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In humans, vascular endothelial function is relatively impaired in the morning, and therefore potentially implicated in the morning increase in adverse cardiovascular events.
“In humans, vascular endothelial function is relatively impaired in the morning (6, 123-126), and therefore potentially implicated in the morning increase in adverse CV events (127).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [126]
Cited by
Sorted by citations
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents
Urbina, E. M., Williams, R. V., Alpert, B. S., Collins, R. T., Daniels, S. R., Hayman, L. L., Jacobson, M., Mahoney, L. T., Mietus‐Snyder, M., Rocchini, A. P., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.192639 · Cited by 642 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Variability of flow mediated dilation: consequences for clinical application
Hijmering, M. L., Stroes, E. S. G., Pasterkamp, G., Sierevogel, M. J., Banga, J. D., & Rabelink, T. J. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00748-6 · Cited by 161 · see citing works
Gaenzer, H., Neumayr, G., Marschang, P., Sturm, W., Kirchmair, R., & Patsch, J. R. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01575-3 · Cited by 101 · see citing works
Self-citationPronounced postprandial lipemia impairs endothelium-dependent dilation of the brachial artery in men
Gaenzer, H. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00427-8 · Cited by 98 · see citing works
Self-citationJones, H., Green, D. J., George, K., & Atkinson, G. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00442.2009 · Cited by 85 · see citing works
Hermansen, K., Hansen, B., Jacobsen, R., Clausen, P., Dalgaard, M., Dinesen, B., Holst, J. J., Pedersen, E. B., & Astrup, A. V. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602151 · Cited by 78 · see citing works
Arterial structure and function during and after long-duration spaceflight
Lee, S. M. C., Ribeiro, L. C., Martin, D. S., Zwart, S. R., Feiveson, A. H., Laurie, S. S., Macias, B. R., Crucian, B. E., Krieger, S., Weber, D., et al. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00550.2019 · Cited by 72 · see citing works
Circadian Rhythm of Vascular Function in Midlife Adults
Thosar, S. S., Berman, A. M., Herzig, M. X., McHill, A. W., Bowles, N. P., Swanson, C. M., Clemons, N. A., Butler, M. P., Clemons, A. A., Emens, J. S., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312682 · Cited by 68 · see citing works
Brant, L. C. C., Barreto, S. M., Passos, V. M. D. A., & Ribeiro, A. L. P. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328362d913 · Cited by 64 · see citing works
“The second exam was carried out at least 2 h after the first to avoid a carryover effect and after a low calorie meal, both shown not to affect the response to hyperemia [16,32].”
Early and late effects of alcohol ingestion on blood pressure and endothelial function
Bau, P. F. D., Bau, C. H. D., Naujorks, A. A., et al. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.10.034 · Cited by 62 · see citing works
“This result is consistent with the results of Hashimoto et al. (2001), which verified a percent FMD decrease after the acute consumption of Japanese vodka.”
BackgroundResultInfluentialFahs, C. A., Yan, H., Ranadive, S. M., Rossow, L. M., Agiovlasitis, S., Wilund, K. R., & Fernhall, B. (2010) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h10-020 · Cited by 57 · see citing works
“Although previous studies using an HFM to induce endothelial dysfunction were performed in the morning after an overnight fast, we did not follow this approach because endothelial function may be impaired in the morning because of a higher vasoconstrictor tone upon waking (Gaenzer et al. 2000; Elherik et al. 2002).”
BackgroundResultVariation in non-invasive measurements of vascular function in healthy volunteers during daytime
ter Avest, E., Holewijn, S., Stalenhoef, A. F. H., & Graaf, J. D. (2005) · Clinical Science · doi:10.1042/cs20040300 · Cited by 54 · see citing works
Monnink, S. H. J., van Haelst, P. L., Boven, A. J. V., Stroes, E. S. G., Tio, R. A., Plokker, T. W. M., Smit, A. J., Veeger, N. J. G. M., Crijns, H. J. G. M., & van Gilst, W. H. (2002) · Journal of Investigative Medicine · doi:10.2310/6650.2002.33513 · Cited by 52 · see citing works
Circadian control of human cardiovascular function
Thosar, S. S., & Shea, S. A. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.01.002 · Cited by 48 · see citing works
“In humans, VEF is relatively impaired in the morning [17,58] compared to other times of the day.”
