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Application of BMP-7 to tibial non-unions: A 3-year multicenter experience
Abstract
Summary The effective treatment of the often debilitating, longlasting and large-asset-consuming complication of fracture non-unions has been in the centre of scientific interest the last decades. The use of alternative bone substitutes to the gold standard of autologous graft includes the osteoinductive molecules named bone morphogenetic proteins (BMPs). A multicenter registry and database (bmpusergroup.co.uk) focused on the application of BMP-7/OP-1 was created in December 2005. We present the preliminary results, using the prospective case-series of aseptic tibial non-unions as an example. Sixty-eight patients fulfilled the inclusion criteria for this observational study, with a minimum follow-up of 12 months. The median duration of tibial non-union prior to BMP-7 application was 23 months (range 9-317 mo). Patients had undergone a median of 2 (range 0-11) revision procedures prior to the administration of BMP-7. In 41% the application of BMP-7 was combined with revision of the fixation at the non-union site. Non-union healing was verified in 61 (89.7%) in a median period of 6.5 months (range 3-15 mo). No adverse events or complications were associated with BMP-7 application. The safety and efficacy of BMP-7 was verified in our case series, and was comparable to the existing evidence. The establishment of multicenter networks and the systematic and long-term follow- up of these patients are expected to provide further information and significantly improve our understanding of this promising osteoinductive bone substitute.
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“The family of BMPs plays a crucial role in inducing osteogenesis.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [79]
In the citing paper
“BMP-2, BMP-4, BMP-5, BMP-6, and BMP-7 are vital for bone formation and repair, with applications in open tibial fractures and non-unions [39,69,70,79].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [79]
Citations
Cites
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736
Bone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529
Problems in the Management of Type III (Severe) Open Fractures
Gustilo, R. B., Mendoza, R. M., & Williams, D. N. (1984) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198408000-00009 · Cited by 2,394
Morbidity at Bone Graft Donor Sites
Younger, E. W., & Chapman, M. W. (1989) · Journal of Orthopaedic Trauma · doi:10.1097/00005131-198909000-00002 · Cited by 2,020
GOVENDER, S., CSIMMA, C., GENANT, H. K., & VALENTIN-OPRAN, A. (2002) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200212000-00001 · Cited by 1,308
Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions
Friedlaender, G. E., Perry, C. R., Cole, J. D., Cook, S. D., Cierný, G., Muschler, G. F., Zych, G. A., Calhoun, J. H., LaForte, A. J., & Yin, S. (2001) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200100002-00010 · Cited by 956
Autogenous Iliac Crest Bone Graft: Complications and Functional Assessment
Goulet, J. A., Senunas, L. E., DeSilva, G. L., & Greenfield, M. L. V. H. (1997) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199706000-00011 · Cited by 911
Purification and characterization of other distinct bone-inducing factors.
Wang, E. A., Rosen, V., Cordes, P., Hewick, R. M., Kriz, M. J., Luxenberg, D. P., Sibley, B. S., & Wozney, J. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9484 · Cited by 614
Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions?
Sen, M., & Miclau, T. (2007) · Injury · doi:10.1016/j.injury.2007.02.012 · Cited by 547
Nonunion of the femoral diaphysis
Giannoudis, P. V., MacDonald, D. A., Matthews, S. J., Smith, R. M., Furlong, A. J., & de Boer, P. (2000) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.82b5.9899 · Cited by 413
Self-citationSafety Profile for the Clinical Use of Bone Morphogenetic Proteins in the Spine
Poynton, A. R., & Lane, J. M. (2002) · Spine · doi:10.1097/00007632-200208151-00010 · Cited by 403
Castillo, R. C., Bosse, M. J., MacKenzie, E. J., & Patterson, B. M. (2005) · Journal of Orthopaedic Trauma · doi:10.1097/00005131-200503000-00001 · Cited by 400
Garrison, K. R., Donell, S. T., Ryder, J. J., Shemilt, I., Mugford, M., Harvey, I. M., & Song, F. (2007) · Health Technology Assessment · doi:10.3310/hta11300 · Cited by 340
Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures
Starr, A. J. (2003) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200310000-00027 · Cited by 297
Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion
White, A. P., Vaccaro, A. R., Hall, J. A., Whang, P. G., Friel, B. C., & McKee, M. D. (2007) · International Orthopaedics · doi:10.1007/s00264-007-0422-x · Cited by 270
