The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
Open accessAbstract
Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig ileum to contract. The response was reversed by the SRS antagonist FPL 55712. On the basis of isotope incorporation experiments, spectroscopy, and chemical degradations, the SRS was identified as a cysteine-containing derivative of 5-hydroxy-7,9,11,14-icosatetraenoic acid. This amino acid was attached in thioether linkage at C-6. The SRS is structurally related to previously identified epoxy and dihydroxy metabolites of arachidonic acid in leukocytes. A common feature is the presence of a conjugated triene, and the name "leukotriene" has been introduced to designate these compounds. Leukotriene A (5,6-epoxy-7,9,11,14-icosatetraenoic acid) is an intermediate in the formation of leukotriene B (5,12-dihydroxy-6,8,10,14-icosatetraenoic acid) and is proposed to be a precursor also of leukotriene C, which is the SRS identified here.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Arachidonic acid metabolism in polymorphonuclear leukocytes: Effects of ionophore A23187
Borgeat, P., & Samuelsson, B. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.5.2148 · Cited by 803
Self-citationOn the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase
Hamberg, M., & Samuelsson, B. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99432-9 · Cited by 656
Self-citationBorgeat, P., & Samuelsson, B. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30120-5 · Cited by 648
Self-citationBorgeat, P., & Samuelsson, B. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3213 · Cited by 470
Self-citationLiberation of histamine and formation of lysocithin‐like substances by cobra venom
Feldberg, W., & Kellaway, C. H. (1938) · The Journal of Physiology · doi:10.1113/jphysiol.1938.sp003674 · Cited by 377
Slow Reacting Substance of Anaphylaxis
Orange, R. P., & Austen, K. F. (1969) · Advances in immunology · doi:10.1016/s0065-2776(08)60416-2 · Cited by 229
ENGINEER, D. M., NIEDERHAUSER, U., PIPER, P. J., & SIROIS, P. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07006.x · Cited by 188
The Physicochemical Characteristics and Purification of Slow-Reacting Substance of Anaphylaxis
Orange, R. P., Murphy, R. C., Karnovsky, M. L., & Austen, K. F. (1973) · The Journal of Immunology · doi:10.4049/jimmunol.110.3.760 · Cited by 185
Self-citationHomeostasis of effector systems which can also be recruited for immunologic reactions.
Austen, K. F. (1978) · PubMed · Cited by 113
Bach, M. K., Brashler, J. R., & Gorman, R. R. (1977) · Prostaglandins · doi:10.1016/0090-6980(77)90154-x · Cited by 113
Cited by
Lewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200
Dahlén, S. E., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3887 · Cited by 1,019
Self-citationLipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875
Leier, I., Jedlitschky, G., Buchholz, U., Cole, S. P., Deeley, R. G., & Keppler, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46856-1 · Cited by 853
Wolfe, L. S. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb10847.x · Cited by 573
Metadata
- Authors
- Murphy, R. C., Hammarström, S., & Samuelsson, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-09
- Volume
- 76
- Issue
- 9
- Pages
- 4275-4279
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2123773797
- Cited by
- 991
- References
- 11
- FWCI
- 35.98
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Leukotriene C: a slow-reacting substance from murine mastocytoma cells. https://app.cochat.ai/papers/10.1073/pnas.76.9.4275
- The paper
- Murphy, R. C., Hammarström, S., & Samuelsson, B. (1979). Leukotriene C: a slow-reacting substance from murine mastocytoma cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.9.4275
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