BackgroundHallmark, R. A., Patrie, J. T., Liu, Z., Gaesser, G. A., Barrett, E. J., & WELTMAN, A. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085450 · Cited by 44 · see citing works
“A diurnal variation in FMD has been reported in healthy adults [16,17], with FMD typically being lowest in early morning hours and then increasing throughout the morning and afternoon [16].”
BackgroundHirsch, L., Shechter, A., Feinberg, M. S., Koren‐Morag, N., & Shechter, M. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.08.069 · Cited by 37 · see citing works
Zhu, W., Zeng, J., Yin, J., Zhang, F., Wu, H., Yan, S., & Wang, S. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1283-3 · Cited by 36 · see citing works
“When a diurnal eVect on FMD has been shown (Gaenzer et al. 2000; Otto et al. 2004; Walters et al. 2006), this has been based on long interval (at least 4 h) between measurements.”
BackgroundMethodThe influence of alcohol consumed with a meal on endothelial function in healthy individuals
Hampton, S., Isherwood, C., Kirkpatrick, V. J. E., et al. (2010) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2009.01021.x · Cited by 29 · see citing works
“It is possible that the increase in endothelial function observed after 30 min could be prolonged had the experiment been conducted later in the day when FMD is reported to be increased (Gaenzer et al., 2000; Walters et al., 2006).”
BackgroundDiurnal Variation in Vascular Function: Role of Sleep
Jones, H., Lewis, N. C. S., Thompson, A., Marrin, K., GREEN, D. J., & Atkinson, G. (2012) · Chronobiology International · doi:10.3109/07420528.2012.654554 · Cited by 27 · see citing works
“Previous studies have utilized research designs that involve measurements at different times of day, where the morning test is preceded by nocturnal sleep (Bau et al., 2008; Etsuda et al., 1999; Gaenzer et al., 2000; Jones et al., 2010, 2011; Kawano et al., 2002; Kollias et al., 2009; Otto et al., 2004).”
BackgroundResultInfluentialDiurnal variation of vascular diameter and reactivity in healthy young men
Bau, P. F. D., Bau, C. H. D., Naujorks, A. A., Rosito, G. A., & Fuchs, F. D. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008005000012 · Cited by 25 · see citing works
“br individuals with (9,10) or without (11) a higher risk of developing cardiovascular events.”
BackgroundDalli, E., Segarra, L., Ruvira, J., et al. (2002) · Revista Española de Cardiología · doi:10.1016/s0300-8932(02)76731-6 · Cited by 24 · see citing works
Circadian variation in endothelial function is attenuated in postmenopausal women
Walters, J. F., Hampton, S. M., Deanfield, J. E., Donald, A. E., Skene, D. J., & Ferns, G. A. (2006) · Maturitas · doi:10.1016/j.maturitas.2005.12.005 · Cited by 24 · see citing works
Tucker, W. J., Sawyer, B. J., Jarrett, C. L., Bhammar, D. M., Ryder, J. R., Angadi, S. S., & Gaesser, G. A. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00384.2017 · Cited by 19 · see citing works
Jones, H., Lewis, N. C. S., GREEN, D. J., et al. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00042.2011 · Cited by 17 · see citing works
Thosar, S. S., Berman, A. M., Herzig, M. X., Roberts, S. A., Lasarev, M. R., & Shea, S. A. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00143.2018 · Cited by 14 · see citing works
New insights into the mechanisms of temporal variation in the incidence of acute coronary syndromes
Strike, P. C., & Steptoe, A. (2003) · Clinical Cardiology · doi:10.1002/clc.4960261103 · Cited by 13 · see citing works
Bunsawat, K., Ratchford, S. M., Alpenglow, J. K., Park, S. H., Jarrett, C. L., Stehlik, J., Drakos, S. G., Richardson, R. S., & Wray, D. W. (2020) · Experimental Physiology · doi:10.1113/ep088686 · Cited by 10 · see citing works
Ballard, K. D., Timsina, R., & Timmerman, K. L. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1907395 · Cited by 11 · see citing works
“…artery FMD (Cotie et al. 2016), suggesting that elevated circulating ET-1 levels may contribute to the impairment of VEF (Etsuda et al. 1999; Gaenzer et al. 2000; Jones et al. 2010, 2011; Kawano et al. 2002; Kollias et al. 2009; Otto et al. 2004; Thosar et al. 2019) and heightened CVD risk…”
BackgroundResultInfluentialMaruyama, M., Hara, T., Hashimoto, M., Koga, M., & Shido, O. (2006) · International Journal of Biometeorology · doi:10.1007/s00484-005-0023-6 · Cited by 8 · see citing works
Effect of time of day and rabbit strain on patterns of aortic wall permeability
Staughton, T. J., & Weinberg, P. D. (2003) · Experimental Physiology · doi:10.1113/expphysiol.2003.002635 · Cited by 7 · see citing works
“studies of flow-mediated dilatation of the human brachial artery, an NO-dependent phenomenon, unequivocally demonstrate a circadian rhythm, the response to flow being approximately twice as great at 16:00 or 17:00 h as at 08:00 h (Etsuda et al. 1999; Gaenzer et al. 2000).”
