The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure
Abstract
To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex-matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose-response relationship with arsenic-related ISHD was observed for serum level of alpha- and beta-carotene, but not for serum levels of retinol, lycopene and alpha-tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Other symptoms may include hyperpigmentation, palmar and solar keratosis, diarrhoea and vomiting, skin changes and neuropathy,36 ischemic heart disease, 38 confusion and memory loss,23 respiratory disease and a higher risk of diabetes.39,40”
Citations
Cites
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,090
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,345
Atherosclerosis: Basic Mechanisms
Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., & Lusis, A. J. (1995) · Circulation · doi:10.1161/01.cir.91.9.2488 · Cited by 1,730
Blood Pressure, Systolic and Diastolic, and Cardiovascular Risks: US Population Data
Stamler, J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410050036006 · Cited by 1,015
Antioxidant functions of carotenoids
Krinsky, N. I. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90143-3 · Cited by 928
Diet and health: Implications for reducing chronic disease risk
(1990) · Journal of Nutrition Education · doi:10.1016/s0022-3182(12)80292-5 · Cited by 861
Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic
Tseng, W.-P. (1977) · Environmental Health Perspectives · doi:10.1289/ehp.7719109 · Cited by 730
Zhang, L., Cooney, R. V., & Bertram, J. S. (1991) · Carcinogenesis · doi:10.1093/carcin/12.11.2109 · Cited by 513
Carotenoids and the Immune Response
Bendich, A. (1989) · Journal of Nutrition · doi:10.1093/jn/119.1.112 · Cited by 462
Research works printed but not linked: 5
- Grobe, 1976, Peripheral circulatory disorders and acrocyanosis with arsenic, Berufs Dermatosen, 24, 78
- Wu, 1961, Epidemiologic studies on blackfoot disease: I. Prevalence and incidence of the disease by age, sex, occupation and geographical distribution, Mem College Med Natl Taiwan Univ, 7, 33
- Kuo TL. Arsenic content of artesian well water in endemic area of chronic arsenic poisoning. Reports, Institute of Pathology, National Taiwan University 1964; 20:7–13.
- Yeh, 1980, Trace element in water samples from the endemic area of blackfoot disease and biospecimens from blackfoot disease patients: a preliminary report, Blackfoot Dis Res Rep, 8, 22
- Stamler J, Ruth KJ, Liu K, Shekkele RB. Dietary antioxidants and blood pressure change in the western electric study (abstract). 34th Annual Conference on Cardiovascular Disease Epidemiology and Prevention. Tampa, Florida, 1993.
Cited by
Sorted by citations
Items 101–159 of 159
Fowler, B. A., Chou, C.-Y., Jones, R. L., & Chen, C. (2007) · Elsevier eBooks · doi:10.1016/b978-012369413-3/50074-4 · Cited by 21
Self-citationLiao, Y., Li, W.-F., Chen, C., Prineas, R. J., Chen, W. J., Zhang, Z., Sun, C.-W., & Wang, S. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.12.017 · Cited by 19
Self-citationChung, C., Pu, Y., Chen, Y., Su, C., Wu, C., Shiue, H.-S., Huang, C., & Hsueh, Y. (2011) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2010.11.037 · Cited by 18
Self-citationLiang, C., Jang, C., Chen, C.-F., & Chen, J. (2016) · Environmental Monitoring and Assessment · doi:10.1007/s10661-016-5414-0 · Cited by 14
Self-citationA Clinical Perspective on Arsenic Exposure and Development of Atherosclerotic Cardiovascular Disease
Kaur, G., Desai, K. P., Chang, I. Y., Newman, J. D., Mathew, R. O., Bangalore, S., Venditti, F. J., & Sidhu, M. S. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-021-07313-9 · Cited by 13
Fowler, B. A., Chou, C.-Y., Jones, R. L., Max Costa, & Chen, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822946-0.00037-4 · Cited by 13
Self-citationChakrabarty, N. (2015) · CRC Press eBooks · doi:10.1201/b18734 · Cited by 13
International research on arsenic contamination and health.
