The DOI matches its Crossref record; 62 of the 65 references it cites were found in a registry or an index.
Application of BMP-7 to tibial non-unions: A 3-year multicenter experience
Abstract
Summary The effective treatment of the often debilitating, longlasting and large-asset-consuming complication of fracture non-unions has been in the centre of scientific interest the last decades. The use of alternative bone substitutes to the gold standard of autologous graft includes the osteoinductive molecules named bone morphogenetic proteins (BMPs). A multicenter registry and database (bmpusergroup.co.uk) focused on the application of BMP-7/OP-1 was created in December 2005. We present the preliminary results, using the prospective case-series of aseptic tibial non-unions as an example. Sixty-eight patients fulfilled the inclusion criteria for this observational study, with a minimum follow-up of 12 months. The median duration of tibial non-union prior to BMP-7 application was 23 months (range 9-317 mo). Patients had undergone a median of 2 (range 0-11) revision procedures prior to the administration of BMP-7. In 41% the application of BMP-7 was combined with revision of the fixation at the non-union site. Non-union healing was verified in 61 (89.7%) in a median period of 6.5 months (range 3-15 mo). No adverse events or complications were associated with BMP-7 application. The safety and efficacy of BMP-7 was verified in our case series, and was comparable to the existing evidence. The establishment of multicenter networks and the systematic and long-term follow- up of these patients are expected to provide further information and significantly improve our understanding of this promising osteoinductive bone substitute.
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“The family of BMPs plays a crucial role in inducing osteogenesis.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [79]
In the citing paper
“BMP-2, BMP-4, BMP-5, BMP-6, and BMP-7 are vital for bone formation and repair, with applications in open tibial fractures and non-unions [39,69,70,79].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [79]
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Metadata
- Authors
- Kanakaris, N. K., Calori, G. M., Verdonk, R., Burssens, P., Biase, P. D., Capanna, R., Vangosa, L. B., Cherubino, P., Baldo, F., Ristiniemi, J., Kontakis, G., & Giannoudis, P. V.
- Affiliations
- University of Leeds (GB)
- University of Milan (IT)
- Ghent University Hospital (BE)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Oulu University Hospital (FI)
- Corresponding author
- Giannoudis, Peter V.
- ORCID
- Venue
- Injury
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 39
- Pages
- S83-S90
- ISSN
- 0020-1383 (ISSN-L)
- OpenAlex
- W2171495416
- Cited by
- 150
- References
- 65
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 12 · 2016: 16 · 2015: 9 · 2014: 13 · 2013: 18 · 2012: 15
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Injury (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- BMP-7, OP-1, bone morphogenetic proteins, tibial nonunion, nonunion, revision fixation, treatment efficacy and safety
- MeSH terms
- Adult, Aged, Female, Fracture Fixation, Fractures, Ununited, Humans, Male, Middle Aged, Prospective Studies, Radiography, Reoperation, Tibial Fractures, Transplantation, Autologous, Treatment Outcome, Fracture Healing, Bone Morphogenetic Protein 7
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