillips, S. F., Brown, M. L., Thomforde, G. M., Chapman, N., & Zinsmeister, A. R. (1989) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1989.257.2.g284 · Cited by 227
Self-citationBouras, E. P., Camilleri, M., Burton, D., & Mckinzie, S. (1999) · Gut · doi:10.1136/gut.44.5.682 · Cited by 225
Self-citationTowards a less costly but accurate test of gastric emptying and small bowel transit
Camilleri, M., Zinsmeister, A. R., Greydanus, M. P., Brown, M. L., & Proano, M. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01297027 · Cited by 198
Self-citationThe Irritable Bowel Syndrome: Mechanisms and a Practical Approach to Management
Camilleri, M., & Prather, C. M. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-1001 · Cited by 131
Self-citationTowards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders.
Camilleri, M., & Zinsmeister, A. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91092-i · Cited by 129
Self-citationColonic transit scintigraphy labeled activated charcoal compared with ion exchange pellets.
Burton, D. D., Camilleri, M., Mullan, B. P., Forstrom, L. A., & HUNG, J. C. (1997) · PubMed · Cited by 115
Self-citationScintigraphy of the whole gut: clinical evaluation of transit disorders.
Charles, F., Camilleri, M., Phillips, S. F., Thomforde, G., & Forstrom, L. A. (1995) · Mayo Clinic proceedings · doi:10.4065/70.2.113 · Cited by 111
Self-citation“Prokinetic” Treatment of Constipation-Predominant Irritable Bowel Syndrome
Outryve, M. V., Milo, R., Toussaint, J., & Eeghem, P. V. (1991) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199102000-00012 · Cited by 95
SDZ HTF 919 Stimulates Canine Colonic Motility and Transit In Vivo
Nguyen, A., Camilleri, M., Kost, L. J., Metzger, A., Sarr, M. G., Hanson, R. B., Fett, S. L., & Zinsmeister, A. R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36528-0 · Cited by 94
Self-citationFluid loading of the human colon: effects on segmental transit and stool composition.
Hammer, J., & Phillips, S. F. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90941-5 · Cited by 79
Appel, S., Kumle, A., Hubert, M., & Duvauchelle, T. (1997) · Journal of clinical pharmacology · doi:10.1002/j.1552-4604.1997.tb04785.x · Cited by 73
Appel, S., Kumle, A., & Meier, R. (1997) · Clinical pharmacology and therapy · doi:10.1016/s0009-9236(97)90050-3 · Cited by 38
Investigation into the effect of 5-hydroxytryptamine on fluid transport in the rat small intestine
McLean, P. G., & Coupar, I. M. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00095-5 · Cited by 18
High Affinity of SDZ HTF‐919 and Related Molecules for Calf and Human Caudate 5‐HT4 Receptors
Hoyer, D., Fehlmann, D., Langenegger, D., KUMMER, J., Giger, R., Mattes, H., Probst, A., & Pfannkuche, H. ‐. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10217.x · Cited by 13
In vivo modulation of left colonic motor function by a 5HT4 mechanism in healthy humans
von der Ohe, M. R., Klingenburg, S., & Goebel, H. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)83488-4 · Cited by 3
Research works printed but not linked: 3
- Pfannkuche, 1995, The properties of a new prokinetically active drug, SDZ HTF 919, Neurogastroenterol Motil, 7, 280
- Langaker, 1998, The partial 5-HT4 agonist (HTF 919) improves symptoms in constipation-predominant irritable bowel syndrome, Digestion, 59, 20
- Thompson, 1992, Functional bowel disease and functional abdominal pain, Gastroenterol Int, 5, 75
Cited by
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Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
ACG Clinical Guideline: Management of Irritable Bowel Syndrome
Lacy, B. E., Pimentel, M., Brenner, D. M., Chey, W. D., Keefer, L. A., Long, M. D., & Moshiree, B. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001036 · Cited by 893
Parkman, H. P., Hasler, W. L., & Fisher, R. S. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.055 · Cited by 738
Metadata
- Authors
- Prather, C. M., Camilleri, M., Zinsmeister, A. R., McKinzie, S., & Thomforde, G.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Camilleri, Michael
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 118
- Issue
- 3
- Pages
- 463-468
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2095055104
- Cited by
- 410
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 12
- FWCI
- 36.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK02638-01, K24DK002638, R01-DK546881)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
- Keywords
- tegaserod, irritable bowel syndrome with constipation, orocecal transit, colonic transit, gastric emptying, small intestinal transit, 5-HT4 receptor agonist, scintigraphy, radiopaque markers
- MeSH terms
- Adult, Aged, Colon, Colonic Diseases, Functional, Constipation, Double-Blind Method, Gastrointestinal Transit, Guanidines, Humans, Indoles, Intestine, Small, Middle Aged, Radionuclide Imaging, Stomach, Time Factors, Serotonin Receptor Agonists
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