The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Opioid peptides derived from food proteins. The exorphins
Open accessAbstract
Peptides with opioid activity are found in pepsin hydrolysates of wheat gluten and alpha-casein. The opioid activity of these peptides was demonstrated by use of the following bioassays: 1) naloxone-reversible inhibition of adenylate cyclase in homogenates of neuroblastoma X-glioma hybrid cells; 2) naloxone-reversible inhibition of electrically stimulated contractions of the mouse vas deferens; 3) displacement of [3H]dihydromorphine and [3H-Tyr, dAla2]met-enkephalin amide from rat brain membranes. Substances which stimulate adenylate cyclase and increase the contractions of the mouse vas deferens but do not bind to opiate receptors are also isolated from gluten hydrolysates. It is suggested that peptides derived from some food proteins may be of physiological importance.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Food-derived peptides with biological activity: from research to food applications.
Hartmann, R., & Meisel, H. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.01.013 · Cited by 1,102
Bioactive milk peptides: a prospectus.
Clare, D. A., & Swaisgood, H. E. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74983-6 · Cited by 718
Opioid activities and structures of alpha-casein-derived exorphins.
Loukas, S., Varoucha, D., Zioudrou, C., Streaty, R. A., & Klee, W. A. (1983) · Biochemistry · doi:10.1021/bi00288a034 · Cited by 167
Self-citationFiat, A.-M., & Joll�s, P. (1989) · Molecular and Cellular Biochemistry · doi:10.1007/bf00421079 · Cited by 163
Opioid peptides derived from wheat gluten: their isolation and characterization.
Fukudome, S.-I., & Yoshikawa, M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80414-c · Cited by 142
Metadata
- Authors
- Zioudrou, C., Streaty, R. A., & Klee, W. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-04
- Volume
- 254
- Issue
- 7
- Pages
- 2446-2449
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1506571128
- Cited by
- 374
- References
- 1
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zioudrou, C., Streaty, R. A., & Klee, W. A. (1979). Opioid peptides derived from food proteins. The exorphins. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)30243-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
