Cited by 45Parasites and Host InteractionsHelminth infection and controlParasite Biology and Host Interactions

Genes and genomes of Necator americanus and related hookworms

Blaxter, Mark·2000·International Journal for Parasitology

Abstract

The human hookworms (Necator americanus and Ancylostoma duodenale) infect over one billion people. The phylogenetic relationships of the human hookworms suggest independent acquisition of the human host. The hookworms probably have a haploid chromosome number n = 6, and an XX-XO sex determination mechanism is likely to be used. Genetic and molecular research on hookworms is in its infancy, but several important genes and gene products have already been identified. Of note are cathepsin genes, a family of secreted proteins known as Ancylostoma activation-associated proteins and a family of anticoagulants. The inception of an expressed sequence tag program on the human hookworm, N. americanus, promises to yield many new genes with novel functions in the biology of these important parasites.

Integrity signals

Registry

Crossref · 10.1016/s0020-7519(99)00198-8

Cites

71 of 71 references verified0 citation errors · 0 not checkable

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  • A. caninum is extremely close phylogenetically to the hookworm species of humans, A. duodenale, A. ceylanicum and Necator americanus.

    “Ancylostoma caninum is extremely close phylogenetically to the hookworm species of humans, A. duodenale, A. ceylanicum and Necator americanus [90].”

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Authors
Blaxter, M.
Affiliations
University of Edinburgh (GB)
Corresponding author
Blaxter, Mark
Venue
International Journal for Parasitology
Publisher
Elsevier BV
Published
2000-04
Volume
30
Issue
4
Pages
347-355
ISSN
0020-7519 (ISSN-L)
OpenAlex
W1987169735
Cited by
45
References
71
Citations by year
2025: 2 · 2023: 2 · 2022: 2 · 2019: 3 · 2018: 1 · 2016: 1 · 2014: 4
FWCI
0.79
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal for Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministerio de Economía y Competitividad
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Physical Sciences › Environmental Science › Ecology › Parasite Biology and Host Interactions
Keywords
Necator americanus, Ancylostoma duodenale, haploid chromosome number, anticoagulant proteins, expressed sequence tags
MeSH terms
Animals, Host-Parasite Interactions, Humans, Phylogeny, Genome, Necator americanus

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