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Cited by 159Arsenic contamination and mitigationHeavy Metal Exposure and ToxicityAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure

Hsueh, Yu-Mei, Wu, Wen-Lin, Huang, Ya-Li, Chiou, Hung-Yi, Tseng, Chin-Hsiao, Chen, Chien-Jen·1998·Atherosclerosis
DOI 10.1016/s0021-9150(98)00178-6
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Abstract

To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex-matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose-response relationship with arsenic-related ISHD was observed for serum level of alpha- and beta-carotene, but not for serum levels of retinol, lycopene and alpha-tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic.

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Crossref · 10.1016/s0021-9150(98)00178-6

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Citations

Cites

Research works printed but not linked: 5

  1. Grobe, 1976, Peripheral circulatory disorders and acrocyanosis with arsenic, Berufs Dermatosen, 24, 78
  2. Wu, 1961, Epidemiologic studies on blackfoot disease: I. Prevalence and incidence of the disease by age, sex, occupation and geographical distribution, Mem College Med Natl Taiwan Univ, 7, 33
  3. Kuo TL. Arsenic content of artesian well water in endemic area of chronic arsenic poisoning. Reports, Institute of Pathology, National Taiwan University 1964; 20:7–13.
  4. Yeh, 1980, Trace element in water samples from the endemic area of blackfoot disease and biospecimens from blackfoot disease patients: a preliminary report, Blackfoot Dis Res Rep, 8, 22
  5. Stamler J, Ruth KJ, Liu K, Shekkele RB. Dietary antioxidants and blood pressure change in the western electric study (abstract). 34th Annual Conference on Cardiovascular Disease Epidemiology and Prevention. Tampa, Florida, 1993.

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Metadata

Authors
Hsueh, Y.-M., Wu, W.-L., Huang, Y.-L., Chiou, H.-Y., Tseng, C.-H., & Chen, C.-J.
Affiliations
  • Taipei Medical University (TW)
  • National Taiwan University Hospital (TW)
  • National Taiwan University (TW)
Corresponding author
Chen, Chien-Jen
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
1998-12
Volume
141
Issue
2
Pages
249-257
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/s0021-9150(98)00178-6
OpenAlex
W1998589461
Cited by
159
References
53
Citations by year
2026: 1 · 2025: 3 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 6 · 2012: 5
FWCI
2.83
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
arsenic exposure, ischemic heart disease, serum carotene, alpha-carotene, beta-carotene, antioxidant micronutrients, artesian well water, arseniasis, hypertension, body mass index, dose-response relationship, synergistic interaction, cardiovascular risk factors
MeSH terms
Lycopene, Adult, Alcohol Drinking, Antioxidants, Arsenic, Carotenoids, Chromatography, High Pressure Liquid, Humans, Surveys and Questionnaires, Risk Factors, Smoking, Socioeconomic Factors, Taiwan, Time Factors, Vitamin A, Vitamin E, Water Supply, Multivariate Analysis, Myocardial Ischemia, beta Carotene

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