Simplified assessment of segmental colonic transit
Abstract
Transit times of radiopaque markers through the human gut were measured by published techniques and compared with a simplified method. Three sets of distinctive markers were ingested by 24 healthy persons on 3 successive days. In the first part of the study, daily abdominal x-rays were taken and individual stools were collected for radiography. Mouth-to-anus transits were assessed from the fecal output of markers and mean colonic and segmental colonic transits were calculated from the daily radiographs. These established methods were then compared with estimates of total colonic and segmental transits based on a single abdominal film, taken on the fourth day. The single-film technique correlated well with values obtained from the previous, but more inconvenient, methods. Using the simpler approach, colonic transit was assessed in 49 additional healthy subjects, for a total group of 73. Total colonic transit was 35.0 +/- 2.1 h (mean +/- SE); segmental transits was 11.3 +/- 1.1 h for the right colon, 11.4 +/- 1.4 h for the left colon, and 12.4 +/- 1.1 h for the rectosigmoid. Men had significantly shorter transits for the whole colon than did women (p less than 0.05), and this difference was apparent to some extent in the right (p = 0.06) and left colon (p = 0.07) but not in the rectosigmoid. Age did not influence transit significantly nor did a small dose of supplemental fiber. The technique is simple, convenient for clinical usage, and reduces the exposure to radiation to acce…
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Distinguishing slow-transit constipation from evacuation disorders (e.g., pelvic floor dyssynergia) is a useful first step because confirmatory tests and treatment strategies differ.
“A useful first step is to distinguish slow-transit constipation from evacuation disorders (e.g., pelvic floor dyssynergia), because confirmatory tests and treatment strategies differ (Manabe et al., 2010; Metcalf et al., 1987).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Metcalf et al., 1987
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“Radiopaque markers can be used to evaluate colonic transit; this is inexpensive, simple and safe.(80,81) A radioisotope technique involves less radiation than x-ray studies and may provide more information,(82) although it is available in very few centers.”
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“Total and regional colonic transit was measured using Sitzmark capsules as previously described (13, 14).”
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Constipation: Evaluation and Treatment of Colonic and Anorectal Motility Disorders
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Constipation in Children: Novel Insight Into Epidemiology, Pathophysiology and Management
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Advances in Colonic Drug Delivery
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Diet, ageing and genetic factors in the pathogenesis of diverticular disease
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Wang, Y., Mohammed, S. D., Farmer, A. D., Wang, D., Zárate-López, N., Hobson, A. R., Hellström, P. M., Semler, J. R., Kuo, B., Rao, S. S. C., et al. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13329 · Cited by 162 · see citing works
“Median age (interquartile range) ‡ 33 (23-49) 37 (25-53) 23 (22-28) <0.”
- Authors
- Metcalf, A. M., Phillips, S. F., Zinsmeister, A. R., MacCarty, R. L., Beart, R. W., & Wolff, B. G.
- Affiliations
- Mayo Clinic (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 92
- Issue
- 1
- Pages
- 40-47
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1567581279
- Cited by
- 928
- References
- 0
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 14 · 2023: 23 · 2022: 16 · 2021: 24 · 2020: 28 · 2019: 33 · 2018: 23 · 2017: 29 · 2016: 38 · 2015: 28 · 2014: 15 · 2013: 30 · 2012: 30
- FWCI
- 14.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am032121-03, 3p30am034988-01s1)
- National Center for Research Resources (RR-585)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Surgery › Intestinal Malrotation and Obstruction Disorders
- Keywords
- colonic transit, radiopaque markers, proximal colon, left colon, rectosigmoid, dietary fiber, radiation dose reduction
- MeSH terms
- Adult, Aged, Colon, Dietary Fiber, Digestive System, Female, Gastrointestinal Motility, Humans, Male, Middle Aged, Radiography
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