The health economics of the treatment of long-bone non-unions
Kanakaris, N. K., & Giannoudis, P. V. (2007) · Injury · doi:10.1016/s0020-1383(07)80012-x · Cited by 256
Self-citationMegas, P. (2005) · Injury · doi:10.1016/j.injury.2005.10.008 · Cited by 249
Growth factor stimulation of bone healing
Lind, M. (1998) · Acta Orthopaedica Scandinavica · doi:10.1080/17453674.1998.11744808 · Cited by 213
Termaat, M. F. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.d.02585 · Cited by 210
Immune Responses to Allogeneic and Xenogeneic Implants of Collagen and Collagen Derivatives
Delustro, F. A., Dasch, J. R., Keefe, J., & Ellingsworth, L. R. (1990) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199011000-00043 · Cited by 210
Exchange Nailing of Ununited Fractures
Brinker, M. R., & O’Connor, D. P. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200701000-00025 · Cited by 197
Resistant Nonunions and Partial or Complete Segmental Defects of Long Bones
Johnson, E. E., Urist, M. R., & Finerman, G. A. M. (1992) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199204000-00028 · Cited by 189
Boskey, A. L., DiCarlo, E. F., Paschalis, E. P., West, P. A., & Mendelsohn, R. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1992-3 · Cited by 187
Biase, P. D., & Capanna, R. (2005) · Injury · doi:10.1016/j.injury.2005.07.034 · Cited by 172
Self-citationFemoral Nonunion: Risk Factors and Treatment Options
Lynch, J. R., Taitsman, L. A., Barei, D. P., & Nork, S. E. (2008) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200802000-00006 · Cited by 166
Phieffer, L. S., & Goulet, J. A. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200601000-00026 · Cited by 162
Application of recombinant BMP-7 on persistent upper and lower limb non-unions
Dimitriou, R. I., Dahabreh, Z., Katsoulis, E., Matthews, S. J., Branfoot, T., & Giannoudis, P. V. (2005) · Injury · doi:10.1016/j.injury.2005.10.010 · Cited by 151
Self-citationSeven Yearsʼ Experience With Integra as a Reconstructive Tool
Jeng, J. C., Fidler, P. E., Sokolich, J. C., Jaskille, A. D., Khan, S., White, P. M., Street, J. H., Light, T. D., & Jordan, M. H. (2007) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31802cb83f · Cited by 130
Nonsteroidal Anti-Inflammatory Drug-Induced Fracture Nonunion: An Inhibition of Angiogenesis?
Murnaghan, M., Li, G., & Marsh, D. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.00454 · Cited by 127
Johnson, E. E., Urist, M. R., & Finerman, G. A. M. (1990) · PubMed · Cited by 127
Laursen, M., Høy, K., Hansen, E. S., Gelineck, J., Christensen, F. B., & Bünger, C. E. (1999) · European Spine Journal · doi:10.1007/s005860050210 · Cited by 123
Niikura, T., Hak, D. J., & Reddi, A. H. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20182 · Cited by 112
Dahabreh, Z., Dimitriou, R. I., & Giannoudis, P. V. (2006) · Injury · doi:10.1016/j.injury.2006.08.055 · Cited by 110
Self-citationGiannoudis, P. V., Kanakaris, N. K., & Einhorn, T. A. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0441-x · Cited by 108
Self-citationUse of Bone Morphogenetic Proteins for Musculoskeletal Applications
Mont, M. A., Ragland, P. S., Biggins, B., Friedlaender, G. E., Patel, T. C., Cook, S. D., Etienne, G., Shimmin, A., Kildey, R., Rueger, D. C., et al. (2004) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200412002-00008 · Cited by 106
Use of bone morphogenetic proteins for treatment of non-unions and future perspectives
Schmidmaier, G., Schwabe, P., Wildemann, B., & Haas, N. P. (2007) · Injury · doi:10.1016/s0020-1383(08)70007-x · Cited by 100
Vascularised bone grafts for the management of non-union
Soucacos, P. N., Dailiana, Z. H., Beris, A. E., & Johnson, E. O. (2006) · Injury · doi:10.1016/j.injury.2006.02.040 · Cited by 85
Kanakaris, N. K., Paliobeis, C. P., Manidakis, N., & Giannoudis, P. V. (2007) · Injury · doi:10.1016/s0020-1383(07)80011-8 · Cited by 78
Self-citationAvailable biological treatments for complex non-unions
Mahendra, A., & MacLean, A. K. (2007) · Injury · doi:10.1016/s0020-1383(08)70004-4 · Cited by 77
Tibial Nonunion: Treatment Alternatives
Wiss, D. A., & Stetson, W. B. (1996) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-199609000-00003 · Cited by 76
Bone morphogenic protein and its application in trauma cases: A current concept update
Bagaria, V. B., Patil, N., Vikram, S., & Chadda, A. (2007) · Injury · doi:10.1016/j.injury.2006.12.012 · Cited by 73
Giannoudis, P. V., Psarakis, S. A., Kanakaris, N. K., & Pape, H. (2007) · Injury · doi:10.1016/s0020-1383(08)70008-1 · Cited by 71
Self-citationGriffin, X. L., Warner, F., & Costa, M. L. (2008) · Injury · doi:10.1016/j.injury.2007.12.014 · Cited by 67
Are there advances in the treatment of extracapsular hip fractures in the elderly?
