The DOI matches its Crossref record; 223 of the 226 references it cites were found in a registry or an index.
Plasticity in the enteric nervous system
Abstract
Enteric ganglia can maintain integrated functions, such as the peristaltic reflex, in the absence of input from the central nervous system, which has a modulatory role. Several clinical and experimental observations suggest that homeostatic control of gut function in a changing environment may be achieved through adaptive changes occurring in the enteric ganglia. A distinctive feature of enteric ganglia, which may be crucial during the development of adaptive responses, is the vicinity of the final effector cells, which are an important source of mediators regulating cell growth. The aim of this review is to focus on the possible mechanisms underlying neuronal plasticity in the enteric nervous system and to consider approaches to the study of plasticity in this model. These include investigations of neuronal connectivity during development, adaptive mechanisms that maintain function after suppression of a specific neural input, and the possible occurrence of activity-dependent modifications of synaptic efficacy, which are thought to be important in storage of information in the brain. One of the applied aspects of the study of plasticity in the enteric nervous system is that knowledge of the underlying mechanisms may eventually enable us to develop strategies to correct neuronal alterations described in several diseases.
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“An important neurodevelopment and plasticity-related protein growth-associated protein-43 (GAP-43) is expressed in both the CNS and the ENS; it is found in high levels throughout the lifespan in the hippocampus (Simmons et al., 2008), as well as in the myenteric and submucous ganglia (Giaroni et al., 1999;Stewart et al., 1992).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Giaroni et al., 1999
Citations
Cites
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Cited by
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
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Metadata
- Authors
- Giaroni, C., De Ponti, F., Cosentino, M., Lecchini, S., & Frigo, G.
- Affiliations
- University of Pavia (IT)
- University of Insubria (IT)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 117
- Issue
- 6
- Pages
- 1438-1458
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2125227017
- Cited by
- 119
- References
- 226
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- enteric nervous system, neuroplasticity, enteric ganglia, peristaltic reflex, neuronal connectivity, synaptic plasticity, enteric neurons, enteric disease
- MeSH terms
- Adaptation, Biological, Aging, Digestive System Physiological Phenomena, Environment, Humans, Neuronal Plasticity, Enteric Nervous System
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