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Cited by 90DNA and Nucleic Acid ChemistryDNA Repair MechanismsRNA and protein synthesis mechanisms

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase

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Battula, N, Loeb, L A·1976·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)33789-4
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Abstract

Homogeneous DNA polymerase ("reverse transcriptase") from avian myeoblastosis virus was assayed for exodeoxyribonuclease activity. The substrates were defined template-initiator complexes in which different radioactive nucleotides were present at the 3'-OH termini of the initiator. Even when the number of molecules of enzyme was equal to the number of initiator termini there was no significant release of radioactivity with any of the template-initiator combinations tested. Under similar conditions, the nuclease activity associated with either Escherichia coli or T4DNA polymerases rendered more than 90% of the initiator termini acid-soluble. The ratio of exodeoxyribonuclease activity to protein with avian myeoblastosis DNA polymerase is less than 0.003% of that obtained with E. coli DNA polymerase I. Furthermore, avian myeloblastosis virus DNA polymerase failed to excise mispaired terminal nucleotides in both the presence and absence of polymerization.

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Crossref · 10.1016/s0021-9258(17)33789-4

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1 of 1 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • HIV-1 is more error-prone than HTLV and BLV because it replicates actively.

    “making them error-prone, especially for actively replicating retroviruses such as HIV-1 compared to others, such as HTLV and BLV”

    From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Battula and Loeb 1976

  • Retroviral RTs lack proofreading mechanisms such as 3′ exonuclease activity, making them error-prone.

    “The low fidelity of RT is primarily because retroviral RTs lack proofreading mechanisms (such as 3′ exonuclease activity), making them error-prone, especially for actively replicating retroviruses such as HIV-1 compared to others, such as HTLV and BLV (Battula and Loeb 1976, Starcich et al. 1986, Preston et al. 1988, Ratner et al. 1991, Dube et al. 1993, Willems et al. 1993).”

    From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Battula and Loeb 1976

Citations

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Research works printed but not linked: 24

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Metadata

Authors
Battula, N., & Loeb, L. A.
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1976-02
Volume
251
Issue
4
Pages
982-986
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(17)33789-4
OpenAlex
W1554784125
Cited by
90
References
1
Citations by year
2025: 1 · 2022: 1 · 2018: 1 · 2012: 1
FWCI
3.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
avian myeloblastosis virus, reverse transcriptase, DNA polymerase, error correction, Escherichia coli DNA polymerase I, T4 DNA polymerase
MeSH terms
Avian Leukosis Virus, Base Sequence, Coliphages, Deoxyribonucleases, DNA Nucleotidyltransferases, DNA Replication, Escherichia coli, Exonucleases, Molecular Weight, Avian Myeloblastosis Virus, Pancreas, RNA-Directed DNA Polymerase, Species Specificity, Templates, Genetic

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