STERN, R. E. (2007) · Injury · doi:10.1016/j.injury.2007.08.015 · Cited by 67
Calori, G. M., D’Avino, M., Tagliabue, L., Albisetti, W., d’Imporzano, M., & Peretti, G. (2006) · Injury · doi:10.1016/j.injury.2006.08.023 · Cited by 66
Self-citationRonga, M., Baldo, F., Zappalà, G., & Cherubino, P. (2006) · Injury · doi:10.1016/j.injury.2006.08.024 · Cited by 65
Self-citationApplication of bone morphogenetic proteins in orthopaedic practice: their efficacy and side effects
Harwood, P. J., & Giannoudis, P. V. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.1.75 · Cited by 64
Self-citationSzpalski, M., & Gunzburg, R. (2005) · PubMed · Cited by 62
Discovery and development of BMPs
Dimitriou, R. I., & Giannoudis, P. V. (2005) · Injury · doi:10.1016/j.injury.2005.07.031 · Cited by 62
Self-citationLong term results of compartment syndrome of the lower limb in polytraumatised patients
Frink, M., Klaus, A.-K., Küther, G., Probst, C. P., Gösling, T., Kobbe, P., Hildebrand, F., Richter, M., Giannoudis, P. V., Krettek, C., et al. (2007) · Injury · doi:10.1016/j.injury.2006.12.021 · Cited by 61
Self-citationFemoral diaphyseal aseptic non-unions: Is there an ideal method of treatment?
Crowley, D. J., Kanakaris, N. K., & Giannoudis, P. V. (2007) · Injury · doi:10.1016/s0020-1383(07)80010-6 · Cited by 57
Self-citationManagement of nonunion with distraction osteogenesis
Kanellopoulos, A. D., & Soucacos, P. N. (2006) · Injury · doi:10.1016/j.injury.2006.02.041 · Cited by 57
Kärrholm, J., Hourigan, P. G., Timperley, J. A., & Razaznejad, R. (2006) · Acta Orthopaedica · doi:10.1080/17453670610045687 · Cited by 52
Mechanical and biological treatment of long bone non-unions
Biasibetti, A., Aloj, D. C., Gregorio, G. D., Massè, A., & Salomone, C. (2005) · Injury · doi:10.1016/j.injury.2005.10.013 · Cited by 50
Therapieerfolg bei atrophen Tibiaschaftpseudarthrosen
Zimmermann, G., Müller, U., Löffler, C., Wentzensen, A., & Moghaddam, A. (2007) · Der Unfallchirurg · doi:10.1007/s00113-007-1347-y · Cited by 41
Electric stimulation and hyperbaric oxygen therapy in the treatment of nonunions
Karamitros, A., Kalentzos, V. N., & Soucacos, P. N. (2006) · Injury · doi:10.1016/j.injury.2006.02.042 · Cited by 36
Osteogenic protein-1 in treatment of tibial nonunions: current status.
Friedlaender, G. E. (2004) · PubMed · Cited by 30
Transcriptomics and proteomics: Advancing the understanding of genetic basis of fracture healing
Tsiridis, E. E., & Giannoudis, P. V. (2006) · Injury · doi:10.1016/j.injury.2006.02.036 · Cited by 28
Self-citationNilsson, O., & Urist, M. R. (1991) · International Orthopaedics · doi:10.1007/bf00192304 · Cited by 27
Immunologic evidence of a bone morphogenetic protein in the milieu intérieur.
Mr, U., NILSSON, O. S., Hudak, R., Huo, Y. K., Rasmussen, J., Hirota, W. K., & Lietze, A. (1985) · PubMed · Cited by 27
Biotherapeutics in Orthopaedic Medicine
Puleo, D. A. (2003) · BioDrugs · doi:10.2165/00063030-200317050-00001 · Cited by 13
Engen, A. V., & Vinken, A. (2002) · Value in Health · doi:10.1016/s1098-3015(10)61523-9 · Cited by 5
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Calori, G. M., Mazza, E., Colombo, M., & Ripamonti, C. (2011) · Injury · doi:10.1016/j.injury.2011.06.011 · Cited by 435
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Metadata
- Authors
- Kanakaris, N. K., Calori, G. M., Verdonk, R., Burssens, P., Biase, P. D., Capanna, R., Vangosa, L. B., Cherubino, P., Baldo, F., Ristiniemi, J., Kontakis, G., & Giannoudis, P. V.
- Affiliations
- University of Leeds (GB)
- University of Milan (IT)
- Ghent University Hospital (BE)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Oulu University Hospital (FI)
- Corresponding author
- Giannoudis, Peter V.
- ORCID
- Venue
- Injury
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 39
- Pages
- S83-S90
- ISSN
- 0020-1383 (ISSN-L)
- OpenAlex
- W2171495416
- Cited by
- 150
- References
- 65
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 12 · 2016: 16 · 2015: 9 · 2014: 13 · 2013: 18 · 2012: 15
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Injury (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- BMP-7, OP-1, bone morphogenetic proteins, tibial nonunion, nonunion, revision fixation, treatment efficacy and safety
- MeSH terms
- Adult, Aged, Female, Fracture Fixation, Fractures, Ununited, Humans, Male, Middle Aged, Prospective Studies, Radiography, Reoperation, Tibial Fractures, Transplantation, Autologous, Treatment Outcome, Fracture Healing, Bone Morphogenetic Protein 7
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