Rahman, M. (2006) · PubMed · Cited by 12
Qu, C., & Huang, R. (2022) · Nutrients · doi:10.3390/nu14193993 · Cited by 10
Yue, Y., Nair, N., Quiñones, S., Kordas, K., & Desai, G. S. (2022) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2022.113950 · Cited by 10
Jiang, M., Ma, X., Zheng, Y., Yang, Z., Guo, J., Huang, C. Z., & Liu, Q. (2023) · Environment & Health · doi:10.1021/envhealth.3c00110 · Cited by 9
Shi, H., Wang, J., Yuan, J., Tan, X., Wang, X., Chen, C., & Feng, S. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134752 · Cited by 9
Self-citationMondal, N. K., Roy, P., Das, B. K., & Datta, J. (2011) · International Journal on Environmental Sciences · Cited by 9
Chen and Chiou Respond to “Arsenic and Cancer of the Urinary Tract” by Cantor
Chen, C., & Chiou, H.-Y. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.5.422 · Cited by 9
Self-citationSahu, S., Sheet, T., & Banerjee, R. (2019) · RSC Advances · doi:10.1039/c8ra08225a · Cited by 9
Molecular Mechanisms in the Phytoremediation of Heavy Metals from Coastal Waters
Trivedi, S., & Ansari, A. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-10969-5_19 · Cited by 8
Neuro-inflammation Induced by Arsenic: An Insight into Mechanisms and Pathways Involved
Reddy, A. R. T., Mahadik, S. R., Choudhary, K., Pothuraju, N., Singh, S., Murti, K., Ramalingam, P., & Kumar, N. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04717-8 · Cited by 9
Arsenic and Oxidative Stress: An Overview
Zargari, F. (2021) · Springer eBooks · doi:10.1007/978-981-33-6068-6_2 · Cited by 7
Health effects of chronic arsenic toxicity
Mazumder, D. N. G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89847-8.00017-1 · Cited by 7
„If I have seen further, it is by standing on the shoulders of giants”
Matysiak, A. (2016) · Studia Demograficzne · Cited by 6
Arseniasis in the World: From Endemic to Pandemic
Chen, C. (2011) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814291828_0001 · Cited by 5
Self-citationCapitani, E. M. D. (2011) · Arsenic in the environment · doi:10.1201/b10772-4 · Cited by 5
Poręba, R., Skoczyńska, A., Gać, P., Turczyn, B., & Wojakowska, A. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.07.012 · Cited by 6
Wu, M., Chiou, H., Ho, I., Chen, C., & Lee, T. (2008) · Environmental Health Perspectives · doi:10.1289/txg.6396 · Cited by 5
Self-citationMoyad, M. A. (2002) · Urologic Clinics of North America · doi:10.1016/s0094-0143(02)00013-7 · Cited by 5
Human Health Effects of Chronic Arsenic Exposure
Hashim, A. (2023) · Environmental science and engineering · doi:10.1007/978-3-031-37561-3_3 · Cited by 4
Management of Chronic Arsenicosis
Jakariya, M., Chowdhury, R., Hossain, M., & Rahman, M. (2003) · Tropical Doctor · doi:10.1177/004947550303300426 · Cited by 4
ABCA1 Is Coordinated with ABCB1 in the Arsenic-Resistance of Human Cells
Zhou, T., Niu, W., Yuan, Z., Guo, S., Song, Y., Di, C., Xu, X., Tan, X., & Yang, L. (2018) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-2800-9 · Cited by 4
Jiang, S.-J., Lin, T., Shi, G.-Y., Eng, H.-L., Chen, H.-Y., & Wu, H. (2004) · Journal of Biomedical Science · doi:10.1007/bf02256099 · Cited by 4
Arsenic and the Cardiovascular System
Mehta, A. K., Ramachandra, C. J. A., & SHIM, W. S. N. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418688-0.00020-4 · Cited by 3
Shin, S. Y., & Min, B. G. (2022) · Fibers and Polymers · doi:10.1007/s12221-022-4808-6 · Cited by 3
SYSTEMIC HEALTH EFFECTS ASSOCIATED WITH SODIUM ARSENITE EXPOSURE: A REAPPRAISAL
ASHRAF, S., TAHIR, A., AMJAD, A., HAMEED, S., IMTIAZ, R., Shabbir, A., & Shehzadi, R. (2023) · Biological and Clinical Sciences Research Journal · doi:10.54112/bcsrj.v2023i1.601 · Cited by 2
Arsenic and It’s Adjuvantic Role on Oxidative Stress in Animals: A Brief Overview
Giri, A., Bharti, V. K., Angmo, K., Kalia, S., Vivek, P., & Kumar, B. (2016) · International Journal of Current Research in Biosciences and Plant Biology · doi:10.20546/ijcrbp.2016.312.013 · Cited by 3
Takebayashi, T. (2011) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.66.13 · Cited by 3
Dissertation zur Erlangung des Grades
der Naturwissenschaften, D., Osnabrück, U., Bröcker, C., & März, O. (2014) · Cited by 3
Evaluation of Hydroquinone, Mercury and Arsenic in Skin-Lightening Cosmetics Marketed in NigeriaPreprint
Bamidele, O. D., Kayode, B. A., Eniayewu, O., Adegbola, A. J., Olatoye, R. S., Njinga, N. S., Abdullahi, S. T., & Bakare-Odunola, M. T. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3984080 · Cited by 3
Fowles, J. R., Weinstein, P., & Tseng, C. (2012) · Springer eBooks · doi:10.1007/978-94-007-4375-5_24 · Cited by 2
Self-citationRamos, R. R., Ostrosky‐Wegman, P., & Cebrián, M. E. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-956-7_33 · Cited by 1
Wang, C. (2011) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814291828_0007 · Cited by 1
Toxicity of arsenicals in diseases: friend or foe?
