Cited by 150Bone fractures and treatmentsBone Tissue Engineering MaterialsBone health and osteoporosis research

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Application of BMP-7 to tibial non-unions: A 3-year multicenter experience

Kanakaris, Nikolaos K., Calori, Giorgio M., Verdonk, René, Burssens, Peter, Biase, Pietro De, Capanna, Rodolfo, Vangosa, Luca Briatico, Cherubino, Paolo, Baldo, Franco, Ristiniemi, Jukka, Kontakis, George, Giannoudis, Peter V.·2008·Injury

DOI 10.1016/s0020-1383(08)70019-6

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Abstract

Summary The effective treatment of the often debilitating, longlasting and large-asset-consuming complication of fracture non-unions has been in the centre of scientific interest the last decades. The use of alternative bone substitutes to the gold standard of autologous graft includes the osteoinductive molecules named bone morphogenetic proteins (BMPs). A multicenter registry and database (bmpusergroup.co.uk) focused on the application of BMP-7/OP-1 was created in December 2005. We present the preliminary results, using the prospective case-series of aseptic tibial non-unions as an example. Sixty-eight patients fulfilled the inclusion criteria for this observational study, with a minimum follow-up of 12 months. The median duration of tibial non-union prior to BMP-7 application was 23 months (range 9-317 mo). Patients had undergone a median of 2 (range 0-11) revision procedures prior to the administration of BMP-7. In 41% the application of BMP-7 was combined with revision of the fixation at the non-union site. Non-union healing was verified in 61 (89.7%) in a median period of 6.5 months (range 3-15 mo). No adverse events or complications were associated with BMP-7 application. The safety and efficacy of BMP-7 was verified in our case series, and was comparable to the existing evidence. The establishment of multicenter networks and the systematic and long-term follow- up of these patients are expected to provide further information and significantly improve our understanding of this promising osteoinductive bone substitute.

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Authors: Kanakaris, N. K., Calori, G. M., Verdonk, R., Burssens, P., Biase, P. D., Capanna, R., Vangosa, L. B., Cherubino, P., Baldo, F., Ristiniemi, J., Kontakis, G., & Giannoudis, P. V.
Affiliations: University of Leeds (GB)
University of Milan (IT)
Ghent University Hospital (BE)
Azienda Ospedaliero-Universitaria Careggi (IT)
Oulu University Hospital (FI)
Corresponding author: Giannoudis, Peter V.
ORCID: Kanakaris, Nikolaos K.
Calori, Giorgio M.
Verdonk, René
Biase, Pietro De
Capanna, Rodolfo
Kontakis, George
Giannoudis, Peter V.
Venue: Injury
Publisher: Elsevier BV
Published: 2008-09
Volume: 39
Pages: S83-S90
ISSN: 0020-1383 (ISSN-L)
DOI: 10.1016/s0020-1383(08)70019-6
OpenAlex: W2171495416
Cited by: 150
References: 65
Citations by year: 2026: 4 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 12 · 2016: 16 · 2015: 9 · 2014: 13 · 2013: 18 · 2012: 15
FWCI: 10.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Injury (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
IrInSubria (University of Insubria) (submittedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: BMP-7, OP-1, bone morphogenetic proteins, tibial nonunion, nonunion, revision fixation, treatment efficacy and safety
MeSH terms: Adult, Aged, Female, Fracture Fixation, Fractures, Ununited, Humans, Male, Middle Aged, Prospective Studies, Radiography, Reoperation, Tibial Fractures, Transplantation, Autologous, Treatment Outcome, Fracture Healing, Bone Morphogenetic Protein 7

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Application of BMP-7 to tibial non-unions: A 3-year multicenter experience

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