The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Open accessAbstract
We describe experiments which show that: 1) two previously identified members of the GATA family of transcription factors (both of which were originally called GATA-4) correspond to chicken cDNAs for two distinct factors (which we now refer to as cGATA-4 and cGATA-5); 2) another new member of this family corresponds to a third factor designated cGATA-6; 3) each of these mRNAs displays a differential expression pattern. The cGATA-5 gene is initially transcribed in the cardiac crescent prior to formation of the primordial heart tube. Following formation of the primitive heart, cGATA-5 transcripts are evident in both endocardium and myocardium as well as in other lateral plate derivatives. The cGATA-5 gene is also transcribed in the primitive embryonic gut and in late stage embryos is sequentially up-regulated in distinct segments of gastrointestinal epithelia as they undergo terminal differentiation. These studies thus provide novel insights into tissue-specific regulation by GATA-5, as well as into possibly overlapping regulatory functions for these three family members.
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“Indeed, we observed a large overlap between known pioneer TFs and proteins that bind to methylated DNA (for example, forkhead box protein A (FOXA) and GATA families, which are the best-studied pioneer factors)106,108–110.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [109]
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Pioneer transcription factors: establishing competence for gene expression
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Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.Preprint
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GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.Preprint
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Metadata
- Authors
- Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T.
- Affiliations
- Fox Chase Cancer Center (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 269
- Issue
- 37
- Pages
- 23177-23184
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1577509897
- Cited by
- 558
- References
- 42
- Citations by year
- 2025: 2 · 2024: 10 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 8 · 2013: 12 · 2012: 11
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k11ca001689-02)
- U.S. Public Health Service (35535)
- National Cancer Institute (CA-01689, P30CA006927, CA06927)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- GATA4, GATA5, GATA6, GATA transcription factors, heart development, intestinal development, endocardium, myocardium, lateral plate mesoderm, gastrointestinal epithelium, gene expression regulation, chick embryo, cDNA cloning
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Chick Embryo, Chickens, Digestive System, DNA-Binding Proteins, Epithelial Cells, Epithelium, Heart, Mesoderm, Molecular Sequence Data, Myocardium, Transcription Factors, Transcription, Genetic, Sequence Homology, Amino Acid, DNA, Complementary, GATA4 Transcription Factor, GATA5 Transcription Factor, GATA6 Transcription Factor
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