BackgroundIncreased myocardial ischemia after food is not explained by endothelial dysfunction
Edwards, C. C., Stewart, R., Ramanathan, K., et al. (2002) · American Heart Journal · doi:10.1067/mhj.2002.125624 · Cited by 6 · see citing works
Exercise-induced arterial adaptations in elite judo athletes.
Karagounis, P., Maridaki, M. D., Papaharalampous, X., Prionas, G., & Baltopoulos, P. (2009) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Flußvermittelte Vasodilatation (FMD) der Arteria brachialis: Methodik und klinischer Stellenwert
Frick, M., Neunteufl, T., Sp, S., et al. (2002) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 5 · see citing works
A cross-sectional evaluation of seasonality as a determinant of endothelial function
Patel, Y. R., Han, K., Lteif, A. A., et al. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.05.010 · Cited by 4 · see citing works
Resting and recruitable endothelial function – Evidence of two distinct circadian patterns
Vosseler, M., Shazly, A. E., Parker, J. D., Münzel, T. F., & Gori, T. (2019) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-190587 · Cited by 3 · see citing works
“Conduit artery endothelial function follows a circadian rhythm, with an attenuation of FMD in the morning to levels that, in healthy subjects, are very similar to those recorded in patients with cardiovascular disease [5, 8, 9, 21, 22].”
Wine Dilates the Brachial Artery but does not Increase Flow-mediated Dilatation over Two Hours
Blackhurst, D., Wolmarans, K. H., & Marais, A. (2016) · South African Journal of Enology and Viticulture · doi:10.21548/28-1-1454 · Cited by 2 · see citing works
“In 1986, Ludmer et al. (1986) reported that endothelial dysfunction was associated with atherosclerosis, and this has subsequently been confirmed (Gordon et al., 1989; Healy, 1990).”
BackgroundTarget Organ Damage Related to Cardiovascular Risk Factors in Youth
Urbina, E. M. (2011) · Springer eBooks · doi:10.1007/978-94-007-1451-9_9 · Cited by 1 · see citing works
Arterial structure and function in the years after long-duration spaceflight
Lee, S. M. C., Ribeiro, L. C., Martin, D. S., Laurie, S. S., Zwart, S. R., Chen, X., Young, M., Crucian, B. E., Smith, S. M., & Macias, B. R. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00264.2024 · Cited by 2 · see citing works
Nondipping status and impaired nitroglycerin-mediated vasodilation in resistant hypertension
Palatini, P., & Grassi, G. M. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000641 · Cited by 1 · see citing works
Marlatt, K. L. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
ЦИРКАДНЫЕ ГЕНЫ И СЕРДЕЧНОСОСУДИСТЫЕ ПАТОЛОГИИ И. В. Курбатова, Л. В. Топчиева, Н. Н. Немова
Валерьевна, К. И., Topchieva, L. V., & Немова, Н. Н. (2014) · CyberLeninK (CyberLeninka)
The assessment of endothelial function in pregnancy by flow-mediated dilatation.
Quinton, A. E. (2011) · The Sydney eScholarship Repository (The University of Sydney)
- Authors
- Gaenzer, H., Sturm, W., Kirchmair, R., Neumayr, G., Ritsch, A., & Patsch, J. R.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 149
- Issue
- 1
- Pages
- 227-228
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2396262873
- Cited by
- 44
- References
- 0
- Citations by year
- 2025: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- MeSH terms
- Adult, Blood Flow Velocity, Brachial Artery, Circadian Rhythm, Endothelium, Vascular, Nitroglycerin, Humans, Male, Reference Values, Vasodilation, Vasodilator Agents, Ultrasonography, Interventional
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