Cited by 119Gastrointestinal motility and disordersNeuroscience and Neuropharmacology ResearchCongenital gastrointestinal and neural anomalies

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Plasticity in the enteric nervous system

Giaroni, Cristina, De Ponti, Fabrizio, Cosentino, Marco, Lecchini, Sergio, Frigo, Gianmario·1999·Gastroenterology

DOI 10.1016/s0016-5085(99)70295-7

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Abstract

Enteric ganglia can maintain integrated functions, such as the peristaltic reflex, in the absence of input from the central nervous system, which has a modulatory role. Several clinical and experimental observations suggest that homeostatic control of gut function in a changing environment may be achieved through adaptive changes occurring in the enteric ganglia. A distinctive feature of enteric ganglia, which may be crucial during the development of adaptive responses, is the vicinity of the final effector cells, which are an important source of mediators regulating cell growth. The aim of this review is to focus on the possible mechanisms underlying neuronal plasticity in the enteric nervous system and to consider approaches to the study of plasticity in this model. These include investigations of neuronal connectivity during development, adaptive mechanisms that maintain function after suppression of a specific neural input, and the possible occurrence of activity-dependent modifications of synaptic efficacy, which are thought to be important in storage of information in the brain. One of the applied aspects of the study of plasticity in the enteric nervous system is that knowledge of the underlying mechanisms may eventually enable us to develop strategies to correct neuronal alterations described in several diseases.

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Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Physiology of the Gastrointestinal Tract
Johnson, L. R. (2006) · Elsevier eBooks · doi:10.1016/b978-0-12-088394-3.x5000-4 · Cited by 4,616
The Behavior of Organisms: An Experimental Analysis
Jones, F. N., & Skinner, B. F. (1939) · The American Journal of Psychology · doi:10.2307/1416495 · Cited by 4,388
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875
Experimental models of inflammatory bowel disease
Elson, C. O., Sartor, R. B., Tennyson, G. S., & Riddell, R. H. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90599-5 · Cited by 1,212
GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Jing, S., Wen, D., Yu, Y., Holst, P. L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81311-2 · Cited by 1,169
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B. L., Pozzan, T., & Volterra, A. (1998) · Nature · doi:10.1038/34651 · Cited by 1,143
A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract
Sanders, K. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690216 · Cited by 966
Modulation of neurotransmitter release by presynaptic autoreceptors
Starke, K., Göthert, M., & Kilbinger, H. J. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.3.864 · Cited by 927

Show all 226 references

Research works printed but not linked: 10

Lakshmanan, 1997, A human mast cell (HMC-1) line which elicits neurite outgrowth expresses a distinct neurotrophin-3 prohormone (abstr), Gastroenterology, 112, A1166
Grider, 1997, Inhibition of neurite growth by BDNF, a neurotrophic factor expressed and secreted by myenteric neurons in culture (abstr), Gastroenterology, 112, A739
Grider, 1997, Stimulation of neurite growth in cultured myenteric neurons by the ciliar y neurotrophic factor, CNTF (abstr), Gastroenterology, 112, A877
Rühl, 1994, Enteroglial cells from rat myenteric plexus express interleukin-1β and interleukin-6 mRNA (abstr), Gastroenterology, 106, A561
Coulie, 1999, Recombinant human brain derived neurotrophic factor accelerates colonic transit in humans (abstr), Gastroenterology, 116, A979
Szarka, 1999, Recombinant human neurotrophin-3 accelerates small bowel and colonic transit in healthy humans and patients with constipation (abstr), Gastroenterology, 116, A1089
Sinnett, 1982, The effect of highly selective vagotomy on gastric adaptive relaxation, Br J Surg, 69, 686
Chakrabarti, 1998, Chronic morphine augments Gbg/Gsa stimulation of adenylyl cyclase: relevance to opioid tolerance, Mol Pharmacol, 54, 655, 10.1124/mol.54.6.949 · DOI
Liu, 1999, Agonist- and reflex-evoked internalization of the group 1 metabotropic glutamate receptor, mGLUR5, in neurochemically-identified enteric neurons (abstr), Gastroenterology, 116, A1031
Naliboff, 1998, Toward a biobehavioral model of visceral hypersensitivity in irritable bowel syndrome, J Psychosom Res, 45, 485

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Authors: Giaroni, C., De Ponti, F., Cosentino, M., Lecchini, S., & Frigo, G.
Affiliations: University of Pavia (IT)
University of Insubria (IT)
ORCID: Giaroni, Cristina
Cosentino, Marco
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1999-12
Volume: 117
Issue: 6
Pages: 1438-1458
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/s0016-5085(99)70295-7
OpenAlex: W2125227017
Cited by: 119
References: 226
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 1 · 2013: 4 · 2012: 1
FWCI: 1.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
IrInSubria (University of Insubria) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords: enteric nervous system, neuroplasticity, enteric ganglia, peristaltic reflex, neuronal connectivity, synaptic plasticity, enteric neurons, enteric disease
MeSH terms: Adaptation, Biological, Aging, Digestive System Physiological Phenomena, Environment, Humans, Neuronal Plasticity, Enteric Nervous System

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Plasticity in the enteric nervous system

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