The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Gastrin and colorectal cancer: A prospective study
Open accessAbstract
BACKGROUND & AIMS: Gastrin is a putative promoter of colorectal carcinomas. The aim of this study was to evaluate the temporal relationship between gastrinemia and development of colorectal malignancy. METHODS: We conducted a nested case-control study among 128,992 subscribers to a health maintenance program who had participated in a multiphasic health checkup between 1964 and 1969. Serum had been frozen since the checkup and the cohort followed up for cancer. Of 1881 incident colorectal carcinoma cases, 250 were randomly selected; 1 control without cancer was matched to each case by age, sex, education, and date of serum collection. Stored sera were tested for Helicobacter pylori immunoglobulin G and for gastrin and glycine-extended gastrin. RESULTS: Verified cases included 166 colon cancers, 58 rectal cancers, and 9 with cancer in both locations. A mean of 15.3 years had elapsed between serum collection and diagnosis of cancer. Median gastrin levels were similar in cases and controls (41.7 vs. 40.7 pg/mL). However, a gastrin level above normal was associated with increased risk for colorectal malignancy (odds ratio, 3.9; 95% confidence interval, 1.5-9.8). If this association is causal, 8.6% of colorectal cancers could be attributed to high serum gastrin level. CONCLUSIONS: Hypergastrinemia is associated with an increased risk of colorectal carcinoma.
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“Last, chronic hypergastrinemia, typically present during PPI use, can promote the growth of malignant colonic epithelial cells, facilitating the deleterious sequencing adenoma-carcinoma[151-153].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [152]
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Metadata
- Authors
- Thorburn*, C. M., Friedman‡, G. D., Dickinson§, C. J., Vogelman∥, J. H., Orentreich∥, N., & Parsonnet*, #.
- Affiliations
- Kaiser Permanente (US)
- Stanford University (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 115
- Issue
- 2
- Pages
- 275-280
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2029989332
- Cited by
- 267
- References
- 42
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 14 · 2019: 12 · 2018: 9 · 2017: 12 · 2016: 13 · 2015: 1 · 2014: 7 · 2013: 19 · 2012: 12
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gastroenterology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03ca065801-01a1, DK34933)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Keywords
- gastrin, hypergastrinemia, colorectal cancer, colon cancer, rectal cancer, serum gastrin, cancer risk, Helicobacter pylori, glycine-extended gastrin, temporal relations
- MeSH terms
- Colonic Neoplasms, Female, Gastrins, Humans, Male, Middle Aged, Prospective Studies, Rectal Neoplasms, Risk Factors, Colorectal Neoplasms, Cohort Studies, Incidence, Multivariate Analysis, Odds Ratio, Case-Control Studies
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