Genes and genomes of Necator americanus and related hookworms
Abstract
The human hookworms (Necator americanus and Ancylostoma duodenale) infect over one billion people. The phylogenetic relationships of the human hookworms suggest independent acquisition of the human host. The hookworms probably have a haploid chromosome number n = 6, and an XX-XO sex determination mechanism is likely to be used. Genetic and molecular research on hookworms is in its infancy, but several important genes and gene products have already been identified. Of note are cathepsin genes, a family of secreted proteins known as Ancylostoma activation-associated proteins and a family of anticoagulants. The inception of an expressed sequence tag program on the human hookworm, N. americanus, promises to yield many new genes with novel functions in the biology of these important parasites.
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A. caninum is extremely close phylogenetically to the hookworm species of humans, A. duodenale, A. ceylanicum and Necator americanus.
“Ancylostoma caninum is extremely close phylogenetically to the hookworm species of humans, A. duodenale, A. ceylanicum and Necator americanus [90].”
From Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? (2019) · cites this paper as [90]
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The Origin of Parasites of Humans
Ferreira, L. F., Reinhard, K. J., & de Araújo, A. J. G. (2014) · Editora FIOCRUZ eBooks · doi:10.7476/9788575415986.0009 · Cited by 6 · see citing works
Molecular Systematics of Parasitic Nematodes
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Morfología y citogenética de nemátodos Rhabditida parasitando arañas y escorpiones en Argentina
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Relationship of Nematodes and Humans in Prehistoric Times: A Paleoparasitological Perspective
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7. Origem dos parasitos humanos
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- Authors
- Blaxter, M.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Blaxter, Mark
- ORCID
- Blaxter, Mark
- Venue
- International Journal for Parasitology
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 30
- Issue
- 4
- Pages
- 347-355
- ISSN
- 0020-7519 (ISSN-L)
- OpenAlex
- W1987169735
- Cited by
- 45
- References
- 71
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 2 · 2019: 3 · 2018: 1 · 2016: 1 · 2014: 4
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal for Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Physical Sciences › Environmental Science › Ecology › Parasite Biology and Host Interactions
- Keywords
- Necator americanus, Ancylostoma duodenale, haploid chromosome number, anticoagulant proteins, expressed sequence tags
- MeSH terms
- Animals, Host-Parasite Interactions, Humans, Phylogeny, Genome, Necator americanus
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