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Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.
Open accessAbstract
A new metabolite of arachidonic acid, 5-D-(S),12-D-(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid, was found upon incubation of the fatty acid with a suspension of rabbit peritoneal polymorphonuclear leukocytes collected 4 h after injection of glycogen into the peritoneal cavity. The yield of the dihydroxy acid was 0.5 to 2%. The compound possesses three conjugated double bonds and was found to be stereochemically pure at C-5 and C-12. Incubation of the cells with 8,11,14-eicosatrienoic acid did not lead to the formation of the analogous triunsaturated dihydroxy acid.
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Citations
Cited by
Lewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
Murphy, R. C., Hammarström, S., & Samuelsson, B. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4275 · Cited by 991
Self-citationLipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875
Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease
Sharon, P., & Stenson, W. F. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80015-3 · Cited by 738
Wolfe, L. S. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb10847.x · Cited by 573
Metadata
- Authors
- Borgeat, P., & Samuelsson, B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-04
- Volume
- 254
- Issue
- 8
- Pages
- 2643-2646
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1631595783
- Cited by
- 648
- References
- 0
- FWCI
- 21.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid. https://app.cochat.ai/papers/10.1016/s0021-9258(17)30120-5
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- Borgeat, P., & Samuelsson, B. (1979). Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)30120-5
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