Hossain, E., Wahiduzzaman, M., & Ota, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85215-9.00026-x · Cited by 1
Proposed Mechanisms of Arsenic Toxicity Carcinogenesis
Luster, M. I., & Simeonova, P. P. (2001) · CRC Press eBooks · doi:10.1201/9780203904787.ch5 · Cited by 1
Slayton, T. M., Lewis, A. S., & Beck, B. D. (2008) · Encyclopedia of Quantitative Risk Analysis and Assessment · doi:10.1002/9780470061596.risk0441 · Cited by 1
Arsenic-induced developmental changes in the liver and adult cardiovascular disease.
Ngalame, N. N. O. (2011) · doi:10.18297/etd/1055
Effect of Arsenic on Early Chick Development
Laghari, Z. A., Samo, A. A., Palh, Z. A., Lashari, K. H., & Mastoi, G. M. (2014) · International Journal of Sciences: Basic and Applied Research
Brima, E. I., Harrington, C. F., Jenkins, R. O., Gault, A. G., Polya, D. A., Pearson, G. F., Greenway, G. M., & Haris, P. I. (2013) · Biomedical Spectroscopy and Imaging · doi:10.3233/bsi-130046
Human Population Studies and Nutritional Intervention
Chen, Y., & Wu, F. (2015) · doi:10.1002/9781118876992.ch5
Update onarsenic Exposure Link inCancer
Mustafa, M., Muniandy, R., Ellzam, E., Iftikar, H., Fairrul, K., Nang, M., & Sharifa, A. (2017) · IOSR Journal of Dental and Medical Sciences · doi:10.9790/0853-16060196101
MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED XENOBIOTIC METABOLIZING ENZYMES BY ARSENITE
Anwar-Mohamed, A. G. A. E.-N. (2013) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3mq2f
Arsenic in HPV Related Oral Carcinoma- A New Threat of the Decade
Pal, M. P., & Halder, A. (2018) · International Journal Of Medical Science And Clinical Invention · doi:10.18535/ijmsci/v5i11.02
Jean, J.-S. (2010) · Arsenic in the environment · doi:10.1201/b10535-12
(2015) · doi:10.1201/b18734-1
Environmental Toxicants and Cardiovascular Behavioral Medicine
Gump, B. B. (2022) · Springer eBooks · doi:10.1007/978-0-387-85960-6_30
Arsenic and cardiovascular system
Mehta, A. K., & Ramachandra, C. J. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89847-8.00015-8
(2006) · CSIRO Publishing eBooks · doi:10.1071/9780643093515.part06
Arsenome, Arsenobolome, and Arsenobiolome
Pereira, F. J., López, R., & Aller, A. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110761
Chronic Arsenic Poisoning and Increased Risk of Stroke
Wang, C., & Chen, C. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9663-3_32
Self-citationSammulfar pharmacological uses and toxicological effect on systemic organs a revive studies
Raghubanshi, Sabir, B., Ahmad, T., & Sehar, N. (2026) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20261057
Metadata
- Authors
- Hsueh, Y.-M., Wu, W.-L., Huang, Y.-L., Chiou, H.-Y., Tseng, C.-H., & Chen, C.-J.
- Affiliations
- Taipei Medical University (TW)
- National Taiwan University Hospital (TW)
- National Taiwan University (TW)
- Corresponding author
- Chen, Chien-Jen
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 141
- Issue
- 2
- Pages
- 249-257
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1998589461
- Cited by
- 159
- References
- 53
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- arsenic exposure, ischemic heart disease, serum carotene, alpha-carotene, beta-carotene, antioxidant micronutrients, artesian well water, arseniasis, hypertension, body mass index, dose-response relationship, synergistic interaction, cardiovascular risk factors
- MeSH terms
- Lycopene, Adult, Alcohol Drinking, Antioxidants, Arsenic, Carotenoids, Chromatography, High Pressure Liquid, Humans, Surveys and Questionnaires, Risk Factors, Smoking, Socioeconomic Factors, Taiwan, Time Factors, Vitamin A, Vitamin E, Water Supply, Multivariate Analysis, Myocardial Ischemia, beta Carotene
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
