Cited by 101Paraoxonase enzyme and polymorphismsAntioxidant Activity and Oxidative StressNutritional Studies and Diet

Dietary determinants of serum paraoxonase activity in healthy humans

Kleemola, Päivi, Freese, Riitta, Jauhiainen, Matti, Pahlman, Raija, Alfthan, Georg, Mutanen, Marja·2002·Atherosclerosis

Abstract

The associations between habitual diet and a variety of markers of lipid peroxidation or oxidative stress in a group of 95 healthy comparatively young Finnish volunteers (24 male and 71 females) were investigated. The habitual diet of the subjects was evaluated with a 3-day food record. The following biochemical parameters related to lipid peroxidation or oxidative stress were measured: lagtime of Cu2+ induced LDL oxidation in vitro, lipid hydroperoxides and Schiff bases produced during the LDL oxidation test, malondialdehyde measured as thiobarbituric acid-reactive substances from native LDL and Cu2+ oxidized LDL, serum paraoxonase (PON) activity. Serum PON activity showed most constantly associations with habitual diet. PON activity correlated negatively (r=-0.31 to -0.37) with intake of vegetables, total and water-soluble fiber, as well as intake of beta-carotene. Highly significant difference (P=0.005) in PON activity between lowest (<135 g/day) and highest (>256 g/day) vegetable intake quartiles was found. Malondialdehyde levels showed conflicting associations with diet. The results suggest that the significantly lower PON activity associated with high vegetable intake needs to be studied further.

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Crossref · 10.1016/s0021-9150(01)00594-9

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Authors
Kleemola, P., Freese, R., Jauhiainen, M., Pahlman, R., Alfthan, G., & Mutanen, M.
Affiliations
University of Helsinki (FI)
Corresponding author
Mutanen, Marja
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2002-02
Volume
160
Issue
2
Pages
425-432
ISSN
0021-9150 (ISSN-L)
OpenAlex
W2127387592
Cited by
101
References
47
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 4 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 3
FWCI
5.03
Type
journal article
Language
en
Open access
closed
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
serum paraoxonase activity, dietary factors, lipid peroxidation, oxidative stress, vegetable consumption, dietary fiber, beta-carotene, malondialdehyde, LDL oxidation, lipid hydroperoxides, Schiff base, healthy young adults
MeSH terms
Adult, Diet, Esterases, Female, Humans, Lipoproteins, LDL, Male, Malondialdehyde, Middle Aged, Oxidation-Reduction, Lipid Peroxidation, Oxidative Stress, Aryldialkylphosphatase

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