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Cited by 78Fatty Acid Research and HealthAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans

Turpeinen, A.M., Basu, S., Mutanen, M.·1998·Prostaglandins Leukotrienes and Essential Fatty Acids
DOI 10.1016/s0952-3278(98)90067-9
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Abstract

Evidence from in vitro studies shows that increased intake of polyunsaturated fatty acids leads to increased oxidative stress, which may be associated with endothelial damage. We measured the urinary levels of 8-iso-PGF2alpha and nitric oxide metabolites as well as plasma sICAM-1 levels from healthy subjects after strictly controlled diets rich in either linoleic acid (LA, C18:2 n-6) or oleic acid (OA, C18:1 n-9). Thirty-eight volunteers (20 women and 18 men, mean age 27 years) consumed a baseline diet rich in saturated fatty acids (SFA) for 4 weeks and were then switched to either a high LA diet (11.5 en%) or a high OA diet (18.0 en%) also for 4 weeks. During the LA and OA diets, nearly all food was provided for the whole day. A control group of 13 subjects consumed their habitual diet throughout the study. Urinary excretion of 8-iso-PGF2alpha was significantly increased after the LA diet (170 vs 241 ng/mmol creatinine, P=0.04), whereas the urinary concentration of nitric oxide metabolites decreased (4.2 vs 2.6 mg/mmol creatinine, P=0.03). No significant changes were seen in the OA group. Significant differences between the LA and control group were found for both 8-oxo-PGF2alpha (P=0.03) and NO (P=0.02), whereas the OA and LA groups did not differ with respect to any parameter. Also plasma sICAM-1 remained unchanged in both groups throughout the study. In conclusion, the high-LA diet increased oxidative stress and affected endothelial function in a way which may in the long-term predispose to endothelial dysfunction.

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Authors
Turpeinen, A. M., Basu, S., & Mutanen, M.
Affiliations
  • University of Helsinki (FI)
  • Uppsala University (SE)
Corresponding author
Turpeinen, A.M.
ORCID
Turpeinen, A.M.
Venue
Prostaglandins Leukotrienes and Essential Fatty Acids
Publisher
Elsevier BV
Published
1998-09
Volume
59
Issue
3
Pages
229-233
ISSN
0952-3278 (ISSN-L)
DOI
10.1016/s0952-3278(98)90067-9
OpenAlex
W2083216589
Cited by
78
References
33
Citations by year
2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 4
FWCI
2.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Prostaglandins Leukotrienes and Essential Fatty Acids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
linoleic acid, oleic acid, dietary fatty acids, oxidative stress, nitric oxide metabolism, 8-isoprostane, nitric oxide metabolites, sICAM-1, endothelial dysfunction, polyunsaturated fatty acids, saturated fatty acids, urinary biomarkers
MeSH terms
Adult, Diet, Energy Metabolism, Female, Humans, Male, Middle Aged, Nitric Oxide, Vitamin E, Dinoprost, Oxidative Stress, Intercellular Adhesion Molecule-1, Oleic Acid, Linoleic Acid, F2-Isoprostanes

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