Cited by 410Gastrointestinal motility and disordersEnhanced Recovery After SurgeryPelvic floor disorders treatments

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Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome

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Prather, Charlene M., Camilleri, Michael, Zinsmeister, Alan R., McKinzie, Sanna, Thomforde, George·2000·Gastroenterology

DOI 10.1016/s0016-5085(00)70251-4

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Abstract

Background & aims This study evaluated the effects of a partial 5-hydroxytryptamine (5-HT)(4) agonist, tegaserod, on gastric small bowel and colonic transit in constipation-predominant irritable bowel syndrome (IBS).Methods After a 1 week run-in period, 24 patients with constipation-predominant IBS were randomized to 1 week of tegaserod, 2 mg twice daily, or placebo treatment. Scintigraphic gastric emptying, small bowel transit, and colonic transit were determined before administration of study drug and after 1 week on the medication. Colonic transit was also measured using radiopaque markers and a single radiograph on day 5.Results Gastric emptying was unaltered by tegaserod. Proximal colonic filling at 6 hours, a measure of orocecal transit, was accelerated by tegaserod (70.4% +/- 1.3% [mean +/- SEM] vs. placebo, 46.4 +/- 1.9; P = 0.015). Proximal colonic emptying half-time and geometric center at 48 hours were also accelerated by tegaserod compared with baseline, but not compared with placebo. Mean colonic transit time was similar in both groups at baseline and after drug administration (tegaserod, 59.5 +/- 2.1 hours; placebo, 62.1 +/- 2.1 hours).Conclusions Tegaserod accelerates orocecal transit, tends to accelerate colonic transit, and deserves further study in patients with constipation-predominant IBS.

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Simplified assessment of segmental colonic transit
Metcalf, A. M., Phillips, S. F., Zinsmeister, A. R., MacCarty, R. L., Beart, R. W., & Wolff, B. G. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90837-7 · Cited by 928
Self-citation
Capacity of the human colon to absorb fluid
Debongnie, J. C., & Phillips, S. F. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90246-9 · Cited by 416
Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns.
Cann, P. A., Read, N. W., Brown, C., Hobson, N., & Holdsworth, C. D. (1983) · Gut · doi:10.1136/gut.24.5.405 · Cited by 365
5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine
Grider, J. R., Foxx–Orenstein, A. E., & Jin, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70203-3 · Cited by 349
Bran and irritable bowel syndrome: time for reappraisal
Francis, C. Y. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91055-3 · Cited by 315
Scintigraphic measurement of regional gut transit in idiopathic constipation.
Stivland, T., Camilleri, M., Vassallo, M., Proano, M., Rath, D. M., Brown, M. L., Thomforde, G., Pemberton, J., & Phillips, S. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90466-x · Cited by 272
Self-citation
Cisapride
Wiseman, L. R., & Faulds, D. M. (1994) · Drugs · doi:10.2165/00003495-199447010-00008 · Cited by 243
Human gastric emptying and colonic filling of solids characterized by a new method
Camilleri, M., Colemont, L. J., Phillips, S. F., Brown, M. L., Thomforde, G. M., Chapman, N., & Zinsmeister, A. R. (1989) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1989.257.2.g284 · Cited by 227
Self-citation
Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans
Bouras, E. P., Camilleri, M., Burton, D., & Mckinzie, S. (1999) · Gut · doi:10.1136/gut.44.5.682 · Cited by 225
Self-citation
Towards a less costly but accurate test of gastric emptying and small bowel transit
Camilleri, M., Zinsmeister, A. R., Greydanus, M. P., Brown, M. L., & Proano, M. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01297027 · Cited by 198
Self-citation

Show all 22 references

Research works printed but not linked: 3

Pfannkuche, 1995, The properties of a new prokinetically active drug, SDZ HTF 919, Neurogastroenterol Motil, 7, 280
Langaker, 1998, The partial 5-HT4 agonist (HTF 919) improves symptoms in constipation-predominant irritable bowel syndrome, Digestion, 59, 20
Thompson, 1992, Functional bowel disease and functional abdominal pain, Gastroenterol Int, 5, 75

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Authors: Prather, C. M., Camilleri, M., Zinsmeister, A. R., McKinzie, S., & Thomforde, G.
Affiliations: Mayo Clinic (US)
ORCID: Camilleri, Michael
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2000-03
Volume: 118
Issue: 3
Pages: 463-468
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/s0016-5085(00)70251-4
OpenAlex: W2095055104
Cited by: 410
References: 22
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 12
FWCI: 36.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (K24DK02638-01, K24DK002638, R01-DK546881)
National Center for Research Resources (RR-00585, M01RR000585)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
Keywords: tegaserod, irritable bowel syndrome with constipation, orocecal transit, colonic transit, gastric emptying, small intestinal transit, 5-HT4 receptor agonist, scintigraphy, radiopaque markers
MeSH terms: Adult, Aged, Colon, Colonic Diseases, Functional, Constipation, Double-Blind Method, Gastrointestinal Transit, Guanidines, Humans, Indoles, Intestine, Small, Middle Aged, Radionuclide Imaging, Stomach, Time Factors, Serotonin Receptor Agonists

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Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome

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