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Cited by 676

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals.

Open access
Chance, B., Schoener, B., Oshino, R., Itshak, F., Nakase, Y.·1979·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)30079-0
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Abstract

The recording of oxidation-reduction-related fluorescence signals of oxidized flavoprotein (Fp) and reduced pyridine nucleotide (PN) from isolated mitochondria at temperatures below -80 degrees C can be accompanished with a high degree of accuracy and a wide dynamic range. The specific low temperature enhancement of the fluorescence signals due to increased quantum yield and to multiple scattering affords increased accuracy and less interference due to screening pigments such as hemoglobin and myoglobin. Since the metabolic processes are arrested and the recording speed can be greatly diminished, the technique can operate with a much smaller concentration of mitochondria than is needed at room temperature, and the method is suitable for localized oxidation-reduction measurements. The Fp and PN signals originate from the mitochondrial matrix space in which they represent the major fluorochromes. Since Fp and PN are near oxidation-reduction equilibrium, the ratio of the two fluorescence intensities, suitably normalized, approximates the oxidation-reduction ratio of oxidized flavoprotein/reduced pyridine nucleotide. Thus, this technique affords a foundation for the resolution of oxidation-reduction states in two and three dimensions.

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Metadata

Authors
Chance, B., Schoener, B., Oshino, R., Itshak, F., & Nakase, Y.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1979-06
Volume
254
Issue
11
Pages
4764-4771
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(17)30079-0
OpenAlex
W1892152977
Cited by
676
References
17
FWCI
1.19
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals. https://app.cochat.ai/papers/10.1016/s0021-9258(17)30079-0
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Chance, B., Schoener, B., Oshino, R., Itshak, F., & Nakase, Y. (1979). Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)30079